scholarly journals Anaplastic Transformation of Differentiated Papillary Thyroid Carcinoma Presenting as Cauda Equina Syndrome

2021 ◽  
Vol 22 ◽  
Author(s):  
Jennifer M. van Griethuysen ◽  
Ian Proctor ◽  
Suganya Sivabalasingham
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Cauda Equina Syndrome ◽  
Cauda Equina ◽  
Papillary Thyroid ◽  
Anaplastic Transformation

scholarly journals Squamous Cell Carcinoma of the Thyroid as a Result of Anaplastic Transformation from BRAF-Positive Papillary Thyroid Cancer

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Alina Basnet ◽  
Aakriti Pandita ◽  
Joseph Fullmer ◽  
Abirami Sivapiragasam
Keyword(s):  
Squamous Cell Carcinoma ◽  
Thyroid Cancer ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Cell Carcinoma ◽  
Papillary Thyroid Cancer ◽  
Squamous Cell ◽  
Malignant Neoplasm ◽  
Papillary Thyroid ◽  
Anaplastic Transformation

Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of the thyroid. Majority of the PTC carries an excellent prognosis. However, patients with tall cell variant (TCV) of papillary thyroid carcinoma have a worse prognosis than those with the classic variant. On the other hand, squamous cell carcinoma of the thyroid (SCT) is an unusual neoplasm thought to arise as a primary tumor or as a component of an anaplastic or undifferentiated carcinoma. We report a patient with TCV of PTC presenting years later with squamous transformation. In addition, the patient was found to have BRAF mutation. Such dedifferentiation is considered to be a rare phenomenon and has been reported only in the form of case reports in the literature. The relationship between BRAFV600E mutation and squamous cell transformation of papillary thyroid cancer is unknown at this time. Meticulous pathology is needed to identify such variants. Our patient responded to treatment with concurrent chemotherapy with carboplatin and paclitaxel along with radiation.

scholarly journals Occult multifocal papillary thyroid carcinoma presenting as anaplastic carcinoma in the metastatic neck deposit – A rare case report along with review of literature

2021 ◽  
Vol 6 (3) ◽  
pp. 216-222
Author(s):  
Arti R Anvikar ◽  
Yasmin A. Momin ◽  
Jaydeep N. Pol ◽  
Alka V Gosavi
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
World Literature ◽  
Transformation Process ◽  
Anaplastic Carcinoma ◽  
Small Subset ◽  
Papillary Thyroid ◽  
First Case ◽  
Anaplastic Transformation ◽  
Rare Case Report

Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma that carries a favourable prognosis. However, a small subset unfortunately shows transformation to least differentiated anaplastic carcinoma (AC) having a highly aggressive behavior. This process usually occurs within thyroid but is rare in metastatic cervical lymph node or soft tissue neck and exceedingly rare at distant sites. We report a unique case of a 75 years female who presented with anaplastic carcinoma in metastatic neck deposit with occult papillary thyroid carcinoma. To the best of our knowledge, this is the first case in the world literature having anaplastic transformation (AT) in the metastatic neck deposit, right at the presentation with a totally unnoticed PTC clinically. We present this case to emphasize that the transformation process can occur even when the differentiated malignancy in thyroid is small, insignificant or hidden and that metastasis solely can be the presenting feature which can be misleading clinically and even histopathologically. As AC is very aggressive, there is need for early and precise diagnosis & prompt therapeutic intervention.

Anaplastic transformation from papillary thyroid carcinoma with increased serum CA19-9

2005 ◽  
Vol 45 (1) ◽  
pp. 64-67 ◽  
Author(s):  
Masahiro Ogawa ◽  
Hiroki Hori ◽  
Masahiro Hirayama ◽  
Minako Kobayashi ◽  
Taizou Shiraishi ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Anaplastic Transformation
Sign in / Sign up

Export Citation Format

Share Document