Potential inhibitory effects of d-allose, a rare sugar, on liver preneoplastic lesion development in F344 rat medium-term bioassay

2008 ◽  
Vol 105 (5) ◽  
pp. 545-553 ◽  
Author(s):  
Masanao Yokohira ◽  
Kyoko Hosokawa ◽  
Keiko Yamakawa ◽  
Kousuke Saoo ◽  
Yoko Matsuda ◽  
...  
Keyword(s):  
Preneoplastic Lesion ◽  
Inhibitory Effects ◽  
Medium Term ◽  
Lesion Development ◽  
Rare Sugar ◽  
F344 Rat

scholarly journals The rare sugar d-tagatose protects plants from downy mildews and is a safe fungicidal agrochemical

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Susumu Mochizuki ◽  
Takeshi Fukumoto ◽  
Toshiaki Ohara ◽  
Kouhei Ohtani ◽  
Akihide Yoshihara ◽  
...  
Keyword(s):  
Plant Diseases ◽  
Structural Development ◽  
Phosphomannose Isomerase ◽  
Inhibitory Effects ◽  
Food Ingredient ◽  
Rare Sugar ◽  
Initial Infection ◽  
Downy Mildews ◽  
Wide Range ◽  
Mannose Metabolism

AbstractThe rare sugar d-tagatose is a safe natural product used as a commercial food ingredient. Here, we show that d-tagatose controls a wide range of plant diseases and focus on downy mildews to analyze its mode of action. It likely acts directly on the pathogen, rather than as a plant defense activator. Synthesis of mannan and related products of d-mannose metabolism are essential for development of fungi and oomycetes; d-tagatose inhibits the first step of mannose metabolism, the phosphorylation of d-fructose to d-fructose 6-phosphate by fructokinase, and also produces d-tagatose 6-phosphate. d-Tagatose 6-phosphate sequentially inhibits phosphomannose isomerase, causing a reduction in d-glucose 6-phosphate and d-fructose 6-phosphate, common substrates for glycolysis, and in d-mannose 6-phosphate, needed to synthesize mannan and related products. These chain-inhibitory effects on metabolic steps are significant enough to block initial infection and structural development needed for reproduction such as conidiophore and conidiospore formation of downy mildew.

Testicular toxicity of boric acid (BA): Relationship of dose to lesion development and recovery in the F344 rat

1993 ◽  
Vol 7 (4) ◽  
pp. 305-319 ◽  
Author(s):  
Warren W. Ku ◽  
Robert E. Chapin ◽  
Robert N. Wine ◽  
Beth C. Gladen
Keyword(s):  
Boric Acid ◽  
Testicular Toxicity ◽  
Lesion Development ◽  
F344 Rat ◽  
Relationship Of

Existence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on hepatic preneoplastic lesion development in BN rats

2006 ◽  
Vol 231 (2) ◽  
pp. 304-308 ◽  
Author(s):  
Min Wei ◽  
Taka-aki Hori ◽  
Toshio Ichihara ◽  
Hideki Wanibuchi ◽  
Keiichirou Morimura ◽  
...  
Keyword(s):  
Preneoplastic Lesion ◽  
Lesion Development

scholarly journals Lack of inhibitory effects of the ju-myo protein on development of glutathione S-transferase placental form-positive foci in the male F344 rat liver.

1999 ◽  
Vol 24 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Toshio ICHIHARA ◽  
Hideki WANIBUCHI ◽  
Chyi Chia R. LEE ◽  
Kazuhide NAKAJIMA ◽  
Yoshihisa YANO ◽  
...  
Keyword(s):  
Rat Liver ◽  
Inhibitory Effects ◽  
Glutathione S Transferase ◽  
F344 Rat

scholarly journals The Differential Growth Inhibition of Phytophthora spp. Caused by the Rare Sugar Tagatose Is Associated With Species-Specific Metabolic and Transcriptional Changes

2021 ◽  
Vol 12 ◽  
Author(s):  
Abdessalem Chahed ◽  
Valentina Lazazzara ◽  
Marco Moretto ◽  
Andrea Nesler ◽  
Paola Elisa Corneo ◽  
...  
Keyword(s):  
Mycelial Growth ◽  
Sugar Content ◽  
Amino Acid Content ◽  
Sugar Metabolism ◽  
Inhibitory Effects ◽  
Rare Sugar ◽  
Transcriptional Reprogramming ◽  
Transcriptional Changes ◽  
Negative Impacts ◽  
Species Specific

Tagatose is a rare sugar with no negative impacts on human health and selective inhibitory effects on plant-associated microorganisms. Tagatose inhibited mycelial growth and negatively affected mitochondrial processes in Phytophthora infestans, but not in Phytophthora cinnamomi. The aim of this study was to elucidate metabolic changes and transcriptional reprogramming activated by P. infestans and P. cinnamomi in response to tagatose, in order to clarify the differential inhibitory mechanisms of tagatose and the species-specific reactions to this rare sugar. Phytophthora infestans and P. cinnamomi activated distinct metabolic and transcriptional changes in response to the rare sugar. Tagatose negatively affected mycelial growth, sugar content and amino acid content in P. infestans with a severe transcriptional reprogramming that included the downregulation of genes involved in transport, sugar metabolism, signal transduction, and growth-related process. Conversely, tagatose incubation upregulated genes related to transport, energy metabolism, sugar metabolism and oxidative stress in P. cinnamomi with no negative effects on mycelial growth, sugar content and amino acid content. Differential inhibitory effects of tagatose on Phytophthora spp. were associated with an attempted reaction of P. infestans, which was not sufficient to attenuate the negative impacts of the rare sugar and with an efficient response of P. cinnamomi with the reprogramming of multiple metabolic processes, such as genes related to glucose transport, pentose metabolism, tricarboxylic acid cycle, reactive oxygen species detoxification, mitochondrial and alternative respiration processes. Knowledge on the differential response of Phytophthora spp. to tagatose represent a step forward in the understanding functional roles of rare sugars.

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