scholarly journals Low Pretreatment Acoustic Radiation Force Impulse Imaging (ARFI) Values Predict Sustained Virological Response in Antiviral Hepatitis C Virus (HCV) Therapy

2016 ◽  
Vol 22 ◽  
pp. 3500-3505 ◽  
Author(s):  
Steffen Zopf ◽  
Lara Rösch ◽  
Peter C. Konturek ◽  
Ruediger S. Goertz ◽  
Markus F. Neurath ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Acoustic Radiation Force Impulse ◽  
Hcv Therapy

Study of hepatic stiffness in hepatitis C virus-related liver diseases by acoustic radiation force impulse imaging

2014 ◽  
Vol 4 (3) ◽  
pp. 79-82
Author(s):  
El Said H. Ibrahim ◽  
Ashraf N. Ettaby ◽  
Fathallah S. Mohamed ◽  
Perihan E. Salem ◽  
Sarah F. Massoud
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Diseases ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Acoustic Radiation Force Impulse

Performance of Acoustic Radiation Force Impulse Elastography for Staging Liver Fibrosis in Patients With Chronic Hepatitis C After Viral Eradication

2019 ◽  
Vol 70 (1) ◽  
pp. 114-122 ◽  
Author(s):  
Sheng-Hung Chen ◽  
Hsueh-Chou Lai ◽  
I-Ping Chiang ◽  
Wen-Pang Su ◽  
Chia-Hsin Lin ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Acoustic Radiation Force Impulse ◽  
Viral Eradication ◽  
Arfi Elastography

Abstract Background Data on noninvasive liver fibrosis staging after viral eradication are unclear. This histology-based study validated the performance of liver stiffness (LS) measurements after viral eradication. Methods Consecutive participants with chronic hepatitis C (CHC) who received concomitant LS measurements through acoustic radiation force impulse (ARFI) elastography and percutaneous liver biopsy were prospectively screened and analyzed. Results Of the 644 patients, 521 (80.9%) underwent a biopsy at treatment baseline, and the remaining 123 (19.1%) underwent a biopsy at 3 years (median; interquartile range, 0.1) after the sustained virological response (SVR) to pegylated interferon–based and direct-acting antiviral treatments. The proportions of histological fibrosis stages did not differ significantly between the pretreatment and post-SVR groups (P = .0615). However, the LS values differed significantly (P < .0001). The median LS values (presented as shear wave velocities in meters per second) were 1.51 (0.92) for the pretreatment group and 1.22 (0.77) for the post-SVR group. The cutoffs (areas under the receiver operating characteristic curve, obtained using the bootstrap method) to dichotomize between METAVIR fibrosis stage F1 versus stages F2–F4, F1–F2 versus F3–F4, and F1–F3 versus F4 were 1.47 (0.8333, 95% confidence interval [CI] 0.7981–0.8663), 1.81 (0.8763, 95% CI 0.8376–0.9107), and 1.86 (0.8811, 95% CI 0.8378–0.9179) in the pretreatment group, respectively, and 1.22 (0.7872, 95% CI 0.7001–0.8624), 1.59 (0.8808, 95% CI 0.8034–0.9422), and 1.75 (0.9018, 95% CI 0.8201–0.9644) in the post-SVR group, respectively. Conclusions The performance of LS measurements through ARFI elastography is promising to determine the liver fibrosis stage on necroinflammation-resolved histology in CHC after viral eradication.

scholarly journals Acoustic radiation force impulse (ARFI) elastography compared with biopsy for evaluating hepatic fibrosis after liver transplantation: a cross-sectional diagnostic study

2016 ◽  
Vol 134 (6) ◽  
pp. 513-518 ◽  
Author(s):  
Joel Schmillevitch ◽  
◽  
Maria Cristina Chammas ◽  
Vincenzo Pugliese ◽  
Edson Abdala ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis C ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Acoustic Radiation Force Impulse ◽  
Diagnostic Study ◽  
Cross Sectional ◽  
Significant Difference ◽  
Arfi Elastography

ABSTRACT CONTEXT AND OBJECTIVE: Biopsies are used after liver transplantation to evaluate fibrosis. This study aimed to evaluate the elasticity of transplanted livers by means of a non-invasive examination, acoustic radiation force imaging (ARFI) elastography, correlating the results with the histological analysis. DESIGN AND SETTING: Cross-sectional study in a public university hospital. METHODS: All patients consecutively operated between 2002 and 2010 with an indication for biopsy were evaluated by means of elastography. The radiologist evaluating ARFI and the pathologist doing anatomopathological examinations were blinded to each other's evaluations. RESULTS: During the study period, 33 patients were included. The indication for transplantation was cirrhosis due to hepatitis C in 21 cases (63%). Liver biopsies showed absence of fibrosis (F0) in 10 patients, F1 in 11, F2 in 8 and F3 in 4. There were no cases of F4 (cirrhosis). The difference in ARFI values (degree of fibrosis) was 0.26 (95% confidence interval, CI: 0.07-0.52) between the groups F0-F1 and F2-F4 (P = 0.04). An area under the curve of 0.74 (CI: 0.55-0.94) and a cutoff of 1.29 m/s between the groups resulted in the best relationship between sensitivity and specificity. Sensitivity (0.66; CI: 0.50-0.83) was lower than specificity (0.85; CI: 0.72-0.97). There was no significant difference in ARFI between patients with hepatitis C and those with other diseases. CONCLUSIONS: The values obtained from elastography were not affected by inflammatory reaction or anatomical alterations. A cutoff point of 1.29 m/s separating patients with or without significant fibrosis was identified.

scholarly journals ACOUSTIC RADIATION FORCE IMPULSE IS EQUIVALENT TO LIVER BIOPSY TO EVALUATE LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS C AND NONALCOHOLIC FATTY LIVER DISEASE

2015 ◽  
Vol 52 (3) ◽  
pp. 234-238 ◽  
Author(s):  
Juliana Ayres de Alencar Arrais GUERRA ◽  
Marcus TRIPPIA ◽  
Alcindo PISSAIA JUNIOR ◽  
Bernardo Corrêa de Almeida TEIXEIRA ◽  
Cláudia Alexandra Pontes IVANTES
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Acoustic Radiation Force Impulse ◽  
Nonalcoholic Fatty Liver

BackgroundLiver biopsy is recommended as the gold standard method for assessing the stage of liver fibrosis in patients with chronic liver disease. However, it is invasive, with potential risks and complications. Elastography is an ultrasound technique that provides information of changes in the liver tissue, evaluating tissue elasticity and acoustic radiation force impulse is one of the available techniques.ObjectiveThe main objective of this study was to evaluate the sensitivity and specificity of acoustic radiation force impulse comparing to liver biopsy to evaluate fibrosis in patients with chronic hepatitis C virus and nonalcoholic fatty liver disease.MethodsTwenty four patients were included, everyone underwent liver biopsy and acoustic radiation force impulse, and the results were compared with values described in the literature by several authors.ResultsIn the population of patients with chronic hepatitis C, our data were better correlated with data published by Carmen Fierbinteanu-Braticevici et al., with an accuracy of 82.4%, sensitivity of 71.4% and specificity of 90%. For nonalcoholic fatty liver disease, our data were better correlated with data published by Masato Yoneda et al., with an accuracy of 85.7%, sensitivity 80% and specificity of 100%.ConclusionAcoustic radiation force impulse is a method with good accuracy to distinguish initial fibrosis from advanced fibrosis in hepatitis C virus and nonalcoholic fatty liver disease and can replace biopsy in most cases.

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