scholarly journals Promotion of Ovarian Follicular Development by Injecting Vascular Endothelial Growth Factor (VEGF) and Growth Differentiation Factor 9 (GDF-9) Genes

2006 ◽  
Vol 52 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Takashi SHIMIZU
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Follicular Development ◽  
Vascular Endothelial ◽  
Differentiation Factor ◽  
Growth Differentiation Factor 9 ◽  
Ovarian Follicular Development ◽  
Endothelial Growth Factor

Direct injection of vascular endothelial growth factor into the ovary of mice promotes follicular development

2004 ◽  
Vol 82 ◽  
pp. 1101-1105 ◽  
Author(s):  
Ramiro Quintana ◽  
Laura Kopcow ◽  
Carlos Sueldo ◽  
Guillermo Marconi ◽  
Nidia Gomez Rueda ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Direct Injection ◽  
Follicular Development ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

The distribution and expression of vascular endothelial growth factor A (VEGFA) during follicular development and atresia in the pig

2020 ◽  
Vol 32 (3) ◽  
pp. 259 ◽  
Author(s):  
Xiaomeng Gao ◽  
Jinbi Zhang ◽  
Zengxiang Pan ◽  
Qifa Li ◽  
Honglin Liu
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Granulosa Cells ◽  
Molecular Level ◽  
Follicular Development ◽  
Vascular Endothelial ◽  
Antral Follicles ◽  
Physiological Processes ◽  
Endothelial Growth Factor

The involvement of vascular endothelial growth factor A (VEGFA) in ovarian physiological processes has been widely reported, but the location and role of VEGFA during follicular atresia remain unknown. This study investigated the distribution and expression of VEGFA during porcine follicular development and atresia. Pig ovaries were obtained, individual medium-sized (3–5mm in diameter) antral follicles were separated and classified into healthy, early atretic or progressively atretic groups. Immunobiology and quantitative techniques were used to investigate the varied follicular distribution of VEGFA at both the morphological and molecular level. The results indicated that VEGFA protein expression peaked in tertiary follicles, mostly distributed in the thecal and inner granulosa layers, during follicular development while VEGFA mRNA was mainly expressed in the inner granulosa layers. Additionally, healthy antral follicles showed a significantly higher expression of VEGFA than atretic follicles in both theca and granulosa cells. Knockdown of VEGFA using siRNA revealed an antiapoptosis effect of VEGFA in cultured pig granulosa cells. Our results increase the knowledge of VEGFA functions in follicles.

scholarly journals Angiogenesis During Follicular Development in the Primate and its Inhibition by Treatment with Truncated Flt-1-Fc (Vascular Endothelial Growth Factor TrapA40)*

Endocrinology ◽  
2001 ◽  
Vol 142 (7) ◽  
pp. 3244-3254 ◽  
Author(s):  
Christine Wulff ◽  
Stanley J. Wiegand ◽  
Philippa T. K. Saunders ◽  
Graeme A. Scobie ◽  
Hamish M. Fraser
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Follicular Development ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Importance of vascular endothelial growth factor (VEGF) in ovarian physiology of mammals

Zygote ◽  
2011 ◽  
Vol 21 (3) ◽  
pp. 295-304 ◽  
Author(s):  
Valdevane Rocha Araújo ◽  
Ana Beatriz Graça Duarte ◽  
Jamily Bezerra Bruno ◽  
Cláudio Afonso Pinho Lopes ◽  
José Ricardo de Figueiredo
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Follicular Development ◽  
Vascular Endothelial ◽  
Follicular Cells ◽  
Ovarian Cells ◽  
Complex Process ◽  
Ovarian Folliculogenesis ◽  
Endothelial Growth Factor

SummaryOvarian folliculogenesis in mammals is a complex process. Several compounds have been tested during in vitro culture of follicular cells for a better understanding of the mechanisms and factors related to ovarian folliculogenesis in mammals. From these compounds, vascular endothelial growth factor (VEGF) can be highlighted, as it is strongly associated with angiogenesis and, in recent years, its presence in ovarian cells has been investigated extensively. Previous studies have shown that the presence of VEGF protein, as well as mRNA expression of its receptor 2 (VEGFR-2) increases during follicular development. Therefore, it is likely that the interaction between VEGF and VEGFR-2 is crucial to promote follicular development. However, few studies on the influence of this factor on follicular development have been reported. This review addresses aspects related to the structural characterization and mechanism of action of VEGF and its receptors, and their biological importance in the ovary of mammals.

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