scholarly journals Production of Composite Scaffold Containing Silk Fibroin, Chitosan, and Gelatin for 3D Cell Culture and Bone Tissue Regeneration

2017 ◽  
Vol 23 ◽  
pp. 5311-5320 ◽  
Author(s):  
Jianqing Li ◽  
Qiuke Wang ◽  
Yebo Gu ◽  
Yu Zhu ◽  
Liang Chen ◽  
...  
Keyword(s):  
Cell Culture ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Tissue Regeneration ◽  
Composite Scaffold ◽  
3D Cell Culture ◽  
Bone Tissue Regeneration

Biocompatibility of plasma-treated poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanofiber mats modified by silk fibroin for bone tissue regeneration

2016 ◽  
Vol 68 ◽  
pp. 842-850 ◽  
Author(s):  
Irem Unalan ◽  
Oylum Colpankan ◽  
Aylin Ziylan Albayrak ◽  
Cansu Gorgun ◽  
Aylin Sendemir Urkmez
Keyword(s):  
Bone Tissue ◽  
Silk Fibroin ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Nanofiber Mats

Fabrication andin vivoevaluation of an osteoblast-conditioned nano-hydroxyapatite/gelatin composite scaffold for bone tissue regeneration

2016 ◽  
Vol 104 (8) ◽  
pp. 2001-2010 ◽  
Author(s):  
Ali Samadikuchaksaraei ◽  
Mazaher Gholipourmalekabadi ◽  
Elham Erfani Ezadyar ◽  
Mahmoud Azami ◽  
Masoud Mozafari ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Composite Scaffold ◽  
Bone Tissue Regeneration

scholarly journals Current Stage of Marine Ceramic Grafts for 3D Bone Tissue Regeneration

Marine Drugs ◽  
2019 ◽  
Vol 17 (8) ◽  
pp. 471 ◽  
Author(s):  
Patricia Diaz-Rodriguez ◽  
Miriam López-Álvarez ◽  
Julia Serra ◽  
Pío González ◽  
Mariana Landín
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Alveolar Bone ◽  
3D Cell Culture ◽  
Spinal Fractures ◽  
Bone Grafts ◽  
Bone Tissue Regeneration ◽  
Marine Origin ◽  
Age Related ◽  
Current Stage

Bioceramic scaffolds are crucial in tissue engineering for bone regeneration. They usually provide hierarchical porosity, bioactivity, and mechanical support supplying osteoconductive properties and allowing for 3D cell culture. In the case of age-related diseases such as osteoarthritis and osteoporosis, or other bone alterations as alveolar bone resorption or spinal fractures, functional tissue recovery usually requires the use of grafts. These bone grafts or bone void fillers are usually based on porous calcium phosphate grains which, once disposed into the bone defect, act as scaffolds by incorporating, to their own porosity, the intergranular one. Despite their routine use in traumatology and dental applications, specific graft requirements such as osteoinductivity or balanced dissolution rate are still not completely fulfilled. Marine origin bioceramics research opens the possibility to find new sources of bone grafts given the wide diversity of marine materials still largely unexplored. The interest in this field has also been urged by the limitations of synthetic or mammalian-derived grafts already in use and broadly investigated. The present review covers the current stage of major marine origin bioceramic grafts for bone tissue regeneration and their promising properties. Both products already available on the market and those in preclinical phases are included. To understand their clear contribution to the field, the main clinical requirements and the current available biological-derived ceramic grafts with their advantages and limitations have been collected.

scholarly journals Biomimetic and osteogenic 3D silk fibroin composite scaffolds with nano MgO and mineralized hydroxyapatite for bone regeneration

2020 ◽  
Vol 11 ◽  
pp. 204173142096779
Author(s):  
Ziquan Wu ◽  
Zhulong Meng ◽  
Qianjin Wu ◽  
Delu Zeng ◽  
Zhengdong Guo ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Bone Repair ◽  
Composite Scaffold ◽  
Bone Tissue Regeneration ◽  
Bone Mesenchymal Stem Cells ◽  
Differentiation Potential ◽  
Composite Effect ◽  
Sd Rat

Artificial bioactive materials have received increasing attention worldwide in clinical orthopedics to repair bone defects that are caused by trauma, infections or tumors, especially dedicated to the multifunctional composite effect of materials. In this study, a weakly alkaline, biomimetic and osteogenic, three-dimensional composite scaffold (3DS) with hydroxyapatite (HAp) and nano magnesium oxide (MgO) embedded in fiber (F) of silkworm cocoon and silk fibroin (SF) is evaluated comprehensively for its bone repair potential in vivo and in vitro experiments, particularly focusing on the combined effect between HAp and MgO. Magnesium ions (Mg2+) has long been proven to promote bone tissue regeneration, and HAp is provided with osteoconductive properties. Interestingly, the weak alkaline microenvironment from MgO may also be crucial to promote Sprague-Dawley (SD) rat bone mesenchymal stem cells (BMSCs) proliferation, osteogenic differentiation and alkaline phosphatase (ALP) activities. This SF/F/HAp/nano MgO (SFFHM) 3DS with superior biocompatibility and biodegradability has better mechanical properties, BMSCs proliferation ability, osteogenic activity and differentiation potential compared with the scaffolds adding HAp or MgO alone or neither. Similarly, corresponding meaningful results are also demonstrated in a model of distal lateral femoral defect in SD rat. Therefore, we provide a promising 3D composite scaffold for promoting bone regeneration applications in bone tissue engineering.

Silk fibroin membrane used for guided bone tissue regeneration

2017 ◽  
Vol 70 ◽  
pp. 148-154 ◽  
Author(s):  
Yurong Cai ◽  
Junmao Guo ◽  
Cen Chen ◽  
Chenxue Yao ◽  
Sung-Min Chung ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Silk Fibroin ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration

Preparation of an rhBMP-2 loaded mesoporous bioactive glass/calcium phosphate cement porous composite scaffold for rapid bone tissue regeneration

2015 ◽  
Vol 3 (43) ◽  
pp. 8558-8566 ◽  
Author(s):  
Nan Li ◽  
Chuan Jiang ◽  
Xingdi Zhang ◽  
Xinfeng Gu ◽  
Jingwei Zhang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bioactive Glass ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Calcium Phosphate Cement ◽  
Composite Scaffold ◽  
Early Stage ◽  
Bone Tissue Regeneration ◽  
Porous Composite ◽  
Mesoporous Bioactive Glass

An rhBMP-2/MBG/CPC scaffold is beneficial for rapid bone tissue regeneration in the early stage.

Relevance of fiber integrated gelatin-nanohydroxyapatite composite scaffold for bone tissue regeneration

2015 ◽  
Vol 26 (40) ◽  
pp. 405101 ◽  
Author(s):  
Bibi Halima Shamaz ◽  
A Anitha ◽  
Manju Vijayamohan ◽  
Shruthy Kuttappan ◽  
Shantikumar Nair ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Composite Scaffold ◽  
Bone Tissue Regeneration

Novel calcified gum Arabic porous nano-composite scaffold for bone tissue regeneration

2017 ◽  
Vol 488 (4) ◽  
pp. 671-678 ◽  
Author(s):  
M. Hadavi ◽  
S. Hasannia ◽  
Sh. Faghihi ◽  
F. Mashayekhi ◽  
H.H. Zadeh ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Composite Scaffold ◽  
Gum Arabic ◽  
Bone Tissue Regeneration ◽  
Nano Composite
Sign in / Sign up

Export Citation Format

Share Document