scholarly journals P53 Regulation-Association Long Non-Coding RNA (LncRNA PRAL) Inhibits Cell Proliferation by Regulation of P53 in Human Lung Cancer

2017 ◽  
Vol 23 ◽  
pp. 1751-1758 ◽  
Author(s):  
Pengxiao Su ◽  
Fengqin Wang ◽  
Bin Qi ◽  
Ting Wang ◽  
Shaobo Zhang
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Long non-coding RNA EPIC1 promotes human lung cancer cell growth

2018 ◽  
Vol 503 (3) ◽  
pp. 1342-1348 ◽  
Author(s):  
Bing Zhang ◽  
Hui-Yu Lu ◽  
Yun-Hong Xia ◽  
Ai-Gui Jiang ◽  
Yu-Xin Lv
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Human Lung Cancer Cell ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1

2020 ◽  
Vol 40 (1) ◽  
Author(s):  
Yafeng Fan ◽  
Hongxia Li ◽  
Zhongping Yu ◽  
Wen Dong ◽  
Xiaoyan Cui ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Small Cell Lung Cancer ◽  
Cancer Cell ◽  
Small Cell ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Abstract Long non-coding RNA (lncRNA) FYVE, RhoGEF and PH domain containing 5 antisense RNA 1 (FGD5-AS1) has been reported as an oncogene in colorectal cancer, promoting its tumorgenesis. The present paper focused on searching the potential function of FGD5-AS1 in non-small cell lung carcinoma (NSCLC). There are connections between the expression of lncRNA FGD5-AS1 and human NSCLC tumor growth and progression. Also, the relationships between FGD5-AS1, hsa-miR-107 and mRNA fibroblast growth factor receptor like 1 (FGFRL1) are going to test their interaction in NSCLC cell lines, which may cause a series of biological behaviors of NSCLC cells. qRT-PCR analysis was conducted to test the expression of RNAs in different situation. CCK-8 experiment and clone formation assay were performed to assess proliferation of NSCLC cells. Also, connection between FGD5-AS1 and hsa-miR-107 were investigated by luciferase reporter assay and RNA pull-down assay. Rescue experiments were performed to verify the modulating relationship between FGD5-AS1, hsa-miR-107 and FGFRL1. High-level expression of FGD5-AS1 was found in NSCLC. FGD5-AS1 may promote the proliferation of NSCLC cells. Also, the combination between hsa-miR-107, FGD5-AS1 and NSCLC have been proved, which means they can play an interaction function in NSCLC cells. Thence, we concluded that lncRNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1.

The novel microRNA hsa-miR-CHA1 regulates cell proliferation and apoptosis in human lung cancer by targeting XIAP

Lung Cancer ◽  
2019 ◽  
Vol 132 ◽  
pp. 99-106 ◽  
Author(s):  
Jung Ki Yoo ◽  
Ji Min Lee ◽  
Seung Hee Kang ◽  
Seong Ho Jeon ◽  
Chang Min Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Human Lung ◽  
Human Lung Cancer ◽  
The Novel ◽  
Proliferation And Apoptosis
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