scholarly journals Reactive oxygen species contribute to simulated ischemia/reperfusion-induced autophagic cell death in human umbilical vein endothelial cells

2014 ◽  
Vol 20 ◽  
pp. 1017-1023 ◽  
Author(s):  
Xiaojun Liu
Keyword(s):  
Reactive Oxygen Species ◽  
Endothelial Cells ◽  
Cell Death ◽  
Umbilical Vein ◽  
Ischemia Reperfusion ◽  
Autophagic Cell Death ◽  
Oxygen Species ◽  
Human Umbilical Vein ◽  
Simulated Ischemia ◽  
Umbilical Vein Endothelial Cells

Effect of flupirtine on cell death of human umbilical vein endothelial cells induced by reactive oxygen species

1998 ◽  
Vol 56 (12) ◽  
pp. 1615-1624 ◽  
Author(s):  
Bernd Lorenz ◽  
Thomas Schlüter ◽  
Ralf Bohnensack ◽  
Gabriela Pergande ◽  
Werner E.G Müller
Keyword(s):  
Reactive Oxygen Species ◽  
Endothelial Cells ◽  
Cell Death ◽  
Umbilical Vein ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells

Effect of prostaglandin E1 on TNF-induced vascular inflammation in human umbilical vein endothelial cells

2010 ◽  
Vol 88 (5) ◽  
pp. 576-583 ◽  
Author(s):  
Wentong Fang ◽  
Hongjian Li ◽  
Liaosheng Zhou ◽  
Lequn Su ◽  
Ying Liang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Endothelial Cells ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Vascular Endothelial Cells ◽  
Umbilical Vein ◽  
Vascular Endothelial ◽  
Oxygen Species ◽  
Human Umbilical Vein ◽  
Umbilical Vein Endothelial Cells

Prostaglandin E1 (PGE1) is a member of the prostaglandins and has a variety of cardiovascular protective effects. Increasing attention has been paid to the anti-inflammation activity of PGE1, but little direct evidence has been found. We investigated the effects of PGE1 on cell adhesion and inflammation and the mechanisms responsible for this activity in tumor necrosis factor (TNF)-treated human umbilical vein endothelial cells. Results demonstrated that pretreatment with PGE1 decreased the adhesion between vascular endothelial cells and monocytes, reduced the expression of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and E-selectin in vascular endothelial cells. In addition, PGE1 suppressed TNF-induced NF-κB activation and production of reactive oxygen species. We concluded that PGE1 suppressed the vascular inflammatory process, which might be closely related to the inhibition of reactive oxygen species and NF-κB activation in human umbilical vein endothelial cells.

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