scholarly journals Radiation dose effect of DNA repair-related gene expression in mouse white blood cells

2011 ◽  
Vol 17 (10) ◽  
pp. BR290-BR297 ◽  
Author(s):  
Ming-juan Li ◽  
Wei-wei Wang ◽  
Shi-wei Chen ◽  
Qian Shen ◽  
Rui Min
Keyword(s):  
Gene Expression ◽  
Dna Repair ◽  
Radiation Dose ◽  
Blood Cells ◽  
White Blood Cells ◽  
Dose Effect ◽  
Related Gene

Gene Expression Differences in White Blood Cells after Escherichia coli Infection in Chickens

2012 ◽  
Author(s):  
Erin Sandford ◽  
Megan Orr ◽  
Xianyao Li ◽  
Huaijun Zhou ◽  
timothy J. Johnson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Escherichia Coli ◽  
Blood Cells ◽  
White Blood Cells ◽  
Escherichia Coli Infection

scholarly journals Gene expression of the heat stress response in bovine peripheral white blood cells and milk somatic cells in vivo

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
J. B. Garner ◽  
A. J. Chamberlain ◽  
C. Vander Jagt ◽  
T. T. T. Nguyen ◽  
B. A. Mason ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heat Stress ◽  
Blood Cells ◽  
White Blood Cells ◽  
Somatic Cells ◽  
Holstein Friesian ◽  
Milk Somatic Cells ◽  
Peripheral White Blood Cells ◽  
Friesian Cows

Abstract Heat stress in dairy cattle leads to reduction in feed intake and milk production as well as the induction of many physiological stress responses. The genes implicated in the response to heat stress in vivo are not well characterised. With the aim of identifying such genes, an experiment was conducted to perform differential gene expression in peripheral white blood cells and milk somatic cells in vivo in 6 Holstein Friesian cows in thermoneutral conditions and in 6 Holstein Friesian cows exposed to a short-term moderate heat challenge. RNA sequences from peripheral white blood cells and milk somatic cells were used to quantify full transcriptome gene expression. Genes commonly differentially expressed (DE) in both the peripheral white blood cells and in milk somatic cells were associated with the cellular stress response, apoptosis, oxidative stress and glucose metabolism. Genes DE in peripheral white blood cells of cows exposed to the heat challenge compared to the thermoneutral control were related to inflammation, lipid metabolism, carbohydrate metabolism and the cardiovascular system. Genes DE in milk somatic cells compared to the thermoneutral control were involved in the response to stress, thermoregulation and vasodilation. These findings provide new insights into the cellular adaptations induced during the response to short term moderate heat stress in dairy cattle and identify potential candidate genes (BDKRB1 and SNORA19) for future research.

scholarly journals Effects of copy number variable regions on local gene expression in white blood cells of Mexican Americans

2015 ◽  
Vol 23 (9) ◽  
pp. 1229-1235 ◽  
Author(s):  
August Blackburn ◽  
Marcio Almeida ◽  
Angela Dean ◽  
Joanne E Curran ◽  
Matthew P Johnson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Blood Cells ◽  
Mexican Americans ◽  
Copy Number ◽  
White Blood Cells ◽  
Variable Regions

scholarly journals Rewiring of gene expression in circulating white blood cells is associated with pregnancy outcome in heifers (Bos taurus)

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Sarah E. Moorey ◽  
Bailey N. Walker ◽  
Michelle F. Elmore ◽  
Joshua B. Elmore ◽  
Soren P. Rodning ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pregnancy Outcome ◽  
Artificial Insemination ◽  
Blood Cells ◽  
Expression Profiles ◽  
White Blood Cells ◽  
Transcript Abundance ◽  
Prediction Algorithm ◽  
Differential Coexpression ◽  
Micro Rnas

Abstract Infertility is a challenging phenomenon in cattle that reduces the sustainability of beef production worldwide. Here, we tested the hypothesis that gene expression profiles of protein-coding genes expressed in peripheral white blood cells (PWBCs), and circulating micro RNAs in plasma, are associated with female fertility, measured by pregnancy outcome. We drew blood samples from 17 heifers on the day of artificial insemination and analyzed transcript abundance for 10,496 genes in PWBCs and 290 circulating micro RNAs. The females were later classified as pregnant to artificial insemination, pregnant to natural breeding or not pregnant. We identified 1860 genes producing significant differential coexpression (eFDR < 0.002) based on pregnancy outcome. Additionally, 237 micro RNAs and 2274 genes in PWBCs presented differential coexpression based on pregnancy outcome. Furthermore, using a machine learning prediction algorithm we detected a subset of genes whose abundance could be used for blind categorization of pregnancy outcome. Our results provide strong evidence that transcript abundance in circulating white blood cells is associated with fertility in heifers.

scholarly journals No acute impact of haemodialysis treatment on free radical scavenging enzyme gene expression in white blood cells

2003 ◽  
Vol 253 (2) ◽  
pp. 201-207 ◽  
Author(s):  
V. Schettler ◽  
W. Kuhn ◽  
T. Kleinoeder ◽  
V. W. Armstrong ◽  
M. Oellerich ◽  
...  
Keyword(s):  
Gene Expression ◽  
Free Radical ◽  
Blood Cells ◽  
White Blood Cells ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Enzyme Gene ◽  
Haemodialysis Treatment
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