scholarly journals Vulnerable plaque imaging using 18F-sodium fluoride positron emission tomography

2020 ◽  
Vol 93 (1113) ◽  
pp. 20190797 ◽  
Author(s):  
Jacek Kwiecinski ◽  
Piotr J Slomka ◽  
Marc R Dweck ◽  
David E Newby ◽  
Daniel S Berman
Keyword(s):  
Coronary Artery Disease ◽  
Positron Emission Tomography ◽  
Coronary Artery ◽  
Sodium Fluoride ◽  
Imaging Modality ◽  
Emission Tomography ◽  
Plaque Morphology ◽  
Non Invasive ◽  
Positron Emission ◽  
Artery Disease

Positron emission tomography (PET) with 18F-sodium fluoride (18F-NaF) has emerged as a promising non-invasive imaging modality to identify high-risk and ruptured atherosclerotic plaques. By visualizing microcalcification, 18F-NaF PET holds clinical promise in refining how we evaluate coronary artery disease, shifting our focus from assessing disease burden to atherosclerosis activity. In this review, we provide an overview of studies that have utilized 18F-NaF PET for imaging atherosclerosis. We discuss the associations between traditional coronary artery disease measures (risk factors) and 18F-NaF plaque activity. We also present the data on the histological validation as well as show how 18F-NaF uptake is associated with plaque morphology on intravascular and CT imaging. Finally, we discuss the technical challenges associated with 18F-NaF coronary PET highlighting recent advances in this area.

scholarly journals Positron Emission Tomography in the Diagnosis and Management of Coronary Artery Disease

Medicina ◽  
2018 ◽  
Vol 54 (3) ◽  
pp. 47 ◽  
Author(s):  
Eglė Kazakauskaitė ◽  
Diana Žaliaduonytė-Pekšienė ◽  
Eglė Rumbinaitė ◽  
Justas Keršulis ◽  
Ilona Kulakienė ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Positron Emission Tomography ◽  
Coronary Artery ◽  
Emission Tomography ◽  
Imaging Modalities ◽  
Lv Function ◽  
Non Invasive ◽  
Positron Emission ◽  
Pet Ct ◽  
Artery Disease

Cardiac positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) are encouraging precise non-invasive imaging modalities that allow imaging of the cellular function of the heart, while other non-invasive cardiovascular imaging modalities are considered to be techniques for imaging the anatomy, morphology, structure, function and tissue characteristics. The role of cardiac PET has been growing rapidly and providing high diagnostic accuracy of coronary artery disease (CAD). Clinical cardiology has established PET as a criterion for the assessment of myocardial viability and is recommended for the proper management of reduced left ventricle (LV) function and ischemic cardiomyopathy. Hybrid PET/CT imaging has enabled simultaneous integration of the coronary anatomy with myocardial perfusion and metabolism and has improved characterization of dysfunctional areas in chronic CAD. Also, the availability of quantitative myocardial blood flow (MBF) evaluation with various PET perfusion tracers provides additional prognostic information and enhances the diagnostic performance of nuclear imaging.

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