scholarly journals Clinical Features, Treatment and Prognostic Factors of Post-Transplant Immunoglobulin A Nephropathy

2018 ◽  
Vol 23 ◽  
pp. 166-175 ◽  
Author(s):  
Diogo Buarque Cordeiro Cabral ◽  
Tainá Veras de Sandes-Freitas ◽  
José Osmar Medina-Pestana ◽  
Gianna Mastroianni-Kirsztajn
Keyword(s):  
Prognostic Factors ◽  
Clinical Features ◽  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy ◽  
Post Transplant

scholarly journals Prognostic factors for renal allograft survival in patients with immunoglobulin A nephropathy: A case control study

2014 ◽  
Vol 9 (4) ◽  
pp. 1179-1184 ◽  
Author(s):  
JUN-QI GUO ◽  
BAO-LIN SONG ◽  
ZHI-XIAN WU ◽  
WEI-ZHEN WU ◽  
LIU-TAO LUO ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Renal Allograft ◽  
Case Control Study ◽  
Immunoglobulin A ◽  
Case Control ◽  
Immunoglobulin A Nephropathy ◽  
Allograft Survival ◽  
Control Study

Evaluating the Clinical Course and Prognostic Factors of Posttransplantation Immunoglobulin A Nephropathy

2008 ◽  
Vol 40 (7) ◽  
pp. 2349-2354 ◽  
Author(s):  
K. Kiattisunthorn ◽  
N. Premasathian ◽  
A. Wongwiwatana ◽  
P. Parichatikanond ◽  
B. Cheunsuchon ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Clinical Course ◽  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy

scholarly journals Immunoglobulin A nephropathy: Basic characteristics

2003 ◽  
Vol 56 (5-6) ◽  
pp. 281-285
Author(s):  
Lada Petrovic ◽  
Slobodan Curic ◽  
Igor Mitic ◽  
Dusan Bozic ◽  
Slavenka Vodopivec ◽  
...  
Keyword(s):  
Light Microscopy ◽  
Renal Biopsy ◽  
Clinical Features ◽  
Serological Test ◽  
Immunoglobulin A ◽  
Vascular Lesions ◽  
Immunoglobulin A Nephropathy ◽  
Macroscopic Hematuria ◽  
Female Ratio ◽  
Pathologic Features

Introduction Immunoglobulin A nephropathy (IgAN) is one of the most common forms of primary glomerulonephritis in many countries. Most clinical features of IgAN point to a renal problem, such as recurrent macroscopic hematuria or asymptomatic microscopic hematuria and proteinuria. Pathologic features of IgAN present with different types and different degrees of glomerular tubulointerstitial and vascular lesions. The aim of this study was detailed analysis of clinical and laboratory findings, as well as findings of immunofluorescence and light microscopy. We also investigated associations between these factors. Material and methods We investigated 60 patients who underwent renal biopsy. The study was partly retrospective and partly prospective. Results The average age of patients was 34.19 years. Male female ratio was 2.33:1. IgAN was most frequently asymptomatic (83.33%) as microhematuria and proteinuria, while gross hematuria was found in 16.667%. Renal biopsy material was analyzed by light microscopy revealing changes in all glomerular structures. Immunofluorescence microscopy demonstrated dominant IgA deposits. This study established association of glomerulosclerosis with clinical features of disease. Discussion and conclusions IgAN frequently develops in the 4th decade of life, mostly in males and presents as asymptomatic (83.33%). Patohistological changes include all glomerular structures. There is no specific serological test for IgAN, but pathological changes affect clinical features of the disease, as proteinuria and increase of creatinine concentration.

scholarly journals Immunoglobulin A nephropathy and its prognostic factors

2002 ◽  
Vol 55 (11-12) ◽  
pp. 517-522
Author(s):  
Lada Petrovic ◽  
Slobodan Curic ◽  
Igor Mitic ◽  
Dusan Bozic ◽  
Slavenka Vodopivec ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Renal Biopsy ◽  
Clinical Features ◽  
Normal Renal Function ◽  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy ◽  
Laboratory Findings ◽  
Heavy Proteinuria ◽  
The Moment

Introduction Immunoglobulin A nephropathy (IgAN) is a clinicopathological entity characterized by diffuse glomerular mesangial deposition of IgA as the predominant immunoglobulin. Renal biopsy reveals a spectrum of changes in glomerula, tubulointerstitium and blood vessels. 20-50% of all patients develop end-stage renal failure 20 years after onset of disease. The aim of this study was to investigate the incidence of IgAN and to analyze clinicopathological changes and prognosis of IgAN. Material and methods The study included 60 patients with biopsy-proved IgAN without some other systemic diseases or Henoch-Schonlen purpura. We analyzed clinical features of the disease, laboratory findings, findings of immunofluorescence and light microscopy and prognosis of IgAN. The study is partly retrospective and partly prospective. Results and discussion Incidence of the disease in the period 1981-1997 was 9.78%. At the moment of renal biopsy 63.16% of patients had normal renal function, 31.58% had stage I and 5.25% had stage II chronic renal failure. At the end of study 21.05% of investigated patients were included into the worse stage of renal failure in regard to the initial stage. Progression of renal damage correlated with special tubulointerstitial damage and heavy proteinuria. Conclusions In this study we found severe histopathological changes in the group with already impaired renal function and these changes correlated with laboratory findings, clinical features and prognosis. Normal renal function at the moment of renal biopsy pointed to risk for further damage. Changes in the tubulointerstitium and mesangium, heavy proteinuria and hypertension affect the disease prognosis. Evolution to the higher stage of renal failure was 1.24% per year and this requires long-term follow-up of patients with IgAN.

scholarly journals Effect of steroid pulse therapy on post-transplant immunoglobulin A nephropathy

Nephrology ◽  
2018 ◽  
Vol 23 ◽  
pp. 10-16 ◽  
Author(s):  
Yuta Matsukuma ◽  
Kosuke Masutani ◽  
Akihiro Tsuchimoto ◽  
Yasuhiro Okabe ◽  
Masafumi Nakamura ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Pulse Therapy ◽  
Steroid Pulse Therapy ◽  
Immunoglobulin A Nephropathy ◽  
Steroid Pulse ◽  
Post Transplant

Utility of Oxford Classification in Post-Transplant Immunoglobulin A Nephropathy

2017 ◽  
Vol 49 (10) ◽  
pp. 2274-2279
Author(s):  
V. Agrawal ◽  
A. Singh ◽  
A. Kaul ◽  
R. Verma ◽  
M. Jain ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy ◽  
Oxford Classification ◽  
Post Transplant

Plasma CXCL16 May Predict Renal Inflammation and the Progression of Immunoglobulin a Nephropathy

2019 ◽  
Author(s):  
Ran Luo ◽  
Yi-Chun Chen ◽  
Dan Chang ◽  
Ting-Ting Liu ◽  
Yue-Qiang Li ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy ◽  
Renal Inflammation

Evaluation of Clinical Profile, Diagnostic Tests, And Prognosis of Cryptococcal Meningitis in HIV Infected Patients in Western India

2020 ◽  
Vol 20 ◽  
Author(s):  
Deepak Kumar ◽  
Suresh Bishnoi ◽  
Durga Shankar Meena ◽  
Gopal Krishana Bohra ◽  
Naresh Midha ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Clinical Features ◽  
Cryptococcal Meningitis ◽  
Fatal Outcome ◽  
Clinical Profile ◽  
Western India ◽  
Antigen Test ◽  
Cryptococcal Antigen ◽  
India Ink ◽  
Csf Examination

Background: Cryptococcal meningitis is a dreaded complication in HIV infected patients. It was associated with high mortality and morbidity before the advent of Highly Active Anti-Retroviral Therapy. A study was planned in our institute to evaluate the clinical profile, laboratory findings, and prognostic factors for survival in these patients. Settings and Design: A prospective hospital-based observational study, conducted in the Department of Medicine at a tertiary care centre in western Rajasthan. Method and Material: HIV infected patients presenting with clinical features of meningitis, and positive CSF culture for Cryptococcus were included in our study. All cases underwent detailed clinical history, physical examinations and relevant laboratory investigations including CD4 count and CSF examination. Results: 48 HIV infected cryptococcal meningitis patients were analysed, and the most common presenting clinical features were headache (85.42%), and fever (72.92%), followed by neck stiffness (62.50%). CSF examination was also done for Cryptococcal Antigen test which was reactive in all cases (100%), and India ink staining was positive in 43 cases (89.58%). Significant fatal outcome was associated with patients presenting with altered sensorium, loss of consciousness, cranial nerve palsy and CD4 cell count of less than 100. Similarly, on laboratory and imaging diagnosis, cryptococcal antigen test (>3+reactive), fundus examination (papilloedema) and abnormal CT/MRI brain imaging were associated with poor survival. Conclusion: Cryptococcal meningitis is a potentially lethal infection in immunocompromised individuals and should be diagnosed early with high clinical suspicion as around 10% of the cases may not be detected on India ink staining and a large proportion (75%) of cases may have normal imaging at initial evaluation. Early diagnosis, watchful eye on prognostic factors and treatment is vital to improve outcome in these patients.

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