scholarly journals Valproic Acid Treatment from the 4-cell Stage Improves Oct4 Expression and Nuclear Distribution of Histone H3K27me3 in Mouse Cloned Blastocysts

2013 ◽  
Vol 59 (2) ◽  
pp. 196-204 ◽  
Author(s):  
Yuuki ISAJI ◽  
Moeko MURATA ◽  
Naoya TAKAGUCHI ◽  
Toshita MUKAI ◽  
Yosuke TAJIMA ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Acid Treatment ◽  
Cell Stage ◽  
Oct4 Expression ◽  
Nuclear Distribution

Effect of valproic acid treatment on body composition, leptin and soluble leptin receptor in epileptic children

2006 ◽  
Vol 37 (06) ◽  
Author(s):  
M Rauchenzauner ◽  
E Haberlandt ◽  
S Scholl-Bürgi ◽  
D Karall ◽  
E Schönherr ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Body Composition ◽  
Acid Treatment ◽  
Leptin Receptor ◽  
Soluble Leptin Receptor ◽  
Epileptic Children

Effect of Valproic Acid Treatment on Spike-Wave Discharge Patterns during Sleep and Wakefulness

1983 ◽  
Vol 10 (1) ◽  
pp. 56-59 ◽  
Author(s):  
W. Burr ◽  
H. Stefan ◽  
C. Kuhnen ◽  
F. Hoffmann ◽  
H. Penin
Keyword(s):  
Valproic Acid ◽  
Acid Treatment ◽  
Discharge Patterns ◽  
Wave Discharge ◽  
Spike Wave

Effect of valproic acid treatment on body composition, leptin and the soluble leptin receptor in epileptic children

2008 ◽  
Vol 80 (2-3) ◽  
pp. 142-149 ◽  
Author(s):  
M. Rauchenzauner ◽  
E. Haberlandt ◽  
S. Scholl-Bürgi ◽  
D. Karall ◽  
E. Schoenherr ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Body Composition ◽  
Acid Treatment ◽  
Leptin Receptor ◽  
Soluble Leptin Receptor ◽  
Epileptic Children

scholarly journals 432. Valproic Acid Treatment Enhances Hematopoietic Stem and Progenitor Cell Multipotency Ex Vivo for Enhanced Long-Term Engraftment of Gene-Modified Cells

2016 ◽  
Vol 24 ◽  
pp. S171
Author(s):  
Anthony Conway ◽  
Alisa Boyko ◽  
Jeremy Hardin ◽  
Michael C. Holmes ◽  
Gregory J. Cost
Keyword(s):  
Valproic Acid ◽  
Acid Treatment ◽  
Progenitor Cell ◽  
Ex Vivo ◽  
Hematopoietic Stem

Valproic Acid Treatment of Epilepsy in Autistic Twins

1997 ◽  
Vol 29 (4) ◽  
pp. 244-248 ◽  
Author(s):  
Judith A. Childs ◽  
Joan L. Blair
Keyword(s):  
Valproic Acid ◽  
Acid Treatment ◽  
Treatment Of Epilepsy

Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder

2004 ◽  
Vol 56 (5) ◽  
pp. 340-348 ◽  
Author(s):  
Seth D. Friedman ◽  
Stephen R. Dager ◽  
Aimee Parow ◽  
Fuyuki Hirashima ◽  
Christina Demopulos ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Valproic Acid ◽  
Acid Treatment ◽  
Treatment Effects ◽  
Brain Chemistry

scholarly journals Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy

Cells ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 1229 ◽  
Author(s):  
Ida Sofie Grønningsæter ◽  
Hanne Kristin Fredly ◽  
Bjørn Tore Gjertsen ◽  
Kimberley Joanne Hatfield ◽  
Øystein Bruserud
Keyword(s):  
Valproic Acid ◽  
Acute Myeloid Leukemia ◽  
Amino Acid ◽  
Myeloid Leukemia ◽  
Acid Treatment ◽  
Low Dose ◽  
Metabolomic Profiling ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Acute Myeloid

Acute myeloid leukemia (AML) is an aggressive malignancy, and many elderly/unfit patients cannot receive intensive and potentially curative therapy. These patients receive low-toxicity disease-stabilizing treatment. The combination of all-trans retinoic acid (ATRA) and the histone deacetylase inhibitor valproic acid can stabilize the disease for a subset of such patients. We performed untargeted serum metabolomic profiling for 44 AML patients receiving treatment based on ATRA and valproic acid combined with low-dose cytotoxic drugs (cytarabine, hydroxyurea, 6-mercaptopurin) which identified 886 metabolites. When comparing pretreatment samples from responders and non-responders, metabolites mainly belonging to amino acid and lipid (i.e., fatty acid) pathways were altered. Furthermore, patients with rapidly progressive disease showed an extensively altered lipid metabolism. Both ATRA and valproic acid monotherapy also altered the amino acid and lipid metabolite profiles; however, these changes were only highly significant for valproic acid treatment. Twenty-three metabolites were significantly altered by seven-day valproic acid treatment (p < 0.05, q < 0.05), where the majority of altered metabolites belonged to lipid (especially fatty acid metabolism) and amino acid pathways, including several carnitines. These metabolomic effects, and especially the effects on lipid metabolism, may be important for the antileukemic and epigenetic effects of this treatment.

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