The wobble hypothesis revisited: Uridine-5-oxyacetic acid is critical for reading of G-ending codons

S. J. Nasvall; P. Chen; G. R. Bjork

doi:10.1261/rna.731007

The wobble hypothesis revisited: Uridine-5-oxyacetic acid is critical for reading of G-ending codons

RNA ◽

10.1261/rna.731007 ◽

2007 ◽

Vol 13 (12) ◽

pp. 2151-2164 ◽

Cited By ~ 54

Author(s):

S. J. Nasvall ◽

P. Chen ◽

G. R. Bjork

Keyword(s):

Wobble Hypothesis ◽

Oxyacetic Acid

Download Full-text

Neuronal damage after the injection of amino-oxyacetic acid into the rat entorhinal cortex: a silver impregnation study

Neuroscience ◽

10.1016/s0306-4522(97)00354-0 ◽

1997 ◽

Vol 82 (4) ◽

pp. 1165-1178 ◽

Cited By ~ 32

Author(s):

F Du ◽

T Eid ◽

R Schwarcz

Keyword(s):

Entorhinal Cortex ◽

Neuronal Damage ◽

Silver Impregnation ◽

Oxyacetic Acid

Download Full-text

The C-S lysis of L-cysteine conjugates by aspartate and alanine aminotransferase enzymes

Human & Experimental Toxicology ◽

10.1177/096032719501400506 ◽

1995 ◽

Vol 14 (5) ◽

pp. 422-427 ◽

Cited By ~ 11

Author(s):

Peter J Gaskin ◽

Harriet J Adcock ◽

Lorraine D Buckberry ◽

Paul H Teesdale-Spittle ◽

P Nicholas Shawl

Keyword(s):

Aspartate Aminotransferase ◽

Alanine Aminotransferase ◽

Pyridoxal Phosphate ◽

Enzyme Inhibitor ◽

Potential Interaction ◽

Direct Inhibition ◽

Porcine Heart ◽

Lyase Activity ◽

Oxyacetic Acid ◽

Dependent Mechanism

One biotransformation pathway which is responsible for the generation of mutagenic and cytotoxic metabolites is that of the C-S lysis (CSL) of L-cysteine conjugates. Thirteen cysteine S-conjugates, synthesised in our labora tories, were incubated with porcine heart aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT), and the C-S lyase activity for each enzyme-sub strate combination was determined. ASAT and ALAT were shown to exhibit CSL activity. It was also demonstrated that this activity was inhibited in the presence of the pyri doxal phosphate (PLP)-dependent enzyme inhibitor amino(oxyacetic acid) (AOAA) confirming the pyridoxal phosphate dependent mechanism by which C-S lysis is known to take place. Since the activities of these enzymes are used as biomarkers for the assessment of organ dam age, the potential interaction of L-cysteine conjugates with them may suppress their activity through direct inhibition.

Download Full-text