scholarly journals Mos and the Mitogen-Activated Protein Kinase Do Not Show Cytostatic Factor Activity in Early Mouse Embryos

2007 ◽  
Vol 53 (6) ◽  
pp. 1175-1182 ◽  
Author(s):  
Koji KASHIMA ◽  
Kiyoshi KANO ◽  
Kunihiko NAITO
Keyword(s):  
Protein Kinase ◽  
Mouse Embryos ◽  
Mitogen Activated Protein Kinase ◽  
Factor Activity ◽  
Mitogen Activated Protein ◽  
Cytostatic Factor ◽  
Early Mouse

Phosphorylation of mitogen-activated protein kinase cascade during early embryo development in the mouse

2000 ◽  
Vol 12 (4) ◽  
pp. 209 ◽  
Author(s):  
Naoki Iwamori ◽  
Kunihiko Naito ◽  
Koji Sugiura ◽  
Hideyuki Kagii ◽  
Masakane Yamashita ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Protein Kinase ◽  
Embryo Development ◽  
Somatic Cells ◽  
Mouse Embryos ◽  
Mapk Cascade ◽  
Mitogen Activated Protein Kinase ◽  
Cell Stage ◽  
Mitogen Activated Protein ◽  
Early Mouse

The mitogen-activated protein kinase (MAPK) cascade is one of the most important signal transduction pathways that regulate the cell cycle in somatic cells. The present study examined the phosphorylation states of components in the MAPK cascade, Raf-1, MEK-1, and extracellular signal regulated kinases (ERKs), which are activated by mitogens, throughout early mouse embryo development and in cultured somatic cells generally. In somatic cells, Raf-1 and MEK-1 were phosphorylated at M-phase and dephosphorylated during interphase. ERKs were not phosphorylated at any stage during the cell cycle. These results were similar to previous findings for the first and second cell cycles of early mouse embryos. In contrast, after the four-cell stage, not only ERKs, but also Raf-1 and MEK-1, were not phosphorylated at any stage during the cell cycle in mouse early embryos. These results suggest that the MAPK cascade in mouse embryos is regulated by the same mechanism as in somatic cells before the two-cell stage, and that regulation is changed to an embryo-specific mechanism after the four-cell stage.

Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos

2004 ◽  
Vol 231 (1) ◽  
pp. 72-87 ◽  
Author(s):  
Yingchun Wang ◽  
Fangfei Wang ◽  
Tong Sun ◽  
Anna Trostinskaia ◽  
Dana Wygle ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Mapk Pathway ◽  
Mouse Embryos ◽  
Mitogen Activated Protein Kinase ◽  
Preimplantation Mouse Embryos ◽  
Mitogen Activated Protein ◽  
Preimplantation Mouse
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