scholarly journals Meta-analysis of CT-guided transthoracic needle biopsy for the evaluation of the ground-glass opacity pulmonary lesions

2014 ◽  
Vol 87 (1042) ◽  
pp. 20140276 ◽  
Author(s):  
J-S Yang ◽  
Y-M Liu ◽  
Y-M Mao ◽  
J-H Yuan ◽  
W-Q Yu ◽  
...  
Keyword(s):  
Needle Biopsy ◽  
Meta Analysis ◽  
Ground Glass Opacity ◽  
Ground Glass ◽  
Transthoracic Needle Biopsy ◽  
Ct Guided ◽  
Pulmonary Lesions

scholarly journals Diagnostic Accuracy of CT-Guided Core Biopsy of Ground-Glass Opacity Pulmonary Lesions

2008 ◽  
Vol 190 (1) ◽  
pp. 234-239 ◽  
Author(s):  
Tae Jung Kim ◽  
Jae-Ho Lee ◽  
Choon-Taek Lee ◽  
Sang Hoon Jheon ◽  
Sook Whan Sung ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Core Biopsy ◽  
Ground Glass Opacity ◽  
Ground Glass ◽  
Ct Guided ◽  
Pulmonary Lesions

scholarly journals CT-guided transthoracic needle biopsy of pulmonary lesions: comparison between the cutting needle and aspiration needle

2020 ◽  
pp. 20190930
Author(s):  
Zhen-guo Huang ◽  
Hong-liang Sun ◽  
Cun-li Wang ◽  
Bao-xiang Gao ◽  
He Chen ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Complication Rate ◽  
Needle Biopsy ◽  
Final Diagnosis ◽  
Benign Lesions ◽  
Transthoracic Needle Biopsy ◽  
Ct Guided ◽  
Pulmonary Lesions ◽  
Severe Hemorrhage ◽  
Cutting Needle

Objectives: To compare CT-guided transthoracic cutting needle biopsy (TCNB) with transthoracic aspiration needle biopsy (TANB) for pulmonary lesions with respect to the diagnostic accuracy and complication rate. Methods: Of the 859 cases that underwent consecutive CT-guided biopsy of pulmonary lesions, 713 cases confirmed by surgical pathology or clinical follow-up were enrolled. Of these, the first consecutive 275 cases underwent TANB, and the remaining 438 received TCNB. The final diagnosis determined the accuracy of biopsy. Based on the post-biopsy CT and clinical medical records, the presence or absence of biopsy-related complications was determined. The χ2 test was used to compare the differences between TCNB and TANB in terms of diagnostic accuracy and complication rate. Results: Among the 713 biopsy lesions, the final diagnosis was malignant in 411 cases and benign in 302 cases. As compared to TANB, the diagnostic accuracy of TCNB (98.9% vs 93.8%, χ2 = 14.35, p < 0.01), sensitivity to malignant lesions (97.8% vs 90.6%, χ2 = 10.58, p < 0.01), negative predictive value (97.6% vs 84.8%, χ2 = 19.03, p < 0.01), and specific diagnostic rate for benign lesions (73.4% vs 57.9%, χ2 = 7.29, p < 0.01) were improved. On the other hand, a statistical difference was detected between TCNB and TANB with respect to the incidence of pneumothorax (20.6% vs 13.1%, χ2 = 6.46, p = 0.01), hemorrhage (32.2% vs 13.1%, χ2 = 33.03, p < 0.01), and hemoptysis (8.2% vs 3.3%, χ2 = 6.87, p < 0.01). One patient died just several minutes after TCNB due to severe hemorrhage with hemoptysis. Conclusions: Compared to TANB, CT-guided TCNB improves the diagnostic accuracy of pulmonary lesions, but complication rate increases significantly. Advances in knowledge: In general, TCNB should be recommended, especially for highly suspicious benign lesions. For patients with small lesions adjacent to vessels or vessels within the lesion, TANB should be considered.

scholarly journals Computed Tomography-Guided Transthoracic Needle Biopsy: Predictors for Diagnostic Failure and Tissue Adequacy for Molecular Testing

2021 ◽  
Vol 8 ◽  
Author(s):  
Chia-Ying Lin ◽  
Chao-Chun Chang ◽  
Chang-Yao Chu ◽  
Li-Ting Huang ◽  
Ta-Jung Chung ◽  
...  
Keyword(s):  
Needle Biopsy ◽  
Lung Tumor ◽  
Ground Glass Opacity ◽  
Molecular Testing ◽  
Slice Thickness ◽  
Transthoracic Needle Biopsy ◽  
Ct Guided ◽  
Factors Influencing ◽  
Coaxial Needle ◽  
Younger Age

Background: Adequate and representative tissue from lung tumor is important in the era of precision medicine. The aim of this study is to identify detailed procedure-related variables and factors influencing diagnostic success and tissue adequacy for molecular testing in CT-guided TTNB.Methods: Consecutive patients undergoing CT-guided TTNB were retrospectively enrolled between January 2013 and May 2020. Multivariate analysis was performed for predictors for diagnostic accuracy and tissue adequacy for molecular testing. Logistic regression was used to identify risk factors for procedure-related complications.Results: A total of 2,556 patients undergoing CT-guided TTNB were enrolled and overall success rate was 91.5% (2,338/2,556). For lung nodules ≤3 cm, predictors for diagnostic success included coaxial needle use [OR = 0.34 (0.16–0.71), p = 0.004], CT scan slice thickness of 2.5 mm [OR = 0.42 (0.15–0.82), p = 0.011] and additional prefire imaging [OR = 0.31 (0.14–0.68), p = 0.004]. For lung tumor &gt;3 cm, ground glass opacity part more than 50% [OR = 7.53 (2.81–20.23), p &lt; 0.001] or presence of obstructive pneumonitis [OR = 2.31 (1.53–3.48), p &lt; 0.001] had higher risk of diagnostic failure. For tissue adequacy, tissue submitted in two cassettes (98.9 vs. 94.9%, p = 0.027) was a positive predictor; while male (5.7 vs. 2.5%, p = 0.032), younger age (56.61 ± 11.64 vs. 65.82 ± 11.98, p &lt; 0.001), and screening for clinical trial (18.5 vs. 0.7%, p &lt; 0.001) were negative predictors.Conclusions: Using a coaxial needle, with thin CT slice thickness (2.5 mm), and obtaining additional prefire imaging improved diagnostic success, while obtaining more than two tissue cores and submitting in two cassettes improved tissue adequacy for molecular testing.

Sign in / Sign up

Export Citation Format

Share Document