scholarly journals Physiological motion of the optic chiasm and its impact on stereotactic radiosurgery dose

2019 ◽  
Vol 92 (1099) ◽  
pp. 20190170 ◽  
Author(s):  
Michael Xiang ◽  
Cynthia Chan ◽  
Lei Wang ◽  
Khushboo Jani ◽  
Samantha J. Holdsworth ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Lateral Displacement ◽  
Human Subjects ◽  
Optic Chiasm ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Average Motion ◽  
Anatomical Localization ◽  
Measured Displacement ◽  
Dose Constraints

Objective: Avoidance of radiation-induced optic neuropathy (RION) from stereotactic radiosurgery (SRS) requires precise anatomical localization; however, no prior studies have characterized the physiologic motion of the optic chiasm. We measured the extent of chiasm motion and its impact on SRS dose. Methods: In this cross-sectional study, serial MRI was performed in multiple planes in 11 human subjects without optic pathway abnormalities to determine chiasm motion across time. Subsequently, the measured displacement was applied to the hypothetical chiasm dose received in 11 patients treated with SRS to a perichiasmatic lesion. Results: On sagittal images, the average anteroposterior chiasm displacement was 0.51 mm [95% confidence interval (CI) 0.27 – 0.75 mm], and the average superior-inferior displacement was 0.48 mm (95% CI 0.22 – 0.74 mm). On coronal images, the average superior–inferior displacement was 0.42 mm (95% CI 0.13 – 0.71 mm), and the average lateral displacement was 0.75 mm (95% CI 0.42 – 1.08 mm). In 11 patients who underwent SRS to a perichiasmatic lesion, the average displacements increased the maximum chiasm dose (Dmax) by a mean of 14 % (range 6–23 %; p < 0.001). Conclusion: Average motion of the optic chiasm was approximately 0.50–0.75 mm, which increased chiasm Dmax by a mean of 14%. In the occasional patient with higher-than-average chiasm motion in a region of steep dose gradient, the increase in chiasm Dmax and risk of RION could be even larger. Similarly, previously reported chiasm dose constraints may underestimate the true dose received during radiosurgery. Advances in knowledge: To limit the risk of RION, clinicians may consider adding a 0.50–0.75 mm expansion to the chiasm avoidance structure.

Assessment of Student’s Knowledge, Attitude and Perceptions about Autopsy

2021 ◽  
Vol 15 (10) ◽  
pp. 2853-2855
Author(s):  
Deedar Ali ◽  
Sono Mal ◽  
Inayatullah Magsi ◽  
Sadia Abdul Qayyum ◽  
Shahla Imran ◽  
...  
Keyword(s):  
Medical Curriculum ◽  
Human Subjects ◽  
Cross Sectional Study ◽  
Vital Role ◽  
Human Anatomy ◽  
Autopsy Study ◽  
Cross Sectional ◽  
Unnatural Death ◽  
Causes Of Deaths ◽  
Clinical Conditions

Background: The clinical autopsy is a common term used to help in the identification of person’s clinical conditions and causes of deaths, however, the autopsy plays a vital role in the justice and jurisprudence. Objective: To determine the knowledge, beliefs and understanding of medical students regarding the autopsy Study Design: Descriptive, cross-sectional study Place and Duration of Study: Peoples University of Medical & Health Sciences for Women (PUMHSW) Nawabshah (SBA) Sindh Pakistan from 1st March 2021 to 31st August 2021. Methodology: Four hundred and twenty eight female students of 3rd year and 4th year were enrolled. The students were recruited based on random sampling method. Results: There were 221 students between 23 to 24 years followed by 207 students between 20 to 22 years. One hundred and sixty five were attended 3 autopsies. Autopsy is necessary for all unnatural death and the responses were 327 yes and 101 were no. Education of autopsy is mandatory for the career and the responses were 146 yes and 282 were no understanding, videos are helpful for autopsies and the responses were 178 yes and 250 were no. Conclusion: The autopsies and experiences regarding the autopsies was integral part of medical curriculum. The studies of autopsies are helpful to understand the human anatomy and reasons of deaths. The students’ perceptions supported the medical autopsies as important part of curriculum and teaching particular anatomy of human subjects. Key words: Knowledge, Attitude, Perceptions, Autopsy

scholarly journals Qualidade de vida e função sexual após o câncer cervical: estudo transversal

2016 ◽  
Vol 15 ◽  
pp. 542
Author(s):  
Rafaella Araújo Correia ◽  
Lays Janaina Prazeres Marques ◽  
Solange Laurentino dos Santos ◽  
Cristine Vieira do Bonfim
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Sexual Function ◽  
Human Subjects ◽  
Pearson Correlation ◽  
Descriptive Analysis ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Clinic Hospital

Aim:  To  analyze  the  quality  of  life  and  sexual  function of  women undergoing treatment for cervical cancer. Methods: A cross-sectional study of hospital-based  census,  in  which  a  total  of  90  women  treated  for  cervical cancer  at  the  Clinic Hospital  of  Federal  University  of  Pernambuco  (UFPE)  in  2015  will  be  interviewed.  The following  instruments  will  be  used:  WHOQOL-BREF,  Female  Sexual  Function  Index (FSFI),  and  an  instrument  specifically  developed  for  this  research  to  characterize  the population to be studied. A descriptive analysis and measures of central tendencies and dispersion,  as  well  as  Pearson  correlation  and  Student  t-tests  will  be  conducted.  The project was approved by the Ethics Committee for Research Involving Human Subjects of the UFPE Health Sciences Center. Expected results: to identify most affected areas of quality  of  life  (QOL)  and  sexual  function  in  women  studied  and  the  most  harmful treatment forms.

scholarly journals ASSOCIATION OF VARICOCELE WITH OLIGOSPERMIA AND AZOSPERMIA

1969 ◽  
Vol 3 (2) ◽  
pp. 303-307
Author(s):  
NAIK ZADA ◽  
SHAFI ULLAH KHAN ◽  
RIAZ AHMAD KHAN
Keyword(s):  
Sperm Count ◽  
Human Subjects ◽  
Semen Analysis ◽  
Cross Sectional Study ◽  
Semen Parameters ◽  
Male Factor ◽  
Cross Sectional ◽  
Seminal Parameters ◽  
The Mean ◽  
Age Range

OBJECTIVE: To determine the frequency of abnormal semen parameters among patients presenting withvaricocele1METHODS:It was a descriptive cross-sectional study conducted at the Department of Urology Institute ofkidney diseases Hayat Abad Medical Complex Peshawar and Cenna hospital Saidu Sharif Swat. The studywas carried out on 139 human subjects with clinical evidence of varicocele between age range of 15-45years.The diagnosis of varicocele was based on palpable and/or visible scrotal lump of testicular veins(pampiniform plexus) and was diagnosed on the basis of clinical examination. Semen analysis was carriedout in all these patients and information wascollected on pre designed proforma.RESULTS:The study included a total of 139 patients with varicocele. The mean age of patient was 30 years(15-45) among the patients having symptoms of varicocele. The Mean ±SD for duration of varicocelesymptoms was 9.32 ± 9.70 months. 6.5% (n=9) patients were having azoospermia and 20.1% (n=28)patients had oligozoospermia.CONCLUSION: Patients with varicocele have poor seminal parameters in terms of sperm count i.e.oligozoospermia and azoospermia responsible for male factor infertility in majority ofcases.KEYWORDS:varicocele;seminal parameters;sperm count, infertility

Attitude and Practice Towards Aflatoxin Contamination in Food and Sociodemographic Factors Contributed Toward Urinary AFM1 Occurrence Among Residents in Hulu Langat, Selangor, Malaysia

2020 ◽  
Author(s):  
Siti Husna Sulaiman ◽  
Wei Lin Chang ◽  
Rosita Jamaluddin ◽  
Mohd Redzwan Sabran
Keyword(s):  
Household Income ◽  
Human Subjects ◽  
Sociodemographic Factors ◽  
Cross Sectional Study ◽  
Mean Value ◽  
Aflatoxin Contamination ◽  
Cross Sectional ◽  
Monthly Household Income ◽  
Attitude And Practice ◽  
The Mean

Abstract Background: Aflatoxin occurrence could be affected by several factors. This study aimed to assess the association between knowledge, attitude and practice (KAP) towards aflatoxin and sociodemographic factors with urinary AFM1 occurrence among residents in Hulu Langat, Selangor. Methods: A cross-sectional study was conducted among healthy Malaysian adults aged 18 to 60 years in six subdistricts of Hulu Langat, Selangor. Sociodemographic factors and KAP towards aflatoxin were assessed via questionnaires while morning urine sample was collected for AFM 1 analysis. Of 444 respondents, the urinary AFM 1 level was detected in 199 samples (detection rate = 44.8 %). From 37 positive samples with AFM 1 level above the detection limit of 0.64 ng/ml, the mean value was 1.23 ± 0.91 ng/ml with a range of 0.65 – 5.34 ng/ml (median = 0.89 ng/ml). The variables were examined based on the occurrence of urinary AFM 1 biomarker. Results: Findings showed that there were significant differences in urinary AFM1 occurrence across ethnicity ( p <0.01), age group ( p <0.05), monthly household income ( p <0.01), as well as attitude ( p <0.01) and practice ( p <0.05) towards aflatoxin contamination in food. Binomial logistic regression confirmed that ethnicity and monthly household income were the factors contributing to urinary aflatoxin occurrence ( p <0.01). Chinese were 3.20 times more likely to have aflatoxin exposure than the non-Chinese. Detected urinary AFM 1 was more common among household with income more than RM 1500 monthly. Conclusion: The results provided an insight to explain the variation in aflatoxin occurrence among the population. Trial registration: Ethics Committee for Research Involving Human Subjects Universiti Putra Malaysia (JKEUPM), project number: FPSK (EXP16) P047

scholarly journals Awareness about sanitary toilets in a rural area of north Karnataka, India: a cross sectional study

2017 ◽  
Vol 4 (2) ◽  
pp. 363
Author(s):  
Sidharaj Jeratagi ◽  
Yogesh Kumar ◽  
Maheshwar D. Mallapur
Keyword(s):  
Rural Areas ◽  
Human Subjects ◽  
Cross Sectional Study ◽  
Demographic Variables ◽  
Cross Sectional ◽  
Medical College ◽  
Development Goals ◽  
Socioeconomic Strata ◽  
Study Participants ◽  
Jawaharlal Nehru

Background: As improvement in sanitation is one of the goal among Millennium Development Goals, awareness and lack of sanitary toilet in rural areas is still a major public problem.  The objectives were to study the awareness level about sanitary toilet in a rural area.Methods: Study participants included 400 adults from Sonatti village of Belgaum district of north Karnataka. Pre-tested questionnaire was used to collect necessary information including socio demographic variables by house to house survey. Ethical clearance was obtained from IEC on human subjects of Jawaharlal Nehru Medical College, Belgaum. Informed consent was taken before collecting data from all the participants.Results: In this study most of study participants 173 (43.3%) were aged between 18 to 30 years. Majority of 164 (41.0%) were farmers and most of them 197 (49.2%) belonged to Class IV socioeconomic strata. Only 3(0.7%) had a household latrine. About 80% of participants showed average knowledge, 50% of participants showed good attitude and 62% of participants showed average practice. Awareness of sanitary toilet use was significantly associated with higher socioeconomic status and higher education.  Conclusions: The present study revealed that awareness about sanitary latrine was very poor. Practice of open air defecation was very high. The overall assessment of participants revealed that there is a need to create more awareness regarding sanitary toilet use in rural areas.

Discovery and Validation of Banana Intake Biomarkers Using Untargeted Metabolomics in Human Intervention and Cross-sectional Studies

2019 ◽  
Vol 149 (10) ◽  
pp. 1701-1713 ◽  
Author(s):  
Natalia Vázquez-Manjarrez ◽  
Christoph H Weinert ◽  
Maria M Ulaszewska ◽  
Carina I Mack ◽  
Pierre Micheau ◽  
...  
Keyword(s):  
Health Effects ◽  
Human Subjects ◽  
Ultra Performance Liquid Chromatography ◽  
Cross Sectional Study ◽  
Untargeted Metabolomics ◽  
Bioactive Metabolites ◽  
Controlled Study ◽  
Xanthurenic Acid ◽  
Dietary Interventions ◽  
Cross Sectional

ABSTRACT Background Banana is one of the most widely consumed fruits in the world. However, information regarding its health effects is scarce. Biomarkers of banana intake would allow a more accurate assessment of its consumption in nutrition studies. Objectives Using an untargeted metabolomics approach, we aimed to identify the banana-derived metabolites present in urine after consumption, including new candidate biomarkers of banana intake. Methods A randomized controlled study with a crossover design was performed on 12 healthy subjects (6 men, 6 women, mean ± SD age: 30.0 ± 4.9 y; mean ± SD BMI: 22.5 ± 2.3 kg/m2). Subjects underwent 2 dietary interventions: 1) 250 mL control drink (Fresubin 2 kcal fiber, neutral flavor; Fresenius Kabi), and 2) 240 g banana + 150 mL control drink. Twenty-four-hour urine samples were collected and analyzed with ultra-performance liquid chromatography coupled to a quadrupole time-of-flight MS and 2-dimensional GC-MS. The discovered biomarkers were confirmed in a cross-sectional study [KarMeN (Karlsruhe Metabolomics and Nutrition study)] in which 78 subjects (mean BMI: 22.8; mean age: 47 y) were selected reflecting high intake (126–378 g/d), low intake (47.3–94.5 g/d), and nonconsumption of banana. The confirmed biomarkers were examined singly or in combinations, for established criteria of validation for biomarkers of food intake. Results We identified 33 potentially bioactive banana metabolites, of which 5 metabolites, methoxyeugenol glucuronide (MEUG-GLUC), dopamine sulfate (DOP-S), salsolinol sulfate, xanthurenic acid, and 6-hydroxy-1-methyl-1,2,3,4-tetrahydro-β-carboline sulfate, were confirmed as candidate intake biomarkers. We demonstrated that the combination of MEUG-GLUC and DOP-S performed best in predicting banana intake in high (AUCtest = 0.92) and low (AUCtest = 0.87) consumers. The new biomarkers met key criteria establishing their current applicability in nutrition and health research for assessing the occurrence of banana intake. Conclusions Our metabolomics study in healthy men and women revealed new putative bioactive metabolites of banana and a combined biomarker of intake. These findings will help to better decipher the health effects of banana in future focused studies. This study was registered at clinicaltrials.gov as NCT03581955 and with the Ethical Committee for the Protection of Human Subjects Sud-Est 6 as CPP AU 1251, IDRCB 2016-A0013–48; the KarMeN study was registered with the German Clinical Trials Register (DRKS00004890). Details about the study can be obtained from https://www.drks.de.

Study of Awareness and Practice of Informed Consent Process Among Clinical Trial Participants and Their Motives Behind Participation

2019 ◽  
Vol 31 (8) ◽  
pp. 710-718
Author(s):  
Rajesh Ranjan ◽  
Nidhi B. Agarwal ◽  
Prem Kapur ◽  
Amit Marwah ◽  
Rizwana Parveen
Keyword(s):  
Clinical Trials ◽  
Informed Consent ◽  
Human Subjects ◽  
Cross Sectional Study ◽  
Informed Consent Process ◽  
Consent Process ◽  
Cross Sectional ◽  
Contract Research ◽  
Research Organizations ◽  
Informed Consent Document

Process to obtain informed consent is an essential component in research involving human subjects. However, much is not known about the level of awareness participants have about optimal consenting process and the motives that drive their participation in the trials. A cross-sectional study was conducted among volunteers who had been participating in clinical trials in contract research organizations of Delhi. Validated questionnaires were used to assess their knowledge, attitude, and practice of informed consent process. Most of the volunteers, 226 (56.5%), had participated in 1 to 3 clinical trials. Majority (54%) were unaware about any informed consent document. None of them were aware of their right of profession competence, privacy and integrity, transparency, nonexploitation, and nonusage of their biological samples. Effective implementation of principles of informed consenting is largely lacking among contract research organizations in Delhi, India. This could potentially cause risk to the participants.

scholarly journals A Cross-sectional Study on Zoonotic and Reverse Zoonotic Transmission of Tuberculosis in Central Ethiopia

2020 ◽  
Author(s):  
Tefera Woldemariam ◽  
Gezahegne Mamo ◽  
Aboma Zewude ◽  
Mahlet Chanyalew ◽  
Temesgen Mohammed ◽  
...  
Keyword(s):  
Rural Communities ◽  
Tandem Repeats ◽  
Human Subjects ◽  
Cross Sectional Study ◽  
Zoonotic Transmission ◽  
Sectional Study ◽  
Cross Sectional ◽  
Central Ethiopia ◽  
Low Culture

Abstract Background: The zoonotic transmission of tuberculosis (TB) from cattle to humans has long been recognized while its reverse zoonotic transmission from humans to animals has recently been reported. The socioeconomic situations of the rural communities of Ethiopia are conducive for the zoonotic and reverse zoonotic transmission of TB between cattle and human. The objective of this study was to investigate the zoonotic and reverse zoonotic transmission TB between humans and cattle central Ethiopia.Methods: To achieve this objective a cross-sectional study was conducted on 1896 cattle slaughtered in two abattoirs and 392 TB suspicious human subjects visiting health institutions for treatment. Post mortem examination, mycobacteriological culture, and spoligotyping were used for the study. In addition, the Spoligotype International Types and VNTR (variable number of DNA tandem repeats) International Types (SITVIT2) database and the online “Run TB-Lineage” were used to identify SIT and lineages of the human and cattle isolates.Results: Gross TB lesion was detected in 4.2% (80/1896) the slaughtered cattle and predominantly (52.5%) found in the thoracic cavity. But culture positivity was only 26.3% (21/80) in suspicious lesions. Of the 21 cattle isolates, 12 (57.2%) were M. bovis while the remaining nine (42.8%) were M. tuberculosis. SIT50, SIT118 and SIT1318 were isolated from both humans and cattle. Similar to the low culture yield in cattle tissues, only 22% (86/392) the sputa from TB suspicious humans were culture positive. These 86 human isolates were classified into 81 M. tuberculosis, three M. africanum and two M. bovis by spoligotyping. The two human M. bovis isolates had the pattern of SB1443, which was not isolated from cattle in this study.Conclusion: The zoonotic and reverse zoonotic transmissions of TB were confirmed in Ethiopia by the isolation of two M. bovis from human and isolation of nine M. tuberculosis from cattle, which suggested higher role of M. tuberculosis in cattle compared to the role of M. bovis in humans.

Autonomic mechanisms of training bradycardia: beta-adrenergic receptors in humans

1981 ◽  
Vol 51 (5) ◽  
pp. 1232-1237 ◽  
Author(s):  
R. S. Williams ◽  
R. S. Eden ◽  
M. E. Moll ◽  
R. M. Lester ◽  
A. G. Wallace
Keyword(s):  
Heart Rate ◽  
Physical Training ◽  
Adrenergic Receptors ◽  
Human Subjects ◽  
Sinus Node ◽  
Cross Sectional Study ◽  
Beta Adrenergic Receptors ◽  
Cross Sectional ◽  
Beta Adrenergic ◽  
Marathon Runners

To address the autonomic mechanisms underlying the bradycardia of physical training in human subjects, we performed a cross-sectional study comparing the heart-rate responses to graded doses of isoproterenol in 7 elite marathon runners and 7 age-matched controls, and a longitudinal study in 12 normal volunteers of the effects of 6 wk of intense physical training on lymphocyte beta-adrenergic receptors identified by l-[3H]dihydroalprenolol. We observed no significant differences between marathoners and controls in the dose of isoproterenol that produced a 25-beat/min increment in heart rate, either in the absence (1.9 +/- 0.6 vs. 2.5 +/- 0.6 microgram; P, 0.509) or in the presence of cholinergic blockade (4.4 +/- 1.3 vs. 3.1 +/- 0.4 microgram: P, 0.320). Likewise, we observed no effects of physical training on lymphocyte beta-adrenergic receptors in terms of receptors number (53 +/- 11 vs. 56 +/- 10 fmol/mg protein) or receptor affinity (Kd 4.0 +/- 0.7 vs. 3.6 +/- 0.7 nM) (P, 0.9178). Although our data cannot exclude reduced chronotropic sensitivity to catecholamines as contributing to lowered heart rate in some highly conditioned individuals, these results are consistent with the hypothesis that altered neuronal input to the sinus node is usually a more important mechanism of training bradycardia.

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