scholarly journals Radiological and clinical findings of 25 patients with invasive pulmonary aspergillosis: retrospective analysis of 2150 liver transplantation cases

2012 ◽  
Vol 85 (1016) ◽  
pp. e429-e435 ◽  
Author(s):  
J Qin ◽  
Y Fang ◽  
Y Dong ◽  
K Zhu ◽  
B Wu ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Retrospective Analysis ◽  
Invasive Pulmonary Aspergillosis ◽  
Clinical Findings ◽  
Pulmonary Aspergillosis

Invasive Pulmonary Aspergillosis after Liver Transplantation: Rapid and Complete Response to Combined and Sequential Antifungal Therapy

2008 ◽  
Vol 9 (1) ◽  
pp. 99-104 ◽  
Author(s):  
Mehmet Fatih Can ◽  
Gokhan Yagci ◽  
Levent Gorenek ◽  
Ergun Tozkoparan ◽  
Ismail Ozerhan ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Antifungal Therapy ◽  
Invasive Pulmonary Aspergillosis ◽  
Complete Response ◽  
Pulmonary Aspergillosis

scholarly journals Clinical findings in 19 cases of invasive pulmonary aspergillosis with liver cirrhosis

2014 ◽  
Vol 9 ◽  
Author(s):  
Jiajia Chen ◽  
Qing Yang ◽  
Jianrong Huang ◽  
Lanjuan Li
Keyword(s):  
Risk Factors ◽  
Liver Cirrhosis ◽  
Invasive Pulmonary Aspergillosis ◽  
Clinical Findings ◽  
Pulmonary Aspergillosis ◽  
European Organization ◽  
Aspergillus Infection ◽  
Ctp Score ◽  
High Liver

Background: Aspergillus infection was mostly reported with high mortality rates and a bad prognosis in immunocompromised patients, but data were lacking on the clinical characteristics of aspergillus infection in liver cirrhosis. The aim of this study was to retrospectively assess the morbidity and mortality rate, clinical manifestation, risk factors, and medication of invasive pulmonary aspergillosis (IPA) in liver cirrhosis in The First Affiliated Hospital, College of Medicine, Zhejiang University. Methods: Patients with liver cirrhosis who had been diagnosed with proven or probable IPA by clinical and laboratory parameters from 1st December 2008 to 1st May2012 were retrospectively evaluated for predisposing factors for IPA and clinical outcome. The follow up ended on 30th July2012. IPA was defined according to European Organization for Research and Treatment of Cancer/Mysoses Study group criteria. Results: In total, 6,600 patients with liver cirrhosis were enrolled, and 19 out of these developed IPA. Seventeen out of 19 patients died. Imaging findings such as the halo sign and lower respiratory tract infection symptoms contributed to the early diagnosis of IPA. Possible risk factors for IPA included a high Child-Turcotte-Pugh (CTP) score, broad antibiotic usage and steroid exposure. The use of antifungal compounds may prolong a patient’s life. Conclusions: The mortality of liver cirrhosis with IPA is high. Liver cirrhosis should be considered a risk factor of  IPA. Once patients with high CTP scores and steroid and broad spectrum antibiotics exposure present cough and fever, IPA should be taken into consideration and antifungal agents should be used as soon as possible.

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