scholarly journals 123I-MIBG myocardial scintigraphy for the evaluation of Lewy body disease: are delayed images essential? Is visual assessment useful?

2016 ◽  
Vol 89 (1064) ◽  
pp. 20160144 ◽  
Author(s):  
Fumi Sakamoto ◽  
Shinya Shiraishi ◽  
Noriko Tsuda ◽  
Koji Ogasawara ◽  
Morikatsu Yoshida ◽  
...  
Keyword(s):  
Lewy Body ◽  
Lewy Body Disease ◽  
Visual Assessment ◽  
Myocardial Scintigraphy

The Role of 123I-Metaiodobenzylguanidine Myocardial Scintigraphy in the Diagnosis of Lewy Body Disease in Patients with Dementia in a Memory Clinic

2006 ◽  
Vol 22 (5-6) ◽  
pp. 379-384 ◽  
Author(s):  
Haruo Hanyu ◽  
Soichiro Shimizu ◽  
Kentaro Hirao ◽  
Hirofumi Sakurai ◽  
Toshihiko Iwamoto ◽  
...  
Keyword(s):  
Lewy Body ◽  
Lewy Body Disease ◽  
Myocardial Scintigraphy ◽  
Memory Clinic

scholarly journals Dynamic planar scintigraphy for the rapid kinetic measurement of myocardial 123I-MIBG turnover can identify Lewy body disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yoshitaka Kumakura ◽  
Yuji Shimizu ◽  
Masatsugu Hariu ◽  
Ken-ichi Ichikawa ◽  
Norihito Yoshida ◽  
...  
Keyword(s):  
Lewy Body ◽  
Lewy Bodies ◽  
Lewy Body Disease ◽  
Myocardial Scintigraphy ◽  
Turnover Rates ◽  
Planar Imaging ◽  
Time Activity ◽  
Model Based ◽  
Potential Association ◽  
Fractional Distribution

Abstract Background Using two static scans for 123I-meta-iodobenzyl-guanidine (123I-MIBG) myocardial scintigraphy ignores the dynamic response from vesicular trapping in nerve terminals. Moreover, the long pause between scans is impractical for patients with Lewy body diseases (LBDs). Here, we optimized indices that capture norepinephrine kinetics, tested their diagnostic performance, and determined the differences in 123I-MIBG performance among disease groups. Methods We developed a new 30-min protocol for 123I-MIBG dynamic planar imaging for suspected LBD patients. Pharmacokinetic modelling of time-activity curves (TACs) was used to calculate three new indices: unidirectional uptake of 123I-MIBG to vesicular trapping (iUp), rate of myocardial 123I-MIBG loss (iLoss), and non-specific fractional distribution of 123I-MIBG in the interstitial space. We compared the performance of the new and existing indices with regard to discrimination of patients with or without LBDs. Subgroup analysis was performed to examine differences in 123I-MIBG turnover between patients in a dementia with Lewy bodies (DLB) group and two Parkinson’s disease (PD) groups, one with and the other without REM sleep behaviour disorder (RBD). Results iLoss was highly discriminative, particularly for patients with low myocardial 123I-MIBG trapping, and the new indices outperformed existing ones. ROC analysis revealed that the AUC of iLoss (0.903) was significantly higher than that of early HMR (0.863), while comparable to that of delayed HMR (0.892). The RBD-positive PD group and the DLB group had higher turnover rates than the RBD-negative PD group, indicating a potential association between prognosis and iLoss. Conclusion 123I-MIBG turnover can be quantified in 30 min using a three-parameter model based on 123I-MIBG TACs. The discriminatory performance of the new model-based indices might help explain the neurotoxicity or neurodegeneration that occurs in LBD patients.

A Review of Lewy Body Disease

1998 ◽  
Vol 3 (1) ◽  
pp. 13-19
Author(s):  
Denise A. Drumm ◽  
D. Larry Sparks
Keyword(s):  
Lewy Body ◽  
Lewy Body Disease

Lewy Body Disease

2002 ◽  
Vol 59 (6) ◽  
pp. 1043-1043
Author(s):  
D. E. Riley
Keyword(s):  
Lewy Body ◽  
Lewy Body Disease

scholarly journals Structural connectivity networks in Alzheimer’s disease and Lewy body disease

2021 ◽  
Author(s):  
Kyoungwon Baik ◽  
Jin‐Ju Yang ◽  
Jin Ho Jung ◽  
Yang Hyun Lee ◽  
Seok Jong Chung ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Structural Connectivity ◽  
Lewy Body Disease

scholarly journals Comparison of the diagnostic performance of H/M ratio between early and delayed phases for Lewy body disease

2015 ◽  
Vol 36 (5) ◽  
pp. 477-480
Author(s):  
Yasuki Maruyama ◽  
Takayuki Yamada ◽  
Kenji Murakami ◽  
Reiko Kumano
Keyword(s):  
Lewy Body ◽  
Diagnostic Performance ◽  
Lewy Body Disease
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