scholarly journals Differential Effects of Flutamide and Di-(2-ethylhexyl) phthalate on Male Reproductive Organs in a Rat Model

2009 ◽  
Vol 55 (4) ◽  
pp. 400-411 ◽  
Author(s):  
Thuy T. B. VO ◽  
Eui-Man JUNG ◽  
Vu Hoang DANG ◽  
Kikyung JUNG ◽  
Jounghee BAEK ◽  
...  
Keyword(s):  
Rat Model ◽  
Reproductive Organs ◽  
Differential Effects ◽  
Male Reproductive Organs ◽  
Ethylhexyl Phthalate

197 DIFFERENTIAL EFFECTS OF FLUTAMIDE AND DI-(2-ETHYLHEXYL) PHTHALATE ON MALE REPRODUCTIVE ORGANS IN A RAT MODEL

2009 ◽  
Vol 21 (1) ◽  
pp. 197
Author(s):  
T. T. B. Vo ◽  
E.-M. Jung ◽  
M.-G. Back ◽  
V. H. Dang ◽  
K.-C. Choi ◽  
...  
Keyword(s):  
Sex Determination ◽  
Microarray Analysis ◽  
Expression Patterns ◽  
Reproductive Organs ◽  
Male Rats ◽  
Seminiferous Tubules ◽  
High Dose ◽  
Total N ◽  
Male Reproductive Organs ◽  
Ethylhexyl Phthalate

Endocrine disruptors (EDs) with androgenic and anti-androgenic effects may alter reproductive function by binding to androgenic receptors (AR) and inducing or modulating AR-dependent responses in the male reproductive system. However, the molecular mechanism(s) underlying these events remains unclear. Thus, in the present study, we elucidated the prenatal effects of maternal testosterone propionate (TP), flutamide (Flu), and di-(2-ethylhexyl) phthalate (DEHP) on male reproductive organs of newborn rats. Pregnant Sprague-Dawley (n = 32 in total, n = 8/each group) rats were treated with these compounds at gestation days 11 to 21, and newborn males (n = 154 in total) were euthanized at post-neonatal day (PND) 63. Interestingly, maternal exposure to Flu or DEHP caused fluctuations in the neonatal levels of serum testosterone (T) and luteinizing hormone (LH). Serum T and LH were up-regulated by Flu, but these hormones were down-regulated by DEHP. The anogenital distances (AGD) of male newborns were detected at PND 1, 21, and 63. Male rats treated prenatally with DEHP (100 mg kg–1 mother’s body weight) or Flu showed an AGD shorter than that of control rats. At PND 63, the sperm concentration, viability, and mobility were reduced in the maternal DEHP and Flu-treated groups. The numbers of seminiferous tubules were reduced in the Flu- and DEHP-treated offspring when compared with vehicle- and TP-treated groups, and the tubules of the testes at PND 63 were disrupted by a high dose of Flu. In addition, we examined differential gene expression patterns in the testes by microarray analysis following ED exposure, particularly in sex determination-related genes. Significantly distinct expressions of sex determination-related genes were observed in the testes by microarray analysis following treatments with different types of EDs in this study. Although Flu and DEHP are considered to be identical with regard to their anti-androgenic effects, their effects on developing male reproductive organs were distinct, suggesting that Flu competes with endogenous T, while DEHP influences a different step in androgenesis.

Intrauterine development, functions and diseases of male reproductive organs

2010 ◽  
Vol 151 (39) ◽  
pp. 1573-1579
Author(s):  
Ákos Jakobovits ◽  
Antal Jakobovits
Keyword(s):  
Reproductive Organs ◽  
Intrauterine Development ◽  
Male Reproductive Organs

A szerzők a központi idegrendszer, a tesztoszteron és származékainak szerepét tárgyalják a férfi nemi szervek méhen belüli fejlődésében. A férfi személyiségét meghatározó jellegzetességek először az emberi fejlődés magzati stádiumában jelentkeznek. Ezek kialakulása a gyermekkorban folytatódik. Pubertás után ezek növekvő mértékben válnak nyilvánvalóvá, és az egyén élete folyamán túlsúlyban maradnak. Az említett folyamatok mind a férfias fenotípust, mind a férfias magatartást befolyásolják. A tesztoszteron és származékai kontrollálják a férfi nemi szervek fejlődését. Hiányuk a női nemi jellegzetességek túlsúlyához vezet, a férfi nemi kromoszómakép ellenére. E jelenségek típusos példája a testicularis feminisatio klinikai képe. Jelen tanulmány különleges figyelmet szentel a reprodukciós szervek azon rendellenességeinek, amelyek a magzatokban ultrahanggal azonosíthatók. Ezen anomáliák legtöbbje antenatalisan hatásosan nem kezelhető. Azok a rendellenességek, amelyek a méhen kívüli életben sem gyógyíthatók, a terhességmegszakítás javallatát képezhetik, amennyiben ultrahangvizsgálattal a kora terhességben kimutathatók. Orv. Hetil., 2010, 39, 1573–1579.

scholarly journals Failed prey or peculiar necrolysis? Isolated ammonite soft body from the Late Jurassic of Eichstätt (Germany) with complete digestive tract and male reproductive organs

2021 ◽  
Vol 140 (1) ◽  
Author(s):  
Christian Klug ◽  
Günter Schweigert ◽  
Helmut Tischlinger ◽  
Helmut Pochmann
Keyword(s):  
Digestive Tract ◽  
Late Jurassic ◽  
Reproductive Organs ◽  
Mantle Cavity ◽  
Soft Body ◽  
Exceptional Preservation ◽  
Attachment Structures ◽  
Male Reproductive Organs ◽  
Marine Basins

AbstractAmmonoid soft parts have been rarely described. Here, we document the soft parts of a perisphinctid ammonite from the early Tithonian of Wintershof near Eichstätt (Germany). This exceptional preservation was enabled by the special depositional conditions in the marine basins of the Solnhofen Archipelago. Here, we document this find and attempt to homologize its parts with various organs such as the digestive tract, reproductive organs, the mantle cavity with gills, and the hyponome, with differing degrees of reservation. Alternative interpretations are also taken into account. We suggest that the soft parts were separated from the conch either taphonomically (following necrolytical processes affecting the attachment structures) or during a failed predation, where a predator (fish or coleoid) removed the soft parts from the conch but then dropped them. This find is interesting because it adds to the knowledge of ammonite anatomy, which is normally hidden in the conch. The reproductive organs show traces of what might have been spermatophores, thus supporting the hypothesis that the microconchs represented the males.

scholarly journals Androgen action in the masculinization programming window and development of male reproductive organs

2010 ◽  
Vol 33 (2) ◽  
pp. 279-287 ◽  
Author(s):  
D. J. MacLeod ◽  
R. M. Sharpe ◽  
M. Welsh ◽  
M. Fisken ◽  
H. M. Scott ◽  
...  
Keyword(s):  
Reproductive Organs ◽  
Androgen Action ◽  
Male Reproductive Organs

Growth Suppressing Effect of Curcuma Comosa Extract on Male Reproductive Organs in Immature Rats

1998 ◽  
Vol 36 (1) ◽  
pp. 44-49 ◽  
Author(s):  
P. Piyachaturawat ◽  
A. Timinkul ◽  
A. Chuncharunee ◽  
A. Suksamrarn
Keyword(s):  
Reproductive Organs ◽  
Curcuma Comosa ◽  
Immature Rats ◽  
Male Reproductive Organs
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