scholarly journals A genetic association study of single nucleotide polymorphisms in GNβ3 and COMT in elderly patients with irritable bowel syndrome

2014 ◽  
Vol 20 ◽  
pp. 1246-1254 ◽  
Author(s):  
Yu Zhang
Keyword(s):  
Irritable Bowel Syndrome ◽  
Single Nucleotide Polymorphisms ◽  
Elderly Patients ◽  
Association Study ◽  
Genetic Association ◽  
Genetic Association Study ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Irritable Bowel

scholarly journals Candidate single nucleotide polymorphisms of irritable bowel syndrome: a systemic review and meta-analysis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Shiwei Zhu ◽  
Ben Wang ◽  
Qiong Jia ◽  
Liping Duan
Keyword(s):  
Irritable Bowel Syndrome ◽  
Single Nucleotide Polymorphisms ◽  
Meta Analysis ◽  
Systemic Review ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Genetic Studies ◽  
Increased Risk ◽  
Rome Iii ◽  
Irritable Bowel

Abstract Background Genetic factors increase the risk of irritable bowel syndrome (IBS). Analysis of single nucleotide polymorphisms (SNPs) has been used in IBS patients, but the findings are inconsistent. The goal of this review was to synthesize all the published SNPs studies of IBS through meta-analysis to objectively evaluate the relevance of SNPs to IBS risks. Methods IBS - related polymorphisms studies from 2000 to 2018 were searched. Pooled odds ratios with a 95% confidence interval for each SNP were evaluated through five genetic models. Ethnicity, ROME criteria and IBS subtypes were defined for subgroup analyze. Results Ten relevant genes were evaluated. SNPs rs4263839 and rs6478108 of TNFSF15 associated with an increased risk of IBS; IL6 rs1800795 increased the risk for Caucasian IBS patients which diagnosed by Rome III criteria; and IL23R rs11465804 increased the risk for IBS-C patients. IL10 rs1800896 GG genotype associated with a decreased risk of IBS. No evidence supported the association of GNβ3 rs5443, TNFα rs1800629, and IL10 rs1800871 to IBS in this study. Conclusions This meta-analysis presents an in-depth overview for IBS SNPs analysis. It was confirmed that polymorphisms of TNFSF15 associated with increased IBS risk, while IL10 rs1800896 associated with decreased IBS risk. It might offer some insights into polymorphisms of inflammation factors which might affect IBS susceptibility. Moreover, the analysis also emphasizes the importance of diagnostic criteria and phenotype homogeneity in IBS genetic studies.

A genetic association study of 5-HTT LPR and GN?3 C825T polymorphisms with irritable bowel syndrome

2007 ◽  
Vol 19 (6) ◽  
pp. 465-470 ◽  
Author(s):  
y. a. saito ◽  
g. r. locke ◽  
j. m. zimmerman ◽  
g. holtmann ◽  
j. p. slusser ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Association Study ◽  
Genetic Association ◽  
Genetic Association Study ◽  
Irritable Bowel

scholarly journals Abdominal pain in patients with inflammatory bowel disease: association with single-nucleotide polymorphisms prevalent in irritable bowel syndrome and clinical management

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Martina Ledergerber ◽  
◽  
Brian M. Lang ◽  
Henriette Heinrich ◽  
Luc Biedermann ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Single Nucleotide Polymorphisms ◽  
Bowel Disease ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Inflammatory Bowel ◽  
Irritable Bowel ◽  
The Impact

Abstract Background Abdominal pain is a frequent symptom in patients with inflammatory bowel disease (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC). Pain can result from ongoing inflammation or functional disorders imitating irritable bowel syndrome (IBS). Several single-nucleotide polymorphisms (SNPs) have been associated with IBS. However, the impact of IBS genetics on the clinical course of IBD, especially pain levels of patients remains unclear. Methods Data of 857 UC and 1206 CD patients from the Swiss IBD Cohort Study were analysed. We tested the association of the maximum of the abdominal pain item of disease activity indices in UC and CD over the study period with 16 IBS-associated SNPs, using multivariate ANOVA models. Results In UC patients, the SNPs rs1042713 (located on the ADRB2 gene) and rs4663866 (close to the HES6 gene) were associated with higher abdominal pain levels (P = 0.044; P = 0.037, respectively). Abdominal pain was not associated with any markers of patient management in a model adjusted for confounders. In CD patients, higher levels of abdominal pain correlated with the number of physician contacts (P < 10–15), examinations (P < 10–12), medical therapies (P = 0.023) and weeks of hospitalisation (P = 0.0013) in a multivariate model. Conclusions We detected an association between maximal abdominal pain in UC patients and two IBS-associated SNPs. Abdominal pain levels had a pronounced impact on diagnostic and therapeutic procedures in CD but not in UC patients.

scholarly journals Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251090
Author(s):  
Guangzhi Yang ◽  
Boshen Wang ◽  
Dawei Sun ◽  
Huimin Wang ◽  
Mengyao Chen ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Association Study ◽  
Genetic Association ◽  
Genetic Association Study ◽  
Control Group ◽  
Case Group ◽  
Noise Induced Hearing Loss ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Healthy Control

Noise-induced-hearing-loss(NIHL) is a common occupational disease caused by various environmental and biological factors. To investigate the association between TAB2 and the susceptibility of NIHL of people exposed to occupational environments, a genetic association study was performed on selected companies with 588 cases and 537 healthy control subjects. Five selected single nucleotide polymorphisms (SNPs) in TAB2,incoluding rs2744434, rs521845, rs652921, rs7896, rs9485372, were genotyped after a collection of DNA samples. Evident differences in participants between the case group and the control group reveals the result that people with the TAB2 has a high probability of getting NIHL. The results show that rs521845 is deeply associated with the risk of NIHL and is available for the diagnosis in the future.

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