De Novo Renal Neoplasia After Kidney Transplantation According to New 2016 WHO Classification of Renal Tumors

The ISUP system of staging, grading and classification of renal cell neoplasia

Journal of Kidney Cancer and VHL ◽

10.15586/jkcvhl.2014.11 ◽

2014 ◽

Vol 1 (3) ◽

pp. 26-39 ◽

Cited By ~ 18

Author(s):

Hemamali Samaratunga ◽

Troy Gianduzzo ◽

Brett Delahunt

Keyword(s):

Renal Cell ◽

Who Classification ◽

Majority Vote ◽

Cell Cancer ◽

Consensus Conference ◽

World Health ◽

Renal Tumors ◽

International Consensus ◽

Staging Classification

There have been significant changes in the staging, classification and grading of renal cell neoplasia in recent times. Major changes have occurred in our understanding of extra-renal extension by renal cell cancer and how gross specimens must be handled to optimally display extra-renal spread. Since the 1981 World Health Organization (WHO) classification of renal tumors, in which only a handful of different entities were reported, many new morphological types have been described in the literature, resulting in 50 different entities reported in the 2004 WHO classification. Since 2004, further new entities have been recognized and reported necessitating an update of the renal tumor classification. There have also been numerous grading systems for renal cell carcinoma with Fuhrman grading, the most widely used system. In recent times, the prognostic value and the applicability of the Fuhrman grading system in practice has been shown to be, at best, suboptimal. To address these issues and to recommend reporting guidelines, the International Society of Urological Pathology (ISUP) undertook a review of adult renal neoplasia through an international consensus conference in Vancouver in 2012. The conduct of the conference was based upon evidence from the literature and the current practice amongst recognized experts in the field. Working groups selected to deal with key topics evaluated current data and identified points of controversy. A pre-meeting survey of the ISUP membership was followed by the consensus conference at which a formal ballot was taken on each key issue. A 65% majority vote was taken as consensus. This review summarizes the outcome and recommendations of this conference with regards to staging, classification and grading of renal cell neoplasia.

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The 2016 revision of the WHO classification of tumours of the central nervous system

10.1093/med/9780199651870.003.0001 ◽

2017 ◽

Author(s):

Paul Kleihues ◽

Elisabeth Rushing ◽

Hiroko Ohgaki

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Who Classification ◽

De Novo ◽

Genetic Profiling ◽

Primary Glioblastoma ◽

System P ◽

Significant Step ◽

The Central Nervous System

The revised fourth edition of the WHO classification of Tumours of the Central Nervous System, published in 2016, comprises several newly recognized tumour entities, and a significant restructuring of the classification, mainly based on genetic profiling. Glioblastomas are now classified into two major types. Isocitrate dehydrogenase (IDH)-wildtype glioblastoma (primary glioblastoma IDH-wildtype) develops rapidly de novo without a recognizable precursor lesion. IDH-mutant glioblastoma (secondary glioblastoma IDH-mutant) develops more slowly through malignant progression from diffuse or anaplastic astrocytoma. Medulloblastomas are now defined by combining histological patterns (classic, desmoplastic/nodular, extensive nodularity, anaplastic) and genetic hallmarks (WNT-activated; SHH-activated, TP53-mutant; SHH-activated, TP53-wildtype; non-WNT/non-SHH). Other newly recognized tumour entities include diffuse midline glioma, H3 K27M-mutant; ependymoma, RELA fusion-positive; and embryonal tumour with multilayered rosettes. The new classification is a significant step forward and will facilitate the development of novel targeted therapies of brain tumours.

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The 2012 ISUP Vancouver and 2016 WHO classification of adult renal tumors: changes for common renal tumors

Diagnostic Histopathology ◽

10.1016/j.mpdhp.2016.01.003 ◽

2016 ◽

Vol 22 (2) ◽

pp. 41-46 ◽

Cited By ~ 5

Author(s):

Ondřej Hes ◽

Eva Maria Compérat ◽

Nathalia Rioux-Leclercq ◽

Naoto Kuroda

Keyword(s):

Who Classification ◽

Renal Tumors

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Classification of renal cell tumors – current concepts and use of ancillary tests: recommendations of the Brazilian Society of Pathology

Surgical and Experimental Pathology ◽

10.1186/s42047-020-00084-x ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Daniel Abensur Athanazio ◽

Luciana Schultz Amorim ◽

Isabela Werneck da Cunha ◽

Katia Ramos Moreira Leite ◽

Alexandre Rolim da Paz ◽

...

Keyword(s):

Renal Cell ◽

Who Classification ◽

Recent Literature ◽

Underlying Disease ◽

Genetic Alterations ◽

Renal Tumors ◽

Specific Gene ◽

Brazilian Society ◽

Resource Limited

AbstractClassification of renal cell carcinomas has become more challenging. The 2016 WHO classification included 14 different subtypes and 4 emerging/provisional entities, and recent literature indicates new entities to be incorporated. Nomenclature is based on cytoplasmic appearance, architecture, combination of morphologies, anatomic location, underlying disease, familial syndromes, and specific genetic alterations. Immunohistochemistry is useful in selected cases while it can be insufficient in entities that require molecular confirmation of a specific gene alteration. The aim of these recommendations is to provide a reasonable and optimized approach for the use of ancillary tests in subtyping renal tumors, particularly in resource-limited settings.

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ESC, ALK, HOT and LOT: Three Letter Acronyms of Emerging Renal Entities Knocking on the Door of the WHO Classification

Cancers ◽

10.3390/cancers12010168 ◽

2020 ◽

Vol 12 (1) ◽

pp. 168 ◽

Cited By ~ 7

Author(s):

Farshid Siadat ◽

Kiril Trpkov

Keyword(s):

Renal Cell ◽

Who Classification ◽

Renal Tumor ◽

Current Knowledge ◽

World Health ◽

Renal Tumors ◽

Low Grade ◽

Kidney Tumors ◽

Anaplastic Lymphoma

Kidney neoplasms are among the most heterogeneous and diverse tumors. Continuous advancement of this field is reflected in the emergence of new tumour entities and an increased recognition of the expanding morphologic, immunohistochemical, molecular, epidemiologic and clinical spectrum of renal tumors. Most recent advances after the 2016 World Health Organization (WHO) classification of renal cell tumors have provided new evidence on some emerging entities, such as anaplastic lymphoma kinase rearrangement-associated RCC (ALK-RCC), which has already been included in the WHO 2016 classification as a provisional entity. Additionally, several previously unrecognized entities, not currently included in the WHO classification, have also been introduced, such as eosinophilic solid and cystic renal cell carcinoma (ESC RCC), low-grade oncocytic renal tumor (LOT) and high-grade oncocytic renal tumor (HOT) of kidney. Although pathologists play a crucial role in the recognition and classification of these new tumor entities and are at the forefront of the efforts to characterize them, the awareness and the acceptance of these entities among clinicians will ultimately translate into more nuanced management and improved prognostication for individual patients. In this review, we summarise the current knowledge and the novel data on these emerging renal entities, with an aim to promote their increased diagnostic recognition and better characterization, and to facilitate further studies that will hopefully lead to their formal recognition and consideration in the future classifications of kidney tumors.

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