scholarly journals Evaluation of the trade-offs encountered in planning and treating locally advanced head and neck cancer: intensity-modulated radiation therapyvsdual-arc volumetric-modulated arc therapy

2012 ◽  
Vol 85 (1020) ◽  
pp. 1539-1545 ◽  
Author(s):  
M Oliver ◽  
D McConnell ◽  
M Romani ◽  
A McAllister ◽  
A Pearce ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Volumetric Modulated Arc Therapy ◽  
Advanced Head ◽  
Intensity Modulated ◽  
Trade Offs ◽  
Arc Therapy

Comparison between hypo-fractionated dose-escalated volumetric modulated arc therapy and conventional concurrent chemo-radiation in locally advanced head and neck cancer: a pilot study

2019 ◽  
Vol 19 (2) ◽  
pp. 132-138
Author(s):  
Ehab Saad ◽  
Riham Hani Radwan ◽  
Eman Abdel Hadi
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Volumetric Modulated Arc Therapy ◽  
Concurrent Chemotherapy ◽  
Comparable Efficacy ◽  
Advanced Head ◽  
Arc Therapy ◽  
To Receive

AbstractObjective:In the treatment of locally advanced head and neck cancer (LA-HNC), both dose escalation and hypo-fractionation can improve tumour control rates with uncertain role of addition of concurrent chemotherapy. We aimed at developing a new radiotherapy protocol for patients not eligible to receive the standard concurrent chemo-radiation therapy (CCRT) with little toxicity profile.Methods:A total of 63 LA-HNC patients were randomised to receive either: 70 Gy in 35 fx in 7 weeks concurrently with cisplatin 100 mg/m2 every 3 weeks for 3 doses (Arm A) or 74 Gy in 33 fx in 6·5 weeks (Arm B). Volumetric modulated arc therapy plans were created for both treatment arms. We compared the local control (LC), progression-free survival (PFS), overall survival (OS) and acute and late toxicity between the two arms.Results:A total of 33 patients were in Arm A versus 30 patients in Arm B with median follow-up 24·2 months. No significant differences in LC, PFS and OS between the two arms. Complete remission occurred in 54·5 and 63·3% of patients in Arms A and B, respectively. All toxicities were significantly less in Arm B than Arm A.Conclusion:Slightly dose-escalated hypo-fractionated regimen is safe and feasible and has comparable efficacy and less acute and late side effects than conventional dose CCRT with avoidance of chemotherapy-related toxicities in LA-HNC patients.

Residual deficits in quality of life one year after intensity-modulated radiotherapy for patients with locally advanced head and neck cancer

2015 ◽  
Vol 191 (6) ◽  
pp. 501-510 ◽  
Author(s):  
Silke Tribius ◽  
Marieclaire Raguse ◽  
Christian Voigt ◽  
Adrian Münscher ◽  
Alexander Gröbe ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
Advanced Head ◽  
Intensity Modulated ◽  
One Year

Intensity-modulated radiotherapy or volumetric-modulated arc therapy in patients with head and neck cancer: Focus on salivary glands dosimetry

Head & Neck ◽  
2016 ◽  
Vol 38 (7) ◽  
pp. 1028-1034 ◽  
Author(s):  
Alexis Vallard ◽  
Jean-Baptiste Guy ◽  
Sylvie Mengue Ndong ◽  
Nicolas Vial ◽  
Romain Rivoirard ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Salivary Glands ◽  
Neck Cancer ◽  
Volumetric Modulated Arc Therapy ◽  
Intensity Modulated Radiotherapy ◽  
Intensity Modulated ◽  
Arc Therapy
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