scholarly journals Histone Deacetylase (HDAC) Inhibitor, Suberoylanilide Hydroxamic Acid (SAHA), Induces Apoptosis in Prostate Cancer Cell Lines via the Akt/FOXO3a Signaling Pathway

2017 ◽  
Vol 23 ◽  
pp. 5793-5802 ◽  
Author(s):  
Xuan-Yan Shi ◽  
Wei Ding ◽  
Tie-Qiu Li ◽  
Yi-Xiong Zhang ◽  
Shan-Chao Zhao
Keyword(s):  
Prostate Cancer ◽  
Signaling Pathway ◽  
Histone Deacetylase ◽  
Cell Lines ◽  
Cancer Cell ◽  
Hdac Inhibitor ◽  
Hydroxamic Acid ◽  
Prostate Cancer Cell ◽  
Suberoylanilide Hydroxamic Acid ◽  
Prostate Cancer Cell Lines

scholarly journals ZFP91: A Noncanonical NF-κB Signaling Pathway Regulator with Oncogenic Properties Is Overexpressed in Prostate Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Lukasz Paschke ◽  
Karol Jopek ◽  
Marta Szyszka ◽  
Marianna Tyczewska ◽  
Agnieszka Ziolkowska ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Biology ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Mrna Levels ◽  
Prostate Cancer Cell Lines

Novel molecular targets are being searched to aid in prostate cancer diagnosis and therapy. Recently, ZFP91 zinc finger protein has been found to be upregulated in prostate cancer cell lines. It is a potentially important oncogenic protein; however only limited data regarding its biological function and expression patterns are available. To date, ZFP91 has been shown to be a key factor in activation of noncanonical NF-κB signaling pathway as well as to be involved in HIF-1α signaling in cancer cells. The present study aimed to characterize ZFP91 expression in prostate cancer specimens. Furthermore, since our earlier reports showed discrepancies between ZFP91 mRNA and protein levels, we studied this interrelationship in LNCaP and PC-3 prostate cancer cell lines using siRNA mediated knockdown. QPCR analysis revealed marked upregulation of ZFP91 mRNA in the majority of prostate cancer specimens. Transfection of prostate cancer cells with ZFP91 siRNA resulted in a 10-fold decrease in mRNA levels. On a protein level, however, no inhibitory effect was observed over the time of the cell culture. We conclude that ZFP91 is overexpressed in prostate cancer and that potential accumulation of the ZFP91 protein in studied cells may be of importance in prostate cancer biology.

Pomegranate Juice and Peel Extracts are Able to Inhibit Proliferation, Migration and Colony Formation of Prostate Cancer Cell Lines and Modulate the Akt/mTOR/S6K Signaling Pathway

2019 ◽  
Vol 75 (1) ◽  
pp. 54-62 ◽  
Author(s):  
Fernanda Machado Chaves ◽  
Isadora Carolina Betim Pavan ◽  
Luiz Guilherme Salvino da Silva ◽  
Lidia Broglio de Freitas ◽  
Mauricio Ariel Rostagno ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Signaling Pathway ◽  
Cell Lines ◽  
Cancer Cell ◽  
Colony Formation ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Pomegranate Juice ◽  
Prostate Cancer Cell Lines

scholarly journals Targeting prostate cancer cell lines with polo‐like kinase 1 inhibitors as a single agent and in combination with histone deacetylase inhibitors

2013 ◽  
Vol 27 (10) ◽  
pp. 4279-4293 ◽  
Author(s):  
Michel D. Wissing ◽  
Janet Mendonca ◽  
Madeleine S. Q. Kortenhorst ◽  
Nadine S. Kaelber ◽  
Matthew Gonzalez ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Histone Deacetylase ◽  
Cell Lines ◽  
Cancer Cell ◽  
Histone Deacetylase Inhibitors ◽  
Prostate Cancer Cell ◽  
Single Agent ◽  
Cancer Cell Lines ◽  
Prostate Cancer Cell Lines

797: Noggin Blocks the Osteoinductive Properties of Human Prostate Cancer Cell Lines

2006 ◽  
Vol 175 (4S) ◽  
pp. 258-258
Author(s):  
Ruth Schwaninger ◽  
Cyrill A. Rentsch ◽  
Antoinette Wetterwald ◽  
Irena Klima ◽  
Gabri Van der Pluijm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Prostate Cancer Cell Lines

Expression of Urokinase and Its Receptor in Invasive and Non-Invasive Prostate Cancer Cell Lines

1992 ◽  
Vol 68 (06) ◽  
pp. 662-666 ◽  
Author(s):  
W Hollas ◽  
N Hoosein ◽  
L W K Chung ◽  
A Mazar ◽  
J Henkin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Steady State ◽  
Cell Surface ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Lncap Cells ◽  
Prostate Cancer Cell Lines ◽  
Non Invasive

SummaryWe previously reported that extracellular matrix invasion by the prostate cancer cell lines, PC-3 and DU-145 was contingent on endogenous urokinase being bound to a specific cell surface receptor. The present study was undertaken to characterize the expression of both urokinase and its receptor in the non-invasive LNCaP and the invasive PC-3 and DU-145 prostate cells. Northern blotting indicated that the invasive PC-3 cells, which secreted 10 times more urokinase (680 ng/ml per 106 cells per 48 h) than DU-145 cells (63 ng/ml per 106 cells per 48 h), had the most abundant transcript for the plasminogen activator. This, at least, partly reflected a 3 fold amplification of the urokinase gene in the PC-3 cells. In contrast, urokinase-specific transcript could not be detected in the non-invasive LNCaP cells previously characterized as being negative for urokinase protein. Southern blotting indicated that this was not a consequence of deletion of the urokinase gene. Crosslinking of radiolabelled aminoterminal fragment of urokinase to the cell surface indicated the presence of a 51 kDa receptor in extracts of the invasive PC-3 and DU-145 cells but not in extracts of the non-invasive LNCaP cells. The amount of binding protein correlated well with binding capacities calculated by Scatchard analysis. In contrast, the steady state level of urokinase receptor transcript was a poor predictor of receptor display. PC-3 cells, which were equipped with 25,000 receptors per cell had 2.5 fold more steady state transcript than DU-145 cells which displayed 93,000 binding sites per cell.

Sign in / Sign up

Export Citation Format

Share Document