scholarly journals Combretastatin A4 Regulates Proliferation, Migration, Invasion, and Apoptosis of Thyroid Cancer Cells via PI3K/Akt Signaling Pathway

2016 ◽  
Vol 22 ◽  
pp. 4911-4917 ◽  
Author(s):  
Weixin Liang ◽  
Yongqiang Lai ◽  
Mingzhang Zhu ◽  
Shangshu Huang ◽  
Weizhao Feng ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Combretastatin A4 ◽  
Thyroid Cancer Cells

scholarly journals Autophagy Modulation in Human Thyroid Cancer Cells following Aloperine Treatment

2019 ◽  
Vol 20 (21) ◽  
pp. 5315 ◽  
Author(s):  
Hui-I Yu ◽  
Hui-Ching Shen ◽  
Shu-Hsin Chen ◽  
Yun-Ping Lim ◽  
Hsiang-Hsun Chuang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Human Thyroid ◽  
Osteosarcoma Cell ◽  
Apoptosis Induction ◽  
Akt Signaling Pathway ◽  
Antitumor Effects ◽  
Thyroid Cancer Cells

Aloperine, an alkaloid isolated from Sophora alopecuroides, exhibits multiple pharmacological activities including anti-inflammatory, antioxidant, antiallergic, antinociceptive, antipathogenic, and antitumor effects. Furthermore, it exerts protective effects against renal and neuronal injuries. Several studies have reported antitumor effects of aloperine against various human cancers, including multiple myeloma; colon, breast, and prostate cancers; and osteosarcoma. Cell cycle arrest, apoptosis induction, and tumorigenesis suppression have been demonstrated following aloperine treatment. In a previous study, we demonstrated antitumor effects of aloperine on human thyroid cancer cells through anti-tumorigenesis and caspase-dependent apoptosis induction via the Akt signaling pathway. In the present study, we demonstrated the modulation of the autophagy mechanism following the incubation of multidrug-resistant papillary and anaplastic human thyroid cancer cells with aloperine; we also illustrate the underlying mechanisms, including AMPK, Erk, JNK, p38, and Akt signaling pathways. Further investigation revealed the involvement of the Akt signaling pathway in aloperine-modulated autophagy in human thyroid cancer cells. These results indicate a previously unappreciated function of aloperine in autophagy modulation in human thyroid cancer cells.

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