scholarly journals Novel fibro-inflammation markers in assessing left atrial remodeling in non-valvular atrial fibrillation

2014 ◽  
Vol 20 ◽  
pp. 463-470 ◽  
Author(s):  
Omer Goktekin
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Atrial Remodeling ◽  
Inflammation Markers ◽  
Left Atrial Remodeling

Abstract 18601: Impact of Right and Left Atrial Remodeling on Outcomes From Atrial Fibrillation Rotor Ablation

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Amir Schricker ◽  
Tina Baykaner ◽  
Junaid Zaman ◽  
Gautam Lalani ◽  
Kenneth Hopper ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Structural Changes ◽  
Unknown Etiology ◽  
Atrial Remodeling ◽  
Left Atrial Remodeling ◽  
Single Procedure ◽  
Clinical Indices ◽  
The Right

Introduction: Targets for the ablation of atrial fibrillation (AF) are debated. In particular, recent studies questioning fractionated electrograms and lines has increased focus on AF substrates of rotors and focal impulses. These AF sources are seen in both atria, but have unknown etiology. We hypothesized that differential remodeling between the right atrium (RA), whose structural changes are largely undefined, and left atrium (LA) influence the distribution of AF sources and the outcomes from AF source ablation. Methods: In 60 patients at AF ablation (62±10 years, 60% persistent, 5% long-standing persistent), we compared size differences between RA and LA to the number of sources in each chamber and outcomes from AF source-guide ablation. We studied if a 64-pole basket differentially fit the LA or RA, judged by deformation of its splines by the atria (fig. A, B) over multiple cardiac cycles on fluoroscopy. Ablation targeted sources in both atria and was followed by PVI, with follow-up per guidelines. Results: Using baskets in both atria, 205 sources (LA 138; RA 67) were identified and ablated. Notably, the same basket in each patient was dynamically deformed by RA in 51 (85%) of cases but in the LA in only 39 (65%), indicating greater LA remodeling. The number of AF sources was higher in the presence of basket deformation of RA (n=174) than LA (n=130). LA deformation correlated with LVEF (p=0.05). Freedom from AF at 1 year was reduced in patients with no basket deformation (i.e. dilation) in LA (p=0.07) or RA (p=0.06). Notably, single procedure AF freedom was substantially lower in patients with differential remodeling (deformation in only 1 chamber) of 84% vs. 60% (fig C). Conclusions: Structural atrial remodeling influences the number of electrical rotors and focal sources in each chamber. A mismatch between right and left atrial remodeling predicts lower success from rotor ablation. These data also provide novel clinical indices of effective basket positioning.

scholarly journals Left Atrial Remodeling and Response to Valsartan in the Prevention of Recurrent Atrial Fibrillation

2011 ◽  
Vol 4 (6) ◽  
pp. 721-728 ◽  
Author(s):  
Lidia Staszewsky ◽  
Maylene Wong ◽  
Serge Masson ◽  
Elena Raimondi ◽  
Silvana Gramenzi ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Atrial Remodeling ◽  
Left Atrial Remodeling ◽  
Recurrent Atrial Fibrillation

scholarly journals Reverse Left Atrial Remodeling after Radiofrequency Catheter Ablation for Non-Paroxysmal Atrial Fibrillation

2011 ◽  
Vol 27 (Supplement) ◽  
pp. PE4_028
Author(s):  
Sou Takenaka ◽  
Takashi Nakashima ◽  
Hiroyuki Ozaki ◽  
Mitsuchika Nakamura ◽  
Masato Otsuka ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Catheter Ablation ◽  
Paroxysmal Atrial Fibrillation ◽  
Left Atrial ◽  
Radiofrequency Catheter Ablation ◽  
Atrial Remodeling ◽  
Left Atrial Remodeling
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