scholarly journals Impact of Preoperative Abdominal Visceral Adipose Tissue Area and Nutritional Status on Renal Function After Donor Nephrectomy in Japanese Living Donors for Renal Transplantation

2018 ◽  
Vol 23 ◽  
pp. 364-376 ◽  
Author(s):  
Shunta Hori ◽  
Makito Miyake ◽  
Yosuke Morizawa ◽  
Yasushi Nakai ◽  
Kenta Onishi ◽  
...  
Keyword(s):  
Renal Function ◽  
Adipose Tissue ◽  
Renal Transplantation ◽  
Nutritional Status ◽  
Visceral Adipose Tissue ◽  
Living Donors ◽  
Donor Nephrectomy ◽  
Tissue Area ◽  
Visceral Adipose

scholarly journals LBA17 DONOR VISCERAL ADIPOSE TISSUE BETTER PREDICTOR OF LONG-TERM RENAL FUNCTION DECLINE THAN BODY MASS INDEX

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Karen Stern ◽  
Sherif Armanyous ◽  
Erick Remer ◽  
Ryan Ward ◽  
Joshua Augustine ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Renal Function ◽  
Adipose Tissue ◽  
Body Mass ◽  
Visceral Adipose Tissue ◽  
Renal Function Decline ◽  
Visceral Adipose

Circulating 5α-dihydrotestosterone, abdominal obesity and adipocyte characteristics in women

2012 ◽  
Vol 12 (2) ◽  
Author(s):  
Julie A. Côté ◽  
Julie Lessard ◽  
Jacques Mailloux ◽  
Philippe Laberge ◽  
Caroline Rhéaume ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Adipose Tissue ◽  
Body Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Visceral Adipose Tissue ◽  
Fat Distribution ◽  
Tissue Area ◽  
Visceral Adipose ◽  
Androgen Levels

AbstractThe association between circulating androgen levels and fat distribution in women has been widely inconsistent among existing studies.We sought to investigate the relation between plasma adrenal and gonadal androgen levels and body fat distribution, as well as abdominal adipocyte characteristics.Paired omental and subcutaneous adipose tissue samples were surgically obtained from 60 women (age, 47±5 years; body mass index, 26±5 kg/mSignificant negative associations were found between plasma dihydrotestosterone (DHT) levels and total adiposity (body mass index, r=–0.35, p<0.05; fat mass, r=–0.31, p<0.05) as well as computed tomography assessments of abdominal adiposity (r=–0.30, p<0.05 and r=–0.44, p<0.005 for subcutaneous and visceral adipose tissue area, respectively). The association between DHT levels and visceral adipose tissue area was independent of total body fat mass. A significant negative association was also observed between plasma DHT and omental adipocyte diameter (r=–0.27, p<0.05). When expressed as the omental/subcutaneous ratio, heparin-releasable lipoprotein lipase activity was negatively and significantly related to plasma DHT, androstenedione, and dehydroepiandrosterone (DHEA) levels.Abdominally obese women with large, metabolically active omental adipocytes appear to be characterized by reduced endogenous levels of DHT. The assumption that high androgen levels are associated with an android body fat distribution pattern in women should be critically re-examined.

Is post-transplant metabolic syndrome associated with pre-liver transplant visceral adipose tissue area?

2020 ◽  
Vol 39 ◽  
pp. 61-66
Author(s):  
Aidan J. Woodward ◽  
Matthew P. Wallen ◽  
John Ryan ◽  
Adrian Hall ◽  
Leigh C. Ward ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Liver Transplant ◽  
Visceral Adipose Tissue ◽  
Post Transplant ◽  
Tissue Area ◽  
Visceral Adipose

scholarly journals Visceral adipose tissue area predicts intensive care unit admission in COVID-19 patients

2020 ◽  
Author(s):  
Federica Pediconi ◽  
Veronica Rizzo ◽  
Simone Schiaffino ◽  
Andrea Cozzi ◽  
Gianmarco Della Pepa ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Adipose Tissue ◽  
Intensive Care ◽  
Intensive Care Unit Admission ◽  
Visceral Adipose Tissue ◽  
Tissue Area ◽  
Visceral Adipose

scholarly journals CT-based determination of excessive visceral adipose tissue is associated with an impaired survival in critically ill patients

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250321
Author(s):  
Theresa H. Wirtz ◽  
Sven H. Loosen ◽  
Maximilian Schulze-Hagen ◽  
Ralf Weiskirchen ◽  
Lukas Buendgens ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Adipose Tissue ◽  
Tissue Distribution ◽  
Visceral Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Short Term ◽  
Adipose Tissue Distribution ◽  
Tissue Area ◽  
Visceral Adipose ◽  
Subcutaneous Adipose

Objective Obesity is a negative prognostic factor for various clinical conditions. In this observational cohort study, we evaluated a CT-based assessment of the adipose tissue distribution as a potential non-invasive prognostic parameter in critical illness. Methods Routine CT-scans upon admission to the intensive care unit (ICU) were used to analyze the visceral and subcutaneous adipose tissue areas at the 3rd lumbar vertebra in 155 patients. Results were correlated with various prognostic markers and both short-term- and overall survival. Multiple statistical tools were used for data analysis. Results We observed a significantly larger visceral adipose tissue area in septic patients compared to non-sepsis patients. Interestingly, patients requiring mechanical ventilation had a significantly higher amount of visceral adipose tissue correlating with the duration of mechanical ventilation. Moreover, both visceral and subcutaneous adipose tissue area significantly correlated with several laboratory markers. While neither the visceral nor the subcutaneous adipose tissue area was predictive for short-term ICU survival, patients with a visceral adipose tissue area above the optimal cut-off (241.4 cm2) had a significantly impaired overall survival compared to patients with a lower visceral adipose tissue area. Conclusions Our study supports a prognostic role of the individual adipose tissue distribution in critically ill patients. However, additional investigations need to confirm our suggestion that routine CT-based assessment of adipose tissue distribution can be used to yield further information on the patients’ clinical course. Moreover, future studies should address functional and metabolic analysis of different adipose tissue compartments in critical illness.

scholarly journals Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk

2015 ◽  
Vol 309 (8) ◽  
pp. E736-E746 ◽  
Author(s):  
Marie Michèle Boulet ◽  
Geneviève Chevrier ◽  
Thomas Grenier-Larouche ◽  
Mélissa Pelletier ◽  
Mélanie Nadeau ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Gynecologic Surgery ◽  
Obese Women ◽  
Protein Levels ◽  
Tissue Area ◽  
Visceral Adipose

Metabolomic profiling of obese individuals revealed altered concentrations of many metabolites, especially branched-chain amino acids (BCAA), possibly linked to altered adipose tissue BCAA catabolism. We tested the hypothesis that some features of this metabolite signature relate closely to visceral obesity and concomitant alterations in cardiometabolic risk factors. We also postulated that alterations in BCAA-catabolizing enzymes are predominant in visceral adipose tissue. Fifty-nine women (BMI 20–41 kg/m2) undergoing gynecologic surgery were recruited and characterized for overall and regional adiposity, blood metabolite levels using targeted metabolomics, and cardiometabolic risk factors. Adipose samples (visceral and subcutaneous) were obtained and used for gene expression and Western blot analyses. Obese women had significantly higher circulating BCAA and kynurenine/tryptophan (Kyn/Trp) ratio than lean or overweight women ( P < 0.01). Principal component analysis confirmed that factors related to AA and the Kyn/Trp ratio were positively associated with BMI, fat mass, visceral or subcutaneous adipose tissue area, and subcutaneous adipocyte size ( P ≤ 0.05). AA-related factor was positively associated with HOMA-IR ( P ≤ 0.01). Factors reflecting glycerophospholipids and sphingolipids levels were mostly associated with altered blood lipid concentrations ( P ≤ 0.05). Glutamate level was the strongest independent predictor of visceral adipose tissue area ( r = 0.46, P < 0.001). Obese women had lower expression and protein levels of BCAA-catabolizing enzymes in visceral adipose tissue than overweight or lean women ( P ≤ 0.05). We conclude that among metabolites altered in obesity plasma concentrations of BCAA and the Kyn/Trp ratio are closely related to increased adiposity. Alterations in expression and protein levels of BCAA-catabolizing enzymes are predominant in visceral adipose tissue.

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