scholarly journals α-Linolenic Acid Inhibits Receptor Activator of NF-κB Ligand Induced (RANKL-Induced) Osteoclastogenesis and Prevents Inflammatory Bone Loss via Downregulation of Nuclear Factor-KappaB-Inducible Nitric Oxide Synthases (NF-κB-iNOS) Signaling Pathways

2017 ◽  
Vol 23 ◽  
pp. 5056-5069 ◽  
Author(s):  
Jiefu Song ◽  
Zhizhen Jing ◽  
Wei Hu ◽  
Jianping Yu ◽  
Xiaoping Cui
Keyword(s):  
Nitric Oxide ◽  
Bone Loss ◽  
Signaling Pathways ◽  
Linolenic Acid ◽  
Nitric Oxide Synthases ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor ◽  
Receptor Activator ◽  
Inducible Nitric Oxide

scholarly journals Synthesis and Anti-Inflammatory Activities of Phloroglucinol-Based Derivatives

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3232 ◽  
Author(s):  
Ning Li ◽  
Shabana Khan ◽  
Shi Qiu ◽  
Xing-Cong Li
Keyword(s):  
Nitric Oxide ◽  
Drug Discovery ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor ◽  
Future Drug ◽  
Ic50 Values ◽  
Inhibitory Activities ◽  
Anti Inflammatory ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

The natural product phloroglucinol-based derivatives representing monoacyl-, diacyl-, dimeric acyl-, alkylated monoacyl-, and the nitrogen-containing alkylated monoacylphloro- glucinols were synthesized and evaluated for inhibitory activities against the inflammatory mediators such as inducible nitric oxide synthase (iNOS) and nuclear factor kappaB (NF-κB). The diacylphloroglucinol compound 2 and the alkylated acylphloroglucinol compound 4 inhibited iNOS with IC50 values of 19.0 and 19.5 µM, respectively, and NF-κB with IC50 values of 34.0 and 37.5 µM, respectively. These compounds may serve as leads for the synthesis of more potent anti-inflammatory compounds for future drug discovery.

Acanthopanax senticosus aqueous extract ameliorates ovariectomy-induced bone loss in middle-aged mice by inhibiting the receptor activator of nuclear factor-κB ligand-induced osteoclastogenesis

2020 ◽  
Vol 11 (11) ◽  
pp. 9696-9709
Author(s):  
Huanhuan Xu ◽  
Jing Xu ◽  
Fei Chen ◽  
Titi Liu ◽  
Jin Li ◽  
...  
Keyword(s):  
Bone Loss ◽  
Signaling Pathways ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Middle Aged ◽  
Acanthopanax Senticosus ◽  
Treatment Of Osteoporosis ◽  
Aged Mice ◽  
Receptor Activator ◽  
Rank Signaling

ASAE ameliorates ovariectomy-induced bone loss in middle-aged mice by inhibiting RANKL-induced osteoclastogenesis through suppression of RANK signaling pathways and could be potentially used in mediated treatment of osteoporosis.

The Signaling Pathways in Nitric Oxide Production by Neutrophils Exposed to N-nitrosodimethylamine

2018 ◽  
Vol 16 (2) ◽  
pp. 194-199
Author(s):  
Wioletta Ratajczak-Wrona ◽  
Ewa Jablonska
Keyword(s):  
Nitric Oxide ◽  
Signaling Pathways ◽  
Molecular Mechanisms ◽  
Polymorphonuclear Neutrophils ◽  
Microbial Pathogens ◽  
Human Neutrophils ◽  
No Production ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Background: Polymorphonuclear neutrophils (PMNs) play a crucial role in the innate immune system’s response to microbial pathogens through the release of reactive nitrogen species, including Nitric Oxide (NO). </P><P> Methods: In neutrophils, NO is produced by the inducible Nitric Oxide Synthase (iNOS), which is regulated by various signaling pathways and transcription factors. N-nitrosodimethylamine (NDMA), a potential human carcinogen, affects immune cells. NDMA plays a major part in the growing incidence of cancers. Thanks to the increasing knowledge on the toxicological role of NDMA, the environmental factors that condition the exposure to this compound, especially its precursors- nitrates arouse wide concern. Results: In this article, we present a detailed summary of the molecular mechanisms of NDMA’s effect on the iNOS-dependent NO production in human neutrophils. Conclusion: This research contributes to a more complete understanding of the mechanisms that explain the changes that occur during nonspecific cellular responses to NDMA toxicity.

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