scholarly journals Relative Changes in mRNA Expression of Angiopoietins and Receptors Tie in Bovine Corpus Luteum during Estrous Cycle and Prostaglandin F2α-induced Luteolysis: A Possible Mechanism for the Initiation of Luteal Regression

2004 ◽  
Vol 50 (6) ◽  
pp. 619-626 ◽  
Author(s):  
Jun TANAKA ◽  
Tomas J. ACOSTA ◽  
Bajram BERISHA ◽  
Masa TETSUKA ◽  
Motozumi MATSUI ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Corpus Luteum ◽  
Estrous Cycle ◽  
Prostaglandin F2α ◽  
Luteal Regression ◽  
Bovine Corpus Luteum

scholarly journals Expression and regulation of secreted phosphoprotein 1 in the bovine corpus luteum and effects on T lymphocyte chemotaxis

Reproduction ◽  
2013 ◽  
Vol 146 (6) ◽  
pp. 527-537 ◽  
Author(s):  
Daniel H Poole ◽  
Kalidou Ndiaye ◽  
Joy L Pate
Keyword(s):  
Corpus Luteum ◽  
Estrous Cycle ◽  
Cell Function ◽  
Luteal Cell ◽  
Cellular Interactions ◽  
Western Blots ◽  
Luteal Regression ◽  
Luteal Cells ◽  
Bovine Corpus Luteum ◽  
Secreted Phosphoprotein 1

Secreted phosphoprotein 1 (SPP1) in the bovine corpus luteum (CL) regulates cell function during the transitional periods of luteinization and luteal regression. The objectives were to i) characterize SPP1 expression in the CL throughout the estrous cycle, ii) determine factors that regulate SPP1 expression in luteal cells, and iii) examine the role of SPP1 in lymphocyte chemotaxis, proliferation, and function.SPP1mRNA was greater in fully functional (d10) CL and late cycle (d18) CL compared with developing (d4) CL. Additionally,SPP1mRNA increased within 1 h and remained elevated 4 and 8 h following induction of luteolysis with prostaglandin (PG)F2α. Expression of the SPP1 receptor, β3integrin, was not different throughout the estrous cycle but decreased following induction of luteolysis. Expression ofCD44increased during the estrous cycle but did not change during luteal regression. In cultured luteal cells,SPP1mRNA was upregulated by PGF2αand/or tumor necrosis factor α. Western blots revealed the presence of both full-length SPP1 and multiple cleavage products in cultured luteal cells and luteal tissue. Depletion of endogenous SPP1 did not hinder luteal cell-induced lymphocyte proliferation or lymphocyte phenotype but did inhibit lymphocyte migration toward luteal cells. Based on these data, it is concluded that SPP1 is initially activated to establish and maintain cellular interactions between steroidogenic and nonsteroidogenic cells during the development of the CL. Upon induction of luteolysis, SPP1 serves as a signaling molecule to recruit or activate immune cells to facilitate luteal regression and tissue degradation.

Toll-Like Receptor mRNA Expression in the Bovine Corpus Luteum During the Estrous Cycle and Pregnancy.

2012 ◽  
Vol 87 (Suppl_1) ◽  
pp. 174-174
Author(s):  
John Gadsby ◽  
Heather Faircloth ◽  
Melissa D'Annibale ◽  
Peter Farin ◽  
Martin Sheldon
Keyword(s):  
Mrna Expression ◽  
Corpus Luteum ◽  
Estrous Cycle ◽  
Toll Like Receptor ◽  
Receptor Mrna ◽  
Bovine Corpus Luteum

scholarly journals Profiles of prostaglandin F2α metabolite in dairy cattle during luteal regression and pregnancy: implications for corpus luteum maintenance†

2019 ◽  
Vol 101 (1) ◽  
pp. 76-90 ◽  
Author(s):  
Megan A Mezera ◽  
Caleb S Hamm ◽  
Caio A Gamarra ◽  
Rodrigo S Gennari ◽  
Alexandre B Prata ◽  
...  
Keyword(s):  
Corpus Luteum ◽  
Peak Concentration ◽  
Prostaglandin F2α ◽  
Interferon Tau ◽  
Similar Frequency ◽  
Luteal Regression ◽  
Oxytocin Receptors ◽  
Bovine Corpus Luteum ◽  
Reproductive Losses

Abstract Mechanisms of bovine corpus luteum (CL) maintenance during the second month of pregnancy have not been adequately investigated, despite significant reproductive losses. In the first month, interferon-tau is believed to suppress oxytocin-stimulated prostaglandin F2α (PGF) production, yet there are conflicting reports of circulating PGF metabolite (PGFM). In this study, characterization of PGFM and P4 occurred through continuous bihourly blood sampling in cows undergoing CL regression (day 18–21, n = 5), and during the first (day 18–21, n = 5) and second month (day 47–61; n = 16) of pregnancy. Cattle in the second month were assigned to control (n = 8) or oxytocin treatment (n = 8; three pulses to mimic luteolysis) to evaluate if oxytocin receptors were active. All cows but one (which had elevated PGFM prior to oxytocin treatment) maintained the pregnancy. Basal PGFM concentrations were low (11.6 ± 0.7 pg/mL) in the first month but increased 2.54-fold in the second month. Few (0.26 ± 0.12 pulses/day) PGFM pulses with low peak concentrations (28.8 ± 3.1 pg/mL) were observed during the first month of pregnancy, similar to cows not undergoing regression. However, in the second month, frequency (1.10 ± 0.26 pulses/day) and peak concentration (67.2 ± 5.0 pg/mL) of PGFM pulses increased, displaying similar frequency but lower peak PGFM than seen in regression (1.44 ± 0.14 pulses/day; 134.5 ± 18.9 pg/mL). Oxytocin treatment increased likelihood of PGFM pulses post-treatment and increased peak concentration (89.7 ± 10.1 pg/mL) in cows during the second month. Thus, cows have more PGFM pulses during second than first month of pregnancy, possibly induced by endogenous oxytocin, indicating suppression of PGF production is an important mechanism for CL maintenance during first but not second month of pregnancy.

scholarly journals Prostaglandin F2α Regulation of the Bovine Corpus Luteum Endothelin System During the Early and Midluteal Phase1

2001 ◽  
Vol 65 (6) ◽  
pp. 1710-1717 ◽  
Author(s):  
Marietta F. Wright ◽  
Brian Sayre ◽  
E. Keith Inskeep ◽  
Jorge A. Flores
Keyword(s):  
Corpus Luteum ◽  
Prostaglandin F2α ◽  
Bovine Corpus Luteum ◽  
Endothelin System

scholarly journals Effects of prostaglandin F2α on angiogenic and steroidogenic pathways in the bovine corpus luteum may depend on its route of administration

2019 ◽  
Vol 102 (11) ◽  
pp. 10573-10586 ◽  
Author(s):  
A.W. Jonczyk ◽  
K.K. Piotrowska-Tomala ◽  
P. Kordowitzki ◽  
D.J. Skarzynski
Keyword(s):  
Corpus Luteum ◽  
Prostaglandin F2α ◽  
Route Of Administration ◽  
Bovine Corpus Luteum
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