scholarly journals Transduced PEP-1-Heme Oxygenase-1 Fusion Protein Reduces Remote Organ Injury Induced by Intestinal Ischemia/Reperfusion

2015 ◽  
Vol 21 ◽  
pp. 1057-1065 ◽  
Author(s):  
Kai Chen
Keyword(s):  
Fusion Protein ◽  
Heme Oxygenase ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Organ Injury ◽  
Heme Oxygenase 1 ◽  
Remote Organ ◽  
Remote Organ Injury ◽  
Intestinal Ischemia Reperfusion

scholarly journals Orexigenic Hormone Ghrelin Attenuates Local and Remote Organ Injury after Intestinal Ischemia-Reperfusion

PLoS ONE ◽  
2008 ◽  
Vol 3 (4) ◽  
pp. e2026 ◽  
Author(s):  
Rongqian Wu ◽  
Weifeng Dong ◽  
Youxin Ji ◽  
Mian Zhou ◽  
Corrado P. Marini ◽  
...  
Keyword(s):  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Organ Injury ◽  
Remote Organ ◽  
Remote Organ Injury ◽  
Intestinal Ischemia Reperfusion

scholarly journals A Method to Detect Remote Organ Injury after Intestinal Ischemia-Reperfusion in Mice.

2002 ◽  
Vol 13 (3) ◽  
pp. 144-150
Author(s):  
Yuriko Matsuura ◽  
Kaoru Koike ◽  
Atsuko Tsujii ◽  
Saeed Samarghandian ◽  
Shigeki Kushimoto ◽  
...  
Keyword(s):  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Organ Injury ◽  
Remote Organ ◽  
Remote Organ Injury ◽  
Intestinal Ischemia Reperfusion

Effects of Thalidomide and Pentoxyphylline Over Local and Remote Organ Injury After Intestinal Ischemia/Reperfusion

2010 ◽  
Vol 42 (5) ◽  
pp. 1624-1626 ◽  
Author(s):  
C.R. Cámara-Lemarroy ◽  
F.J. Guzmán-de la Garza ◽  
G. Alarcón-Galván ◽  
P. Cordero-Pérez ◽  
L.E. Muñoz-Espinosa ◽  
...  
Keyword(s):  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Organ Injury ◽  
Remote Organ ◽  
Remote Organ Injury ◽  
Intestinal Ischemia Reperfusion

Intestinal preconditioning prevents systemic inflammatory response in hemorrhagic shock. Role of HO-1

2002 ◽  
Vol 283 (2) ◽  
pp. G408-G414 ◽  
Author(s):  
Fabienne Tamion ◽  
Vincent Richard ◽  
Yann Lacoume ◽  
Christian Thuillez
Keyword(s):  
Inflammatory Response ◽  
Hemorrhagic Shock ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Systemic Inflammatory Response ◽  
Organ Injury ◽  
Lung Edema ◽  
Heme Oxygenase 1 ◽  
Intestinal Ischemia Reperfusion

Intestinal ischemia-reperfusion has been implicated in the systemic inflammatory response and organ injury in hemorrhagic shock, but the exact role of the intestine has never been directly demonstrated. Preconditioning (PC) with brief periods of intermittent ischemia is a known potent anti-ischemic intervention and thus can be used as a tool to assess the role of local intestinal ischemia-reperfusion injury in systemic inflammatory response. Thus rats were first subjected to sham surgery or intestinal preconditioning with four cycles of 1-min ischemia and 10 min of reperfusion 24 h before hemorrhagic shock followed by resuscitation. PC reduced fluid requirements, lung edema, and lactate and tumor necrosis factor-α production. These effects were abolished by the heme-oxygenase-1 (HO-1) inhibitor tin protoporphyrin (Sn-PP). PC induced more than fivefold in intestinal HO-1 expression. These results suggest that intestinal ischemia-reperfusion is a major trigger for inflammatory response and organ injury in nonseptic shock. HO-1 appears to play an important role in the protective effect of intestinal preconditioning.

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