scholarly journals TXNIP Suppresses Expression of Glutamine Synthetase by Inducing Oxidative Stress in Retinal Muller Glia Under Diabetic Conditions

2016 ◽  
Vol 22 ◽  
pp. 1460-1466 ◽  
Author(s):  
Jia Zhou ◽  
Xi Shen ◽  
Qiong Lu ◽  
Min Zhang
Keyword(s):  
Oxidative Stress ◽  
Glutamine Synthetase ◽  
Muller Glia ◽  
Müller Glia

scholarly journals TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy

2012 ◽  
Vol 2012 ◽  
pp. 1-19 ◽  
Author(s):  
Takhellambam S. Devi ◽  
Icksoo Lee ◽  
Maik Hüttemann ◽  
Ashok Kumar ◽  
Kwaku D. Nantwi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Er Stress ◽  
Host Defense ◽  
Defense Mechanisms ◽  
Immune Response Gene ◽  
Ros Generation ◽  
Muller Glia ◽  
Müller Glia ◽  
Cellular Defense

Thioredoxin Interacting Protein (TXNIP) mediates retinal inflammation, gliosis, and apoptosis in experimental diabetes. Here, we investigate the temporal response of Muller glia to high glucose (HG) and TXNIP expression using a rat Muller cell line (rMC1) in culture. We examined if HG-induced TXNIP expression evokes host defense mechanisms in rMC1 in response to metabolic abnormalities. HG causes sustained up-regulation of TXNIP (2 h to 5 days), ROS generation, ATP depletion, ER stress, and inflammation. Various cellular defense mechanisms are activated by HG: (i) NLRP3 inflammasome, (ii) ER stress response (sXBP1), (iii) hypoxic-like HIF-1αinduction, (iv) autophagy/mitophagy, and (v) apoptosis. We also foundin vivothat streptozocin-induced diabetic rats have higher retinal TXNIP and innate immune response gene expression than normal rats. Knock down of TXNIP by intravitreal siRNA reduces inflammation (IL-1β) and gliosis (GFAP) in the diabetic retina. TXNIP ablationin vitroprevents ROS generation, restores ATP level and autophagic LC3B induction in rMC1. Thus, our results show that HG sustains TXNIP up-regulation in Muller glia and evokes a program of cellular defense/survival mechanisms that ultimately lead to oxidative stress, ER stress/inflammation, autophagy and apoptosis. TXNIP is a potential target to ameliorate blinding ocular complications of diabetic retinopathy.

Müller Glia-Mediated Retinal Regeneration

2021 ◽  
Author(s):  
Hui Gao ◽  
Luodan A ◽  
Xiaona Huang ◽  
Xi Chen ◽  
Haiwei Xu
Keyword(s):  
Muller Glia ◽  
Müller Glia ◽  
Retinal Regeneration

Müller glia–myeloid cell crosstalk accelerates optic nerve regeneration in the adult zebrafish

Glia ◽  
2021 ◽  
Author(s):  
Annelies Van Dyck ◽  
Ilse Bollaerts ◽  
An Beckers ◽  
Sophie Vanhunsel ◽  
Nynke Glorian ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Myeloid Cell ◽  
Muller Glia ◽  
Müller Glia ◽  
Adult Zebrafish ◽  
Optic Nerve Regeneration ◽  
Cell Crosstalk

d-Serine regulates CREB phosphorylation induced by NMDA receptor activation in Müller glia from the retina

2007 ◽  
Vol 427 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Mónica Lamas ◽  
Irene Lee-Rivera ◽  
Mónica Ramírez ◽  
Ana María López-Colomé
Keyword(s):  
Nmda Receptor ◽  
Receptor Activation ◽  
Muller Glia ◽  
Müller Glia ◽  
Creb Phosphorylation ◽  
Nmda Receptor Activation

Glutamate Receptor Stimulation Up-Regulates Glutamate Uptake in Human Müller Glia Cells

2016 ◽  
Vol 41 (7) ◽  
pp. 1797-1805 ◽  
Author(s):  
Ana María López-Colomé ◽  
Edith López ◽  
Orquidia G. Mendez-Flores ◽  
Arturo Ortega
Keyword(s):  
Glutamate Receptor ◽  
Glutamate Uptake ◽  
Muller Glia ◽  
Müller Glia ◽  
Receptor Stimulation ◽  
Glia Cells
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