scholarly journals Application of diffusion tensor imaging (DTI) in pathological changes of the spinal cord

2012 ◽  
Vol 18 (6) ◽  
pp. RA73-RA79 ◽  
Author(s):  
Marek J. Sąsiadek ◽  
Paweł Szewczyk ◽  
Joanna Bladowska
Keyword(s):  
Spinal Cord ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Pathological Changes ◽  
Diffusion Tensor Imaging Dti

scholarly journals Application of multishot diffusion tensor imaging in spinal cord tumors

2019 ◽  
Vol 5 (1) ◽  
pp. 59-64
Author(s):  
Jiefei Li ◽  
Le He ◽  
Yuqi Zhang
Keyword(s):  
Spinal Cord ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Preoperative Imaging ◽  
Spinal Cord Tumors ◽  
Intramedullary Tumors ◽  
Routine Magnetic Resonance Imaging ◽  
Relationship Of ◽  
The Relationship ◽  
Diffusion Tensor Imaging Dti

Objective: To explore the usefulness of multishot diffusion tensor imaging (DTI) for evaluating the neurological function of patients with spinal cord tumors Methods: Routine magnetic resonance imaging and multishot DTI were performed in five patients with spinal cord tumors. The values of fractional anisotropy (FA) and radial diffusivity (RD) were analyzed. Results: Multishot DTI of spinal cord tumors allowed for defining the margins of tumors and determining the relationship of tumors with the adjacent white matter structures of the spinal cord. Multishot DTI demonstrated significantly increased RD and decreased FA of spinal cord tumors compared with those of the normal spinal cord. Conclusions: Multishot DTI is a potentially useful modality for differentiating resectable tumors from nonresectable ones based on preoperative imaging alone as well as for differentiating intramedullary tumors from extramedullary ones. Further prospective studies are warranted to confirm these results.

scholarly journals Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Xiaoyun Xu ◽  
Matthew Cowan ◽  
Flavio Beraldo ◽  
Amy Schranz ◽  
Patrick McCunn ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Diffusion Tensor ◽  
Diffuse Axonal Injury ◽  
Synaptic Proteins ◽  
Resonance Spectroscopy ◽  
Pathological Changes ◽  
Diffusion Tensor Imaging Dti

AbstractWe have previously reported long-term changes in the brains of non-concussed varsity rugby players using magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI) and functional magnetic imaging (fMRI). Others have reported cognitive deficits in contact sport athletes that have not met the diagnostic criteria for concussion. These results suggest that repetitive mild traumatic brain injuries (rmTBIs) that are not severe enough to meet the diagnostic threshold for concussion, produce long-term consequences. We sought to characterize the neuroimaging, cognitive, pathological and metabolomic changes in a mouse model of rmTBI. Using a closed-skull model of mTBI that when scaled to human leads to rotational and linear accelerations far below what has been reported for sports concussion athletes, we found that 5 daily mTBIs triggered two temporally distinct types of pathological changes. First, during the first days and weeks after injury, the rmTBI produced diffuse axonal injury, a transient inflammatory response and changes in diffusion tensor imaging (DTI) that resolved with time. Second, the rmTBI led to pathological changes that were evident months after the injury including: changes in magnetic resonance spectroscopy (MRS), altered levels of synaptic proteins, behavioural deficits in attention and spatial memory, accumulations of pathologically phosphorylated tau, altered blood metabolomic profiles and white matter ultrastructural abnormalities. These results indicate that exceedingly mild rmTBI, in mice, triggers processes with pathological consequences observable months after the initial injury.

Diffusion tensor imaging (DTI) and Tractography of the spinal cord in pediatric population with spinal lipomas: preliminary study

2018 ◽  
Vol 35 (1) ◽  
pp. 129-137 ◽  
Author(s):  
Pierre Antherieu ◽  
R. Levy ◽  
T. De Saint Denis ◽  
L. Lohkamp ◽  
G. Paternoster ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Pediatric Population ◽  
Preliminary Study ◽  
Diffusion Tensor Imaging Dti

scholarly journals Diffusion tensor imaging of the spinal cord: a review

2013 ◽  
Vol 12 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Aditya Vedantam ◽  
Michael Jirjis ◽  
Gerald Eckhardt ◽  
Abhishiek Sharma ◽  
Brian D. Schmit ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Diffusion Tensor Imaging ◽  
Cervical Spondylotic Myelopathy ◽  
Diffusion Tensor ◽  
Traumatic Spinal Cord Injury ◽  
Intramedullary Tumors ◽  
Cord Injury ◽  
Magnetic Resonance Technique ◽  
Spinal Cord Disorders ◽  
Diffusion Tensor Imaging Dti

Diffusion tensor imaging (DTI) is a magnetic resonance technique capable of measuring the magnitude and direction of water molecule diffusion in various tissues. The use of DTI is being expanded to evaluate a variety of spinal cord disorders both for prognostication and to guide therapy. The purpose of this article is to review the literature on spinal cord DTI in both animal models and humans in different neurosurgical conditions. DTI of the spinal cord shows promise in traumatic spinal cord injury, cervical spondylotic myelopathy, and intramedullary tumors. However, scanning protocols and image processing need to be refined and standardized.

scholarly journals THE ROLE OF DIFFUSION TENSOR IMAGING (DTI) IN SPINAL CORD PATHOLOGY

2020 ◽  
Vol 71 (1) ◽  
pp. 197-205
Author(s):  
Hend Hassan ◽  
Rania Maarouf ◽  
Mohamed Abo-Elela ◽  
Norhan Mohamady
Keyword(s):  
Spinal Cord ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Diffusion Tensor Imaging Dti

scholarly journals Diffusion Tensor Imaging of the Spinal Cord

Neurosurgery ◽  
2013 ◽  
Vol 74 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Aditya Vedantam ◽  
Michael B. Jirjis ◽  
Brian D. Schmit ◽  
Marjorie C. Wang ◽  
John L. Ulmer ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Cord Compression ◽  
Directional Diffusion ◽  
Neural Damage ◽  
Cord Injury ◽  
Spinal Cord Disorders ◽  
Diffusion Tensor Imaging Dti

Abstract Diffusion tensor imaging (DTI) provides a measure of the directional diffusion of water molecules in tissues. The measurement of DTI indexes within the spinal cord provides a quantitative assessment of neural damage in various spinal cord pathologies. DTI studies in animal models of spinal cord injury indicate that DTI is a reliable imaging technique with important histological and functional correlates. These studies demonstrate that DTI is a noninvasive marker of microstructural change within the spinal cord. In human studies, spinal cord DTI shows definite changes in subjects with acute and chronic spinal cord injury, as well as cervical spondylotic myelopathy. Interestingly, changes in DTI indexes are visualized in regions of the cord, which appear normal on conventional magnetic resonance imaging and are remote from the site of cord compression. Spinal cord DTI provides data that can help us understand underlying microstructural changes within the cord and assist in prognostication and planning of therapies. In this article, we review the use of DTI to investigate spinal cord pathology in animals and humans and describe advances in this technique that establish DTI as a promising biomarker for spinal cord disorders.

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