scholarly journals Plasma Inflammatory Cytokine IL-4, IL-8, IL-10, and TNF-α Levels Correlate with Pulmonary Function in Patients with Asthma-Chronic Obstructive Pulmonary Disease (COPD) Overlap Syndrome

2016 ◽  
Vol 22 ◽  
pp. 2800-2808 ◽  
Author(s):  
Ai-Xia Huang ◽  
Li-Wen Lu ◽  
Wen-Juan Liu ◽  
Mao Huang
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Inflammatory Cytokine ◽  
Overlap Syndrome ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Tnf Α

scholarly journals Therapeutic Effect Observation of Tiotropium Bromide in the Treatment of Overlap Syndrome

2020 ◽  
Vol 3 (1) ◽  
pp. 15
Author(s):  
Yunchao Huang ◽  
Ting Wang
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Sleep Apnea ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Overlap Syndrome ◽  
Tiotropium Bromide ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Obstructive Sleep

Objective: To study the M receptor blocker on inhalation in patients with overlap syndrome (chronic obstructive pulmonary disease and Obstructive sleep apnea syndrome) curative effect analysis. Methods: 25 patients with overlap syndrome as the experimental group, chronic obstructive pulmonary disease patients (30) as control group, patients with overlap syndrome use inhaled tiotropium powder treat 30 days, to observe the changes of pulmonary function, polysomnography, and other indicators after treatment. Results: Overlap syndrome were treated by tiotropium bromide inhalation powder, has improved the pulmonary function, the sleep apnea index and lowest nocturnal oxygen saturation after treatment. Conclusion: tiotropium bromide has a preferable effective in treatment of overlap syndrome, COPD and OSAHS are interacting with each other.

scholarly journals Long-Term Effects of Acupuncture Treatment on Airway Smooth Muscle in a Rat Model of Smoke-Induced Chronic Obstructive Pulmonary Disease

2016 ◽  
Vol 34 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Jia Li ◽  
Song Wu ◽  
Hongtu Tang ◽  
Wei Huang ◽  
Lushan Wang ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Rat Model ◽  
Acupuncture Treatment ◽  
Chronic Obstructive ◽  
Long Term Effects ◽  
Obstructive Pulmonary Disease ◽  
Histone Deacetylase 2 ◽  
Tnf Α

Background Chronic obstructive pulmonary disease (COPD) is one of the most common lung diseases. It is a chronic inflammatory process characterised by airway obstruction and progressive lung inflammation, associated with difficulty breathing and insensitivity to corticosteroid therapy. Although there is some preliminary evidence to suggest a beneficial effect of acupuncture on COPD, its mechanism of action has not been investigated. Our aim was to examine the anti-inflammatory effects of acupuncture in a rat model of COPD induced by exposure to cigarette smoke (CS). Methods Sixty Sprague–Dawley rats were exposed to the smoke of 15 cigarettes for 1 h/day, 6 days/week for 3 months to induce COPD and treated with acupuncture at BL13 ( Feishu), BL23 ( Shenshu) and Dingchuan (COPD+Acupuncture, n=15), sham acupuncture (COPD+Sham, n=15) or left untreated (n=15). Exposed rats were compared with controls not exposed to CS (control, n=15). Pulmonary function was measured, and tumour necrosis factor-α (TNF-α) and interleukin-8 (IL-8) levels were determined in bronchoalveolar lavage fluid by ELISA. Histone deacetylase 2 (HDAC2) protein and mRNA expression were examined in lung tissue and in bronchus. Results Acupuncture treatment appeared to protect pulmonary function and reduce the COPD-induced inflammatory response by decreasing cell inflammation and the production of TNF-α and IL-8. Acupuncture also enhanced HDAC2 mRNA and protein expression, suggesting a possible direct effect on protein structure through post-translational modifications. Conclusions Our results suggest that acupuncture regulates inflammatory cytokines and contributes to lung protection in a rat model of smoke-induced COPD by modulating HDAC2.

Sign in / Sign up

Export Citation Format

Share Document