scholarly journals Long Non-Coding RNA (LncRNA) HOXA11-AS Promotes Breast Cancer Invasion and Metastasis by Regulating Epithelial-Mesenchymal Transition

2017 ◽  
Vol 23 ◽  
pp. 3393-3403 ◽  
Author(s):  
Wenlei Li ◽  
Guotao Jia ◽  
Yanwen Qu ◽  
Qian Du ◽  
Baoguo Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Cancer Invasion ◽  
Invasion And Metastasis ◽  
Mesenchymal Transition ◽  
Breast Cancer Invasion ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals MicroRNAs regulate the epithelial–mesenchymal transition and influence breast cancer invasion and metastasis

Tumor Biology ◽  
2017 ◽  
Vol 39 (2) ◽  
pp. 101042831769168 ◽  
Author(s):  
Min Zhao ◽  
Lin Ang ◽  
Jin Huang ◽  
Jin Wang
Keyword(s):  
Breast Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Cancer Invasion ◽  
Invasion And Metastasis ◽  
Mesenchymal Phenotype ◽  
Mesenchymal Transition ◽  
Rna Molecules ◽  
Breast Cancer Invasion ◽  
Proliferation And Apoptosis ◽  
Post Transcriptional Regulation

MicroRNAs are small RNA molecules that play a major role in the post-transcriptional regulation of genes and influence the development, differentiation, proliferation, and apoptosis of cells and the development and progression of tumors. The epithelial–mesenchymal transition is a process by which epithelial cells morphologically transform into cells with a mesenchymal phenotype. The epithelial–mesenchymal transition plays a highly important role in tumor invasion and metastasis. Increasing evidence indicates that microRNAs are tightly associated with epithelial–mesenchymal transition regulation in tumor cells. In breast cancer, various microRNA molecules have been identified as epithelial–mesenchymal transition inducers or inhibitors, which, through different mechanisms and signaling pathways, participate in the regulation of breast cancer invasion and metastasis among various biological behaviors. The epithelial–mesenchymal transition–related microRNAs in breast cancer provide valuable molecules for researching cell invasion and metastasis, and they also provide candidate targets that may be significant for the targeted therapy of breast cancer.

Down-regulation of MALAT1 inhibits cervical cancer cell invasion and metastasis by inhibition of epithelial–mesenchymal transition

2016 ◽  
Vol 12 (3) ◽  
pp. 952-962 ◽  
Author(s):  
Ruili Sun ◽  
Changfei Qin ◽  
Binyuan Jiang ◽  
Shujuan Fang ◽  
Xi Pan ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factor ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Epithelial Mesenchymal Transition ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
Mesenchymal Transition ◽  
Non Coding Rna ◽  
Long Non Coding Rna

MALAT1, a member of the long non-coding RNA (lncRNA) family, has been reported to be highly enriched in many kinds of cancers and to be a metastasis marker and a prognostic factor.

scholarly journals Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yingjie Liu ◽  
Peiyuan Zhang ◽  
Qiuyao Wu ◽  
Houqin Fang ◽  
Yuan Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rna Binding ◽  
Epithelial Mesenchymal Transition ◽  
Disseminated Tumor Cells ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
Mesenchymal Transition ◽  
Non Coding Rna ◽  
Tumor Dissemination ◽  
Long Non Coding Rna

AbstractDisseminated tumor cells often fall into a long term of dormant stage, characterized by decreased proliferation but sustained survival, in distant organs before awakening for metastatic growth. However, the regulatory mechanism of metastatic dormancy and awakening is largely unknown. Here, we show that the epithelial-like and mesenchymal-like subpopulations of breast cancer stem-like cells (BCSCs) demonstrate different levels of dormancy and tumorigenicity in lungs. The long non-coding RNA (lncRNA) NR2F1-AS1 (NAS1) is up-regulated in the dormant mesenchymal-like BCSCs, and functionally promotes tumor dissemination but reduces proliferation in lungs. Mechanistically, NAS1 binds to NR2F1 mRNA and recruits the RNA-binding protein PTBP1 to promote internal ribosome entry site (IRES)-mediated NR2F1 translation, thus leading to suppression of ΔNp63 transcription by NR2F1. Furthermore, ΔNp63 downregulation results in epithelial-mesenchymal transition, reduced tumorigenicity and enhanced dormancy of cancer cells in lungs. Overall, the study links BCSC plasticity with metastatic dormancy, and reveals the lncRNA as an important regulator of both processes.

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