scholarly journals Combined Use of Etomidate and Dexmedetomidine Produces an Additive Effect in Inhibiting the Secretion of Human Adrenocortical Hormones

2015 ◽  
Vol 21 ◽  
pp. 3528-3535 ◽  
Author(s):  
Hongbin Gu ◽  
Mazhong Zhang ◽  
Meihua Cai ◽  
Jinfen Liu
Keyword(s):  
Additive Effect ◽  
Adrenocortical Hormones ◽  
Combined Use

scholarly journals In Vitro Antibacterial Activity of Galla Chinensis Combined with Different Antibacterial Drugs against Carbapenem-Resistant E.Coli

2019 ◽  
Vol 2 (4) ◽  
pp. 15
Author(s):  
Zhizhi Xie ◽  
Changzhi Xu ◽  
Yanhua Yi ◽  
Donglin Zhu ◽  
Yun Xi
Keyword(s):  
Antibacterial Activity ◽  
Synergistic Effect ◽  
Antimicrobial Agents ◽  
Additive Effect ◽  
Dilution Method ◽  
Antagonistic Effects ◽  
Carbapenem Resistant ◽  
Combined Use ◽  
In Vitro Antibacterial Activity

Objective: To evaluate the antibacterial effects of meropenem and levofloxacin respectively combined with Galla chinensis on carbapenem-resistant Escherichia coli in vitro. Methods： The protocol was designed with checkerboard method and the carbapenem-resistant E.coli was isolated in our hospital. The minimum inhibitory concentrations(MICs) of G. chinensis alone and combined with 2 antimicrobial agents against carbapenem-resistant E.coli were determined by broth dilution method and the fractional inhibitory concentration index (FICI) was calculated according to MICs results. Result： the combined use of G. chinensis and meropenem (or levofloxacin) significantly decreased both MIC50 and MIC90; After the combination of G. chinensis and meropenem, the synergistic effect was 86.7%, and the additive effect was 13.3%, no irrelevant and antagonistic effects. After combined use of G. chinensis and levofloxacin, the synergistic effect was 66.7%, and the additive effect was 33.3%. No irrelevant and antagonistic effects. Conclusion： Galla chinensis combined with meropenem or levofloxacin has synergistic and additive antibacterial effect, with certain combined antibacterial activity.

PSI-B-24 Assessment of the combined use of antibacterial substances on the in vitro model in the development of veterinary drugs

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 226-226
Author(s):  
Zhanara Sulimenova ◽  
Yulia Plotnikova ◽  
Alexey Sizentsov ◽  
Elena Barysheva ◽  
Elena Bibartseva
Keyword(s):  
Growth Suppression ◽  
Additive Effect ◽  
Diffusion Method ◽  
Bark Extract ◽  
Antibacterial Drugs ◽  
Chemotherapy Drugs ◽  
Combined Use ◽  
Test Organisms ◽  
Probiotic Strains ◽  
Selection Of

Abstract The wide use of antibacterial drugs in the agricultural and veterinary industries as growth stimulants and antimicrobial therapies has led to increased resistance of pathogens and opportunistic pathogens to many chemotherapy drugs. The purpose of our study is to assess the additive effect of these compounds to enhance the inhibitory action of antibiotics. Antibacterial drugs of various chemical groups, extracts from medicinal plants with microbicide and anti-quorum effects, inorganic copper and zinc salts, as well as probiotic strains of the genus Bacillus of veterinary purpose, were used to achieve the goal. The main methodical approach to assessing the additive effect of complex compounds in the work was the method of diffusion into agar, combined with the method of serial dilution. The selection of antibacterial drugs was carried out using the disk diffusion method. S. enteritidis, S. typhimurium, and P. aeruginosa were used as the test organisms in studies. The main criterion for the selection of antibacterial drugs was the resistance of probiotic strains and the moderate sensitivity of the test organisms in relation to their action. Cefixime was experimentally selected for the study against S. enteritidis and S. typhimurium and Fosfomycin against P. aeruginosa. Of all the studied phytobiotics, the most promising for further study was the oak bark extract. Against P. aeruginosa, the most significant chemical compound is CuSO4 at a concentration of 40 mg/ml, which does not affect the growth of probiotic strains. The pronounced additive effect of the combined compound based on cefixime, oak bark, and B. subtilis 534 was observed against S. enteritidis and S. typhimurium by 23% and 25%, respectively. The combined use of fosfomycin, B. subtilis 534, CuSO4, and the oak bark extract increases P. aeruginosa growth suppression by 19 % compared to the control of the growth suppression of this antibiotic.

Additive Effect of dDAVP and Standard Heparin inIncreasing Plasma t-PA

1989 ◽  
Vol 61 (03) ◽  
pp. 507-510 ◽  
Author(s):  
Giancarlo Agnelli ◽  
Marcel Levi ◽  
Benilde Cosmi ◽  
Jan Wouter ten Cate ◽  
Giuseppe G Nenci
Keyword(s):  
Healthy Volunteers ◽  
Bolus Dose ◽  
Specific Activity ◽  
Additive Effect ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Combined Use ◽  
The Difference ◽  
Pai 1 ◽  
Endogenous Fibrinolysis

SummaryThe aim of this study was to evaluate the existence of an additive effect between standard heparin and dDAVP in the enhancement of endogenous fibrinolysis. Eight healthy volunteers were studied in a randomized double blind placebo controlled cross-over trial. The volunteers were treated i. v. with dDAVP, 0.4 μg/kg, over 15 minutes followed by an i. v. bolus dose of either standard heparin, 5,000 I.U., or saline. A 48 hour wash-out period was adopted. The infusion of dDAVP followed by standard heparin resulted in a higher increase in plasma t-PA actiyity, t-PA antigen, circulating t-PA specific activity and FPLA when compared with dDAVP followed by saline. The difference was already statistically significant at 15 minutes after the infusion of dDAVP and lasted for up to 60 minutes after the end of the infusion of dDAVP. Plasma PAI 1 showed a slightly higher decrease after dDAVP plus standard heparin than after dDAVP plus saline but this difference was not statistically significant. No statistically significant changes of fibrinogen and α2-antiplasmin levels were observed. As expected, the infusion of standard heparin resulted in an increase in plasma anti-Xa activity and in a prolongation of aPTT Our results demonstrated an additive effect of dDAVP and standard heparin on the increase in circulating t-PA, the effect of dDAVP being potentiated and prolonged by heparin. This observation could prospect a combined use of dDAVP and standard heparin in the prophylaxis and treatment of thromboembolic diseases.

Platelet monitoring for PCI

2009 ◽  
Vol 29 (04) ◽  
pp. 376-380 ◽  
Author(s):  
D. Capodanno ◽  
D. J. Angiolillo
Keyword(s):  
Interindividual Variability ◽  
State Of The Art ◽  
Coronary Intervention ◽  
Functional Tests ◽  
Treatment Regimens ◽  
Advantages And Disadvantages ◽  
Coronary Syndrome ◽  
Combined Use ◽  
Increased Risk ◽  
Percutaneous Coronary

SummaryDespite the clinical benefit associated with the combined use of aspirin and clopidogrel in patients with acute coronary syndrome or those undergoing percutaneous coronary intervention, a considerable interindividual variability in response to these drugs have been consistently reported. There is a growing interest on applying platelet functional tests with the goal of identifying patients at increased risk of recurrent ischaemic events and potentially tailoring antiplatelet treatment regimens.This manuscript will review the state of the art on the most commonly available platelet functional tests, describing their advantages and disadvantages and exploring their applicability in clinical practice.

201Tl Scintigraphy in the Evaluation of Palpable and Nonpalpable Breast Lesions: Correlation with Mammography and Ultrasonography

1997 ◽  
Vol 36 (08) ◽  
pp. 282-288 ◽  
Author(s):  
T. Atasever ◽  
A. Özdemir ◽  
I. Öznur ◽  
N. I. Karabacak ◽  
N. Gökçora ◽  
...  
Keyword(s):  
Final Diagnosis ◽  
Lower Sensitivity ◽  
Breast Lesions ◽  
Breast Cancers ◽  
Combined Use ◽  
Malignant Breast ◽  
Malignant Lesions ◽  
Benign Breast Lesions ◽  
Palpable Breast ◽  
Metastatic Sites

Summary Aim: Our goal was to determine the clinical usefulness of TI-201 to identify breast cancer in patients with suspicious breast lesions on clinical examination, and/or abnormal radiologic (mammography and/or ultrasonography) findings. Methods: TI-201 scintigraphy were performed in sixty-eight patients with 70 breast abnormalities (51 palpable, 19 nonpalpable) and compared with mammography and ultrasonography (US). Early (15 min) and late (3 h) images of the breasts were obtained following the injection of 111 MBq (3 mCi) of TI-201. Visual and semiquantitative interpretation was performed. Results: Final diagnosis confirmed 52 malignant breast lesions and 18 benign conditions. TI-201 visualized 47 of 52 (90%) overall malignant lesions. Thirty-eight of 40 (95%) palpable and 9 of 12 (75%) nonpalpable breast cancers were detected by TI-201 scintigraphy. The smallest mass lesion detected by TI-201 measured 1.5x1.0 cm. Eleven breast lesions were interpreted as indeterminate by mammography and/or sonography. TI-201 scintigraphy excluded malignancy in 7 of 8 (88%) patients with benign breast lesions interpreted as indeterminate. Five of the 18 (28%) benign breast lesions showed TI-201 uptake. None of the fibroadenoma and fibrocystic changes accumulated TI-201. TI-201 scintigraphy, mammography and ultrasonography showed 90%, 92%, 85% overall sensitivity and 72%, 56%, 61% overall specificity respectively. Twenty-one of the 28 (75%) axillary nodal metastatic sites were also detected by TI-201. In malignant and benign lesions, early and late lesion/contralateral normal side (L/N) ratios were 1.58 ± 0.38 (mean ± SD) and 1.48 ± 0.32 (p >0.05), 1.87 ± 0.65 and 1.34 ± 0.20 (p<0.05) respectively. The mean early and late L/N ratios of malignant and benign groups did not show statistical difference (p>0.05). Conclusion: Overall, TI-201 scintigraphy was the most specific of the three methods and yielded favourable results in palpable breast cancers, while it showed lower sensitivity in nonpalpable cancers and axillary metastases. Combined use of TI-201 scintigraphy with mammography and US seems to be useful in difficult cases, such as dense breasts and indeterminate breast lesions.

Manual therapy and visual color-impulse therapy in the rehabilitation of patients with piriformis syndrome

2020 ◽  
pp. 95-101
Author(s):  
V. A. Frolov ◽  
M. S. Akopyan
Keyword(s):  
Manual Therapy ◽  
Muscle Tone ◽  
Randomized Study ◽  
Integrated Approach ◽  
Medical Rehabilitation ◽  
Piriformis Syndrome ◽  
Piriformis Muscle ◽  
Group I ◽  
Combined Use ◽  
Visual Color

Introduction. Piriformis syndrome (PS) is a condition accompanied by tension of the piriformis muscle and followed then by compression of the sciatic nerve passing through the piriformis muscle. According to statistics, PS occurs in 6–35 % of patients with lower back pain. Practitioners still face difficulties in treating patients with PS, and it necessitates the searching of new therapy methods and assessment of their compatibility.The goal of research — to study the clinical efficacy of the combined use of manual therapy and visual colorimpulse therapy in patients with piriformis syndrome.Materials and methods. A prospective, controlled, randomized study was conducted in 2019 at the Department of Sports Medicine and Medical Rehabilitation of I. M. Sechenov First Moscow Medical State University. In accordance with the inclusion criteria, 40 patients participated in the study. All participants, depending on the used treatment methodology, were divided by the method of simple randomization using envelopes into two equal groups. In the main group (group I), an integrated approach to treatment was tested: manual therapy in combination with visual color-impulse therapy (CIT); and in the other group (group II) only manual therapy was used.Results. The combined use of manual therapy and CIT in patients with piriformis syndrome leads to a significantly more pronounced decrease in the pain degree and normalization of impaired muscle tone. Also, an integrated approach helps to eliminate existing angiospastic disorders of the lower extremities.Conclusion. The study shows a clear positive dynamics in the integrated use of manual therapy methods in combination with visual color-impulse therapy in the treatment of patients with piriformis syndrome. It is planned to continue the study and assess the possibilities of using the combined technique in different groups of patients (athletes, pregnant women) with this syndrome. 

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