scholarly journals Improving target dose coverage and organ-at-risk sparing in intensity-modulated radiotherapy of advanced laryngeal cancer by a simple optimization technique

2015 ◽  
Vol 88 (1046) ◽  
pp. 20140654 ◽  
Author(s):  
J-Y Lu ◽  
L-L Wu ◽  
J-Y Zhang ◽  
J Zheng ◽  
M L-M Cheung ◽  
...  
Keyword(s):  
At Risk ◽  
Laryngeal Cancer ◽  
Optimization Technique ◽  
Intensity Modulated Radiotherapy ◽  
Target Dose ◽  
Intensity Modulated ◽  
Organ At Risk

scholarly journals Impact of Geometric Uncertainties on Dose Distribution During Intensity Modulated Radiotherapy of Head-and-neck Cancer: The Need for a Planning Target Volume and A Planning Organ-at-Risk Volume

2006 ◽  
Vol 13 (3) ◽  
pp. 108-115 ◽  
Author(s):  
O. Ballivy ◽  
W. Parker ◽  
T. Vuong ◽  
G. Shenouda ◽  
H. Patrocinio
Keyword(s):  
Spinal Cord ◽  
At Risk ◽  
Neck Cancer ◽  
Intensity Modulated Radiotherapy ◽  
Target Volume ◽  
Ct Scans ◽  
Target Coverage ◽  
Geometric Uncertainties ◽  
Intensity Modulated ◽  
Organ At Risk

We assessed the effect of geometric uncertainties on target coverage and on dose to the organs at risk (OARS) during intensity-modulated radiotherapy (IMRT) for head-and-neck cancer, and we estimated the required margins for the planning target volume (PTV) and the planning organ-at-risk volume (PRV). For eight headand- neck cancer patients, we generated IMRT plans with localization uncertainty margins of 0 mm, 2.5 mm, and 5.0 mm. The beam intensities were then applied on repeat computed tomography (CT) scans obtained weekly during treatment, and dose distributions were recalculated. The dose–volume histogram analysis for the repeat CT scans showed that target coverage was adequate (V100 ≥ 95%) for only 12.5% of the gross tumour volumes, 54.3% of the upper-neck clinical target volumes (CTVS), and 27.4% of the lower-neck CTVS when no margins were added for PTV. The use of 2.5-mm and 5.0-mm margins significantly improved target coverage, but the mean dose to the contralateral parotid increased from 25.9 Gy to 29.2 Gy. Maximum dose to the spinal cord was above limit in 57.7%, 34.6%, and 15.4% of cases when 0-mm, 2.5-mm, and 5.0-mm margins (respectively) were used for PRV. Significant deviations from the prescribed dose can occur during IMRT treatment delivery for headand- neck cancer. The use of 2.5-mm to 5.0-mm margins for PTV and PRV greatly reduces the risk of underdosing targets and of overdosing the spinal cord.

scholarly journals Improving Target Coverage and Organ-at-Risk Sparing in Intensity-Modulated Radiotherapy for Cervical Oesophageal Cancer Using a Simple Optimisation Method

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0121679 ◽  
Author(s):  
Jia-Yang Lu ◽  
Michael Lok-Man Cheung ◽  
Bao-Tian Huang ◽  
Li-Li Wu ◽  
Wen-Jia Xie ◽  
...  
Keyword(s):  
At Risk ◽  
Oesophageal Cancer ◽  
Intensity Modulated Radiotherapy ◽  
Target Coverage ◽  
Intensity Modulated ◽  
Organ At Risk
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