Overview of MRI for pulmonary functional imaging

2021 ◽  
pp. 20201053
Author(s):  
Yoshiharu Ohno ◽  
Satomu Hanamatsu ◽  
Yuki Obama ◽  
Takahiro Ueda ◽  
Hirotaka Ikeda ◽  
...  
Keyword(s):  
Functional Imaging ◽  
Disease Process ◽  
Pulmonary Diseases ◽  
Morphological Evaluation ◽  
Ventilation Imaging ◽  
Biomechanical Evaluation ◽  
Future Direction ◽  
Underlying Pathophysiology ◽  
Early Phases ◽  
Insight Into

Morphological evaluation of the lung is important in the clinical evaluation of pulmonary diseases. However, the disease process, especially in its early phases, may primarily result in changes in pulmonary function without changing the pulmonary structure. In such cases, the traditional imaging approaches to pulmonary morphology may not provide sufficient insight into the underlying pathophysiology. Pulmonary imaging community has therefore tried to assess pulmonary diseases and functions utilizing not only nuclear medicine, but also CT and MR imaging with various technical approaches. In this review, we overview state-of-the art MR methods and the future direction of: (1) ventilation imaging, (2) perfusion imaging and (3) biomechanical evaluation for pulmonary functional imaging.

Moving Songs

2019 ◽  
pp. 590-606
Author(s):  
Sally Treloyn ◽  
Matthew Dembal Martin ◽  
Rona Goonginda Charles
Keyword(s):  
Cultural Heritage ◽  
Knowledge Transmission ◽  
Intercultural Relationships ◽  
Cultural Negotiation ◽  
Intercultural Collaboration ◽  
Present Collection ◽  
Intergenerational Knowledge ◽  
Early Phases ◽  
Insight Into

Repatriation has become almost ubiquitous in ethnomusicological research on Australian Indigenous song. This article provides insights into processes of a repatriation-centered song revitalization project in the Kimberley, northwest Australia. Authored by an ethnomusicologist and two members of the Ngarinyin cultural heritage community, the article provides firsthand accounts of the early phases of a long-term repatriation-centered project referred to locally as the Junba Project. The authors provide a sample of narratives and dialogues that deliver insight into experiences of the work of identifying recordings “in the archive” and cultural negotiation and use of recordings “on Country.” The entanglement of local epistemological frameworks with past and present collection, archival research, repatriation, and dissemination for intergenerational knowledge transmission between spirits, Country, and the living, is explored, showing how recordings move song knowledge from community to archive to community and from generation to generation, and move people in present-day communities. The chapter considers how these “moving songs” allow an interrogation of the fraught endeavor of intercultural collaboration in the pursuit of revitalizing Indigenous song traditions. It positions repatriation as a method that can support intergenerational knowledge transmission and as a method to consider past and present intercultural relationships within research projects and between cultural heritage communities and collecting institutions.

scholarly journals PUBLICATION TREND ON TRAVEL PREFERENCES OF SENIOR TOURISTS FROM 2000 TO 2020

2021 ◽  
Vol 6 (26) ◽  
pp. 172-185
Author(s):  
Nurul Ain Farhana Zainordin ◽  
Syed Muhammad Rafy Syed Jaafar ◽  
Nurul Diyana Md Khairi
Keyword(s):  
Literature Review ◽  
The Other ◽  
Ageing Population ◽  
Market Segment ◽  
Future Directions ◽  
Tourism Research ◽  
Review Analysis ◽  
Future Direction ◽  
Insight Into

The ageing population is the crucial phenomenon that has led to the new market segment in tourism known as 'senior tourists.' A senior tourist is determined as an older traveller or grey tourist. The number of elderly keeps growing throughout time; hence, grey tourists will be relevant preferences, differing from the younger tourists. This paper aims to evaluate the relevant studies regarding travel preferences that involve senior tourists. The objective is to understand the publication trend behind the development of travel preferences for senior tourists. The findings suggest that the overall travel preferences among senior tourists studied include 12 aspects of travel preferences. Researchers tend to focus on the aspect of accommodation among senior tourists compared to the other elements. At the end of the review, this paper is set out to outline the literature review analysis to provide greater insight into the development of travel preferences among grey tourists in tourism research from 2000 to 2020. This paper's output offers future directions to explore the offer trends and future direction in tourism and behaviour literature.

scholarly journals Condition Monitoring Technologies for Synthetic Fiber Ropes - a Review

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Espen Oland ◽  
Rune Schlanbusch ◽  
Shaun Falconer
Keyword(s):  
Condition Monitoring ◽  
State Of The Art ◽  
Degradation Process ◽  
Synthetic Fiber ◽  
Physical Parameters ◽  
The Subject ◽  
Condition Monitoring System ◽  
Future Direction ◽  
Monitoring Technologies ◽  
Insight Into

This paper presents a review of different condition monitoring technologies for fiber ropes. Specifically, it presents an overview of the articles and patents on the subject, ranging from the early 70’s up until today with the state of the art. Experimental results are also included and discussed in a conditionmonitoring context,where failuremechanisms and changes in physical parameters give improved insight into the degradation process of fiber ropes. From this review, it is found that automatic width measurement has received surprisingly little attention, and might be a future direction for the development of a continuous condition monitoring system for synthetic fiber ropes.

Overview of neuroimaging

2019 ◽  
pp. 31-44
Author(s):  
Tomasz Matys ◽  
Daniel. J. Scoffings ◽  
Tilak Das
Keyword(s):  
Essential Role ◽  
Imaging Techniques ◽  
Disease Process ◽  
Future Directions ◽  
Anatomical Imaging ◽  
Radiological Methods ◽  
Physical Principles ◽  
Insight Into ◽  
Individual Disease

Imaging plays an essential role in the diagnosis and treatment of neurosurgical conditions. This chapter discusses the basic physical principles, applications, and limitations of the main imaging techniques used in neurosurgical practice, and highlights potential future directions of functional and molecular neuroimaging. Current conventional radiological methods allow demonstration of anatomical and macroscopic pathological features of disease with excellent sensitivity and resolution. Functional imaging methods that have enabled insight into a variety of physiological and pathological phenomena are also described, and are an important first step beyond anatomical imaging towards more precise characterization of the disease process. These methods however remain generally non-specific, demonstrating changes that are common endpoints of many possible pathological pathways. This chapter also covers current neuroradiology imaging modalities that are useful in neurosurgical practice, and focuses on the general usefulness and limitations of neuroradiological methods rather than the imaging manifestations of individual disease processes, which are discussed elsewhere in this book.

scholarly journals Pigmentary keratitis in pugs in the United Kingdom: prevalence and associated features

2019 ◽  
Vol 15 (1) ◽  
Author(s):  
S. Maini ◽  
R. Everson ◽  
C. Dawson ◽  
Y. M. Chang ◽  
C. Hartley ◽  
...  
Keyword(s):  
United Kingdom ◽  
Longitudinal Studies ◽  
Lower Eyelid ◽  
Disease Prevalence ◽  
Breeding Strategies ◽  
The United Kingdom ◽  
Social Events ◽  
Prospective Longitudinal ◽  
Underlying Pathophysiology ◽  
Insight Into

Abstract Background Pigmentary keratitis (PK) is commonly recognised in Pugs, but its aetiology is not completely understood. The aim of this study was to determine the prevalence and associated features of PK in Pugs in the United Kingdom (UK). Results A total of 210 Pugs (420 eyes) were recruited from 12 UK dog shows and social events. The median age of Pugs recruited was 2.50 years (range 0.25–16.25 years). Pigmentary keratitis was detected in 369/420 (87.8%) eyes and in at least one eye 193/210 (91.9%) Pugs, of which 17/193 (8.8%) were affected unilaterally and 176/193 (91.2%) bilaterally. Pigmentary keratitis was typically mild to moderate (46.3 and 49.9% of eyes, respectively). Detection of PK was significantly associated with increased age (P = 0.002) and the presence of medial entropion of the lower eyelid (MELE) (P = 0.001). Severity of PK was significantly associated with the grade of MELE (P < 0.001). There was also a correlation between the presence of limbal pigment and PK (P = 0.036) that warrants further study. Conclusions This study estimated a high disease prevalence of PK in UK Pugs, and demonstrated significant associations with age and the presence of MELE. These associations, which have not been previously reported, offer an insight into the underlying pathophysiology of this condition in Pugs. The results encourage further population research, such as prospective longitudinal studies. These findings also support the development of clinical and breeding strategies based on the reduction of MELE and, possibly, limbal pigment.

Automated Dispensing Devices

2000 ◽  
Vol 35 (6) ◽  
pp. 666-670 ◽  
Author(s):  
Darryl S. Rich
Keyword(s):  
Home Care ◽  
Accreditation Process ◽  
Joint Commission ◽  
Practice Environment ◽  
Fair Game ◽  
Future Direction ◽  
Insight Into ◽  
The Joint Commission

This column addresses questions from readers about any issue, process, standard, or future direction of the Joint Commission, whether it relates to home care, the hospital, or other practice environment. The objective is to give you a better insight into the Joint Commission accreditation process in your own practice site. Any question is fair game.

Case-based discussions in onco-nephrology

2020 ◽  
Vol 4 (3) ◽  
pp. 135-144
Author(s):  
Kammi J Henriksen ◽  
Jonathan J Hogan ◽  
Ala Abudayyeh ◽  
Nupur Mistry ◽  
Jay L Koyner ◽  
...  
Keyword(s):  
Targeted Therapies ◽  
Kidney Biopsy ◽  
Clinical Presentation ◽  
Kidney Diseases ◽  
Clinicopathologic Features ◽  
Wide Range ◽  
Therapeutic Considerations ◽  
Underlying Pathophysiology ◽  
Insight Into ◽  
Case Based

Onco-nephrology encompasses a wide range of complex problems including nephrotoxicity from traditional chemotherapy and targeted therapies, paraneoplastic kidney diseases, tumor- or treatment-related microangiopathies and glomerulonephritis, and kidney injuries associated with dysproteinemia, among others. To bring these topics to life, we present a case-based discussion of clinicopathologic features that we have encountered in our daily practices. We hope these discussions of clinical presentation, kidney biopsy findings, underlying pathophysiology, and therapeutic considerations will provide insight into recognizing and treating this expanding spectrum of diseases.

Respiratory Failure and the Indications for Mechanical Ventilation

2017 ◽  
Author(s):  
John W. Kreit
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Gas Exchange ◽  
Disease Process ◽  
Upper Airway ◽  
Lower Airway ◽  
Vital Functions ◽  
Refractory Hypoxemia ◽  
Ventilation Failure ◽  
Underlying Pathophysiology

Respiratory failure occurs when a disease process significantly interferes with the respiratory system’s vital functions and causes arterial hypoxemia, hypercapnia, or both. Typically, respiratory failure is divided into three categories based on the underlying pathophysiology: ventilation failure, oxygenation failure, and oxygenation-ventilation failure. With severe disturbances in gas exchange, mechanical ventilation is often needed to assist the respiratory system and restore the PaCO2, PaO2, or both, to normal. Respiratory Failure and the Indications for Mechanical Ventilation defines and describes the three types of respiratory failure and reviews the four indications for intubation and mechanical ventilation—acute or acute-on-chronic hypercapnia, refractory hypoxemia, inability to protect the lower airway, and upper airway obstruction.

Updates on the use of liposomes for active tumor targeting in cancer therapy

Nanomedicine ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. 303-318 ◽  
Author(s):  
Wei Yan ◽  
Sharon SY Leung ◽  
Kenneth KW To
Keyword(s):  
Preparation Method ◽  
Cancer Therapeutics ◽  
Active Targeting ◽  
Anticancer Drug Delivery ◽  
Liposomal Formulations ◽  
Simple Preparation ◽  
Low Toxicity ◽  
Future Direction ◽  
New Anticancer Drugs ◽  
Insight Into

In the development of cancer chemotherapy, besides the discovery of new anticancer drugs, a variety of nanocarrier systems for the delivery of previously developed and new chemotherapeutic drugs have currently been explored. Liposome is one of the most studied nanocarrier systems because of its biodegradability, simple preparation method, high efficacy and low toxicity. To make the best use of this vehicle, a number of multifunctionalized liposomal formulations have been investigated. The objective of this review is to summarize the current development of novel active targeting liposomal formulations, and to give insight into the challenges and future direction of the field. The recent studies in active targeting liposomes suggest the great potential of precise targeted anticancer drug delivery in cancer therapeutics.

CHIVA, ASVAL and related techniques – Concepts and evidence

2015 ◽  
Vol 30 (2_suppl) ◽  
pp. 42-45 ◽  
Author(s):  
Sarah Onida ◽  
Alun H Davies
Keyword(s):  
Minimally Invasive ◽  
Varicose Veins ◽  
Disease Process ◽  
Chronic Venous Disease ◽  
Treatment Modalities ◽  
Venous Disease ◽  
Invasive Treatment ◽  
Venous Circulation ◽  
Underlying Pathophysiology

Chronic venous disease (CVD) is a highly prevalent condition with significant effects on patients’ quality of life. Despite this, the underlying pathophysiology of venous disease still remains unclear. Two schools of thought exist, explaining the development and propagation of venous disease as an “ascending” and “descending” process, respectively. The descending theory, stating that CVD is secondary to proximal disease (e.g. saphenofemoral/saphenous incompetence), is the most widely accepted when planning treatment aiming to remove or destroy the junction or truncal veins. The ascending theory, describing the disease process as developing in the lower most part of the leg and propagating cranially, aims to re-route the venous circulation via minimally invasive interventions. Classically, superficial venous insufficiency has been treated with the removal of the incompetent trunk, via open surgery or, increasingly, with endovenous interventions. Minimally invasive treatment modalities aiming to preserve the saphenous trunk, such as CHIVA and ASVAL, may also play an important role in the treatment of the patient with varicose veins.

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