scholarly journals Which Is the Ideal Marker for Early Atherosclerosis in Obstructive Sleep Apnea (OSA) – Carotid Intima-Media Thickness or Mean Platelet Volume?

2017 ◽  
Vol 23 ◽  
pp. 1674-1681 ◽  
Author(s):  
Nurhan Sarioglu ◽  
Gulen Demirpolat ◽  
Fuat Erel ◽  
Mehmet Kose
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Mean Platelet Volume ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Platelet Volume ◽  
Media Thickness ◽  
Obstructive Sleep ◽  
Early Atherosclerosis ◽  
The Ideal

scholarly journals Circulating Lipopolysaccharide-Binding Protein and Carotid Intima-Media Thickness in Obstructive Sleep Apnea

2018 ◽  
pp. 69-78 ◽  
Author(s):  
I. TROJOVA ◽  
M. KOZAROVA ◽  
D. PETRASOVA ◽  
Z. MALACHOVSKA ◽  
I. PARANICOVA ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Lipopolysaccharide Binding Protein ◽  
Media Thickness ◽  
Obstructive Sleep ◽  
Metabolic Endotoxemia ◽  
Lipopolysaccharide Binding ◽  
Early Atherosclerosis

Circulating lipopolysaccharide-binding protein (LBP), a metabolic endotoxemia marker, was identified as an independent predictor of atherosclerosis. Although increases in carotid intima-media thickness (CIMT) were repeatedly reported in obstructive sleep apnea (OSA), neither the role of OSA in metabolic endotoxemia nor of LBP in early atherosclerosis were explored in patients with OSA. At a tertiary university hospital we investigated the relationships between OSA, LBP and CIMT in 117 men who underwent full polysomnography and CIMT assessment by B-mode ultrasound. Circulating LBP concentrations and average CIMT increased from patients without OSA to those with mild-moderate and severe OSA (from 32.1±10.3 to 32.3±10.9 to 38.1±10.3 μg.ml-1, p=0.015; from 0.52±0.09 to 0.58±0.06 to 0.62±0.10 mm, p=0.004, respectively). Oxygen desaturation index (ODI) was a predictor of serum LBP levels independent of age, waist-to-hip ratio (WHR), smoking, hypertension, HDL cholesterol, triglycerides and fasting glucose [p (ANOVA)=0.002, r2=0.154], with no independent effect of the ODI*WHR interaction term on LBP. Furthermore, serum LBP predicted CIMT independently of known risk factors of atherosclerosis including obesity (p<0.001, r2=0.321). Our results suggest that OSA severity contributes to metabolic endotoxemia in patients with OSA independently of obesity, and that LBP might represent a contributing factor promoting early atherosclerosis in such patients.

Endothelial function and carotid intima media thickness in obstructive sleep apnea without comorbidity

2016 ◽  
Vol 21 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Faraz A. Farooqui ◽  
Surendra K. Sharma ◽  
Atin Kumar ◽  
Manish Soneja ◽  
Kalaivani Mani ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Endothelial Function ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Obstructive Sleep

Aortic Stiffness, Flow-Mediated Dilatation and Carotid Intima-Media Thickness in Obstructive Sleep Apnea

Respiration ◽  
2006 ◽  
Vol 73 (6) ◽  
pp. 741-750 ◽  
Author(s):  
Halil Tanriverdi ◽  
Harun Evrengul ◽  
Cuneyt Orhan Kara ◽  
Omur Kuru ◽  
Seyhan Tanriverdi ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Aortic Stiffness ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Obstructive Sleep ◽  
Flow Mediated Dilatation

scholarly journals Obstructive Sleep Apnea, Sleep Duration, and Associated Mediators With Carotid Intima-Media Thickness

2021 ◽  
Author(s):  
Silvana P. Souza ◽  
Ronaldo B. Santos ◽  
Itamar S. Santos ◽  
Barbara K. Parise ◽  
Soraya Giatti ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Duration ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
R Package ◽  
Apnea Hypopnea Index ◽  
Sleep Study ◽  
Media Thickness ◽  
Obstructive Sleep

Objective: To elucidate the independent associations of obstructive sleep apnea (OSA) and sleep duration (SD) as well as the potential inflammatory and metabolic mediators on carotid intima-media thickness (CIMT) in a large cohort of adults. Approach and Results: Consecutive participants from the ELSA-Brasil performed a clinical evaluation, sleep study, 1-week actigraphy for defining SD and CIMT using standard techniques. Gamma regression models were used to explore the association between OSA and SD with CIMT. Mediation analysis was performed using the mediation R package. A total of 2009 participants were included in the main analysis. As compared with no OSA (apnea-hypopnea index [AHI] <5 events/hour; n=613), patients with mild (AHI, 5–14.9; n=741), moderate (AHI, 15–29.9; n=389), and severe OSA (AHI ≥30 events/hour; n=266) presented a progressive CIMT increase (0.690 [0.610–0.790], 0.760 [0.650–0.890], 0.810 [0.700–0.940], and 0.820 [0.720–0.958] mm; P <0.001). In contrast, CIMTs were similar for those with SD <6 hours (0.760 [0.650–0.888]), 6 to 8 hours (0.750 [0.640–0.880]) and >8 hours (0.740 [0.670–0.900]). All forms of OSA were independently associated with CIMT (mild: β: 0.019, SE 0.008; P =0.022; moderate: β: 0.025, SE 0.011; P =0.022; severe OSA: β: 0.040, SE 0.013; P =0.002). Moreover, the association of AHI with CIMT was mediated by increased C-reactive protein and triglycerides ( P <0.01). SD did not interact with OSA in the association with CIMT. Conclusions: OSA is independently associated with increased CIMT in a dose-response relationship. This association is partially mediated by inflammation and dyslipidemia. In contrast, SD is not associated nor interacted with OSA to increase CIMT.

Influence of obstructive sleep apnea on ischemia-modified albumin levels and carotid intima-media thickness

2016 ◽  
Vol 64 (5) ◽  
pp. 1035-1041 ◽  
Author(s):  
Harun Karamanli ◽  
Aysel Kiyici ◽  
Bilal Arik ◽  
Duran Efe ◽  
Recep Akgedik
Keyword(s):  
Oxidative Stress ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Control Group ◽  
Ischemia Modified Albumin ◽  
Media Thickness ◽  
Obstructive Sleep ◽  
Increased Risk

Obstructive sleep apnea (OSA) is associated with an increased risk of atherosclerosis. Carotid intima-media thickness (CIMT) is strongly associated with the presence of significant risk factors for cardiovascular disturbances. A disturbance in the oxidative/antioxidative balance is involved in the pathogenesis of OSA and cardiovascular diseases. Ischemia-modified albumin (IMA) is suggested as a novel marker of oxidative stress; IMA can be defined as decreased binding of transitional metal ions to serum albumin in oxidative status. The purpose of this research was to evaluate the influence of OSA on IMA levels and CIMT. In total, 61 individuals with OSA with no comorbidities and 24 healthy controls with a similar body mass index and age were enrolled in this study. Serum levels of IMA, CIMT (estimated radiologically), and polysomnographic parameters, were determined and interpreted. Serum IMA levels were significantly higher in individuals with OSA compared with the control group (p=0.0003). CIMT was significantly higher in the OSA group compared with the control group (0.88± 0.26 mm vs 0.75±0.17 mm, p=0.005). The CIMT and serum IMA levels were positively correlated with the apnea-hypopnea index (r=0.35 and r=0.32, respectively), and with the oxygen desaturation index (r=0.34 and r=0.29, respectively) at baseline. Increased IMA levels and CIMT may be related to increased oxidative stress and risk of atherosclerosis in individuals with OSA.

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