scholarly journals Utility of quantitative apparent diffusion coefficient measurements and normalized apparent diffusion coefficient ratios in the diagnosis of clinically significant peripheral zone prostate cancer

2018 ◽  
pp. 20180091 ◽  
Author(s):  
Tan B Nguyen ◽  
Alexander Ushinsky ◽  
Albert Yang ◽  
Michael Nguyentat ◽  
Sara Fardin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Peripheral Zone ◽  
Apparent Diffusion ◽  
Clinically Significant

scholarly journals Interpatient Variation in Normal Peripheral Zone Apparent Diffusion Coefficient: Effect on the Prediction of Prostate Cancer Aggressiveness

Radiology ◽  
2012 ◽  
Vol 265 (1) ◽  
pp. 260-266 ◽  
Author(s):  
Geert J. S. Litjens ◽  
Thomas Hambrock ◽  
Christina Hulsbergen–van de Kaa ◽  
Jelle O. Barentsz ◽  
Henkjan J. Huisman
Keyword(s):  
Prostate Cancer ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Peripheral Zone ◽  
Cancer Aggressiveness ◽  
Apparent Diffusion ◽  
Interpatient Variation

scholarly journals Multiparametric MRI Apparent Diffusion Coefficient (ADC) Accuracy in Diagnosing Clinically Significant Prostate Cancer

In Vivo ◽  
2017 ◽  
Vol 31 (3) ◽  
pp. 415-418 ◽  
Author(s):  
PIETRO PEPE ◽  
DAVIDE D’URSO ◽  
ANTONIO GARUFI ◽  
GIANDOMENICO PRIOLO ◽  
MICHELE PENNISI ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Multiparametric Mri ◽  
Apparent Diffusion ◽  
Clinically Significant

scholarly journals THE ROLE OF THE APPARENT DIFFUSION COEFFICIENT OF THE BIPARAMETRIC MRI AS AN IMAGING MARKER OF PROSTATE CANCER

2021 ◽  
Vol 26 ◽  
pp. 541-553
Author(s):  
Yu. Mytsyk ◽  
◽  
A. Borzhiyevskyy ◽  
Yu. Kobilnyk ◽  
I. Dutka ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Dynamic Contrast Enhancement ◽  
Mean Values ◽  
Apparent Diffusion ◽  
Key Words Prostate ◽  
Clinically Significant ◽  
Common Malignancy

Prostate cancer (PCa) is the most common malignancy in men. The role of the apparent diffusion coefficient (ADC) of biparametric MRI (biMRI) which is a study without the use of dynamic contrast enhancement (DCE), in detection of PCa is still not comprehensively investigated. Objective. The goal of the study was to assess the role of ADC of biMRI as an imaging marker of clinically significant PCa Materials and methods. The study involved 78 men suspected of having PCa. All patients underwent a comprehensive clinical examination, which included multiparametric MRI of the prostate, a component of which was biMRI. The MRI data was evaluated according to the PI-RADS system version 2.1. Results. The distribution of patients according to the PI-RADS system was as follows: 1 point – 9 (11.54 %) patients, 2 points – 12 (15.38 %) patients, 3 points – 25 (32.05 %) patients, 4 points – 19 (24.36 %) patients and 5 points – 13 (16.67 %) patients. In a subgroup of patients with 5 points, clinically significant PCa was detected in 100 % of cases. In the subgroup of patients with tumors of 4 points clinically significant PCa was diagnosed in 16 of 19 (84.21 %) cases, and in 3 (15.79 %) patients – clinically insignificant tumor. In the subgroup of patients with 3 points, clinically significant PCa was diagnosed in 11 of 25 (44.0 %) cases, in 8 (32.0 %) patients – clinically insignificant tumor and in 6 (24.0 %) patients – benign prostatic hyperplasia. PCa with a score of ≥ 7 on the Gleason scale showed significantly lower mean values of ADC of the diffusion-weighted MRI images compared to tumors with a score of < 7 on the Gleason scale: (0.86 ± 0.07) x 10-3 mm2/s vs (1.08 ± 0.04) x 10-3 mm2/s (р < 0.05). Conclusions. The obtained results testify to the high informativeness of biMRI in the diagnosis of prostate cancer. The use of ADC allowed to differentiate clinically significant and insignificant variants of the tumor, as well as benign changes in prostate tissues and can be considered as a potential imaging marker of PCa. Key words: prostate cancer, diagnosis, biparametric MRI, marker, apparent diffusion coefficient, PI-RADS.

scholarly journals Discrimination between clinical significant and insignificant prostate cancer with Apparent diffusion coefficient – A systematic review and meta analysis

2020 ◽  
Author(s):  
Hans-Jonas Meyer ◽  
Andreas Wienke ◽  
Alexey Surov
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Gleason Score ◽  
Adc Value ◽  
Apparent Diffusion ◽  
Adc Values ◽  
Clinically Significant ◽  
Insignificant Prostate Cancer

Abstract Background Multiparametric MRI has become a corner stone in diagnosis of prostate cancer (PC). Diffusion weighted imaging and the apparent diffusion coefficient (ADC) can be used to reflect tumor microstructure. The present analysis sought to compare ADC values of clinically insignificant with clinical significant PC based upon a large patient sample. Methods MEDLINE library and SCOPUS databases were screened for the associations between ADC and Gleason score in PC up to May 2019. The primary endpoint of the systematic review was the ADC value of PC groups according to Gleason score. In total 27 studies were suitable for the analysis and included into the present study. The included studies comprised a total of 1633 lesions. Results Clinically relevant PCs (Gleason score 7 and higher) were diagnosed in 1078 cases (66.0%) and insignificant PCs (Gleason score 5 and 6) in 555 cases (34.0%). The pooled mean ADC value of the clinically significant PC was 0.86x10-3 mm2/s [95% CI 0.83-0.90] and the pooled mean value of insignificant PC was 1.1 x10-3 mm2/s [95% CI 1.03-1.18]. Clinical significant PC showed lower ADC values compared to non-significant PC. The pooled ADC values of clinically insignificant PCs were no lower than 0.75 ×10-3 mm2/s. This value may be proposed as a threshold for distinguishing clinically significant from insignificant PCs. Conclusions We evaluated the published literature comparing clinical insignificant with clinically prostate cancer in regard of the Apparent diffusion coefficient values derived from magnetic resonance imaging. We identified that the clinically insignificant prostate cancer have lower ADC values than clinically significant, which may aid in tumor noninvasive tumor characterization in clinical routine.

Apparent Diffusion Coefficient (ADC) Ratio Versus Conventional ADC for Detecting Clinically Significant Prostate Cancer With 3-T MRI

2019 ◽  
Vol 213 (3) ◽  
pp. W134-W142 ◽  
Author(s):  
Amirhossein Mohammadian Bajgiran ◽  
Sohrab Afshari Mirak ◽  
Kyunghyun Sung ◽  
Anthony E. Sisk ◽  
Robert E. Reiter ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Apparent Diffusion ◽  
Clinically Significant ◽  
Ratio Versus
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