Intracellular pH and Metabolic Activity of Long-Chain Dicarboxylic Acid-Producing Yeast Candida tropicalis

2003 ◽  
Vol 96 (4) ◽  
pp. 349-353
Author(s):  
SHUCHEN LIU ◽  
CHUN LI ◽  
LANGYI XIE ◽  
ZHU’AN CAO
Author(s):  
Lihua Zhang ◽  
Xiang Xiu ◽  
Zirui Wang ◽  
Yanjun Jiang ◽  
Han Fan ◽  
...  

Metabolites ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 91 ◽  
Author(s):  
Paul Wood ◽  
Michelle Donohue ◽  
John Cebak ◽  
Taylor Beckmann ◽  
Márcia Messias ◽  
...  

Background: There are currently no blood-based biomarkers for early diagnosis of colorectal cancer. Previous research has suggested that very-long-chain dicarboxylic acid (VLCDCA) 28:4 might be such a biomarker. Methods: Using high-resolution mass spectrometry, we analyzed VLCDCA 28:4 in the plasma of colorectal cancer patients in Italian [n = 62] and Brazilian [n = 52] cohorts. Additionally, we investigated individuals diagnosed with familial adenomatous polyposis (FAP; n = 27), one of the most important clinical forms of inherited susceptibility to colorectal cancer. Results: Decrements in plasma levels of VLCDCA 28:4 were monitored in colorectal cancer patients. These decreases were independent of the stage of tumor development and the individual’s age. However, no decrements in VLCDCA 28:4 were monitored in FAP patients. Conclusions: The plasma levels of VLCDCA 28:4 represent a potential biomarker of sporadic colorectal cancer. In addition, it is possible that resupply of this anti-inflammatory lipid may represent a new therapeutic strategy for CRC and inflammatory disorders.


2019 ◽  
Vol 7 (4) ◽  
pp. 044002 ◽  
Author(s):  
Svetlana A Rodimova ◽  
Aleksandra V Meleshina ◽  
Ekaterina P Kalabusheva ◽  
Erdem B Dashinimaev ◽  
Dmitry G Reunov ◽  
...  

2000 ◽  
Vol 22 (5) ◽  
pp. 391-396 ◽  
Author(s):  
R. Lin ◽  
Z. Cao ◽  
T. Zhu ◽  
Z. Zhang

1989 ◽  
Vol 35 (11) ◽  
pp. 1031-1036 ◽  
Author(s):  
Malcolm C. Modrzakowski ◽  
William R. Finnerty

The microbial dissimilation of long-chain dialkyl ethers by Acinetobacter sp. H01-N involved a terminal methyl group oxidation of the dialkyl ether substrates, resulting in the formation of ether oxygen containing fatty acids of corresponding chain length. An internal carbon–carbon scission of the dialkyl ethers resulted in the formation of end-product ether fatty acids and corresponding dicarboxylic acids. Cellular carbon and energy were derived from the subsequent metabolism of the dicarboxylic acids. Dicarboxylic acid oxidation, activation, and identification of cellular dicarboxylic acids indicated dibasic acids as intermediates in the metabolism of dialkyl ethers.Key words: dialkyl ethers, dicarboxylic acids, fatty acids, Acinetobacter.


2015 ◽  
Vol 6 (40) ◽  
pp. 7133-7137 ◽  
Author(s):  
Florian Stempfle ◽  
Brigitta Schemmer ◽  
Anna-Lena Oechsle ◽  
Stefan Mecking

Thermoplastic polyester elastomers prepared from a plant-oil derived crystallizable long-chain aliphatic α,ω-dicarboxylic acid have been investigated.


2015 ◽  
Vol 181 (3-4) ◽  
pp. 217-224 ◽  
Author(s):  
Melyssa Negri ◽  
Sónia Silva ◽  
Isis Regina Grenier Capoci ◽  
Joana Azeredo ◽  
Mariana Henriques

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