scholarly journals Moyamoya disease in pregnancy: maintenance of maternal blood pressure

2011 ◽  
Vol 5 (1) ◽  
pp. 32-34 ◽  
Author(s):  
Helen L Barrett ◽  
Karin Lust ◽  
Narelle Fagermo ◽  
Leonie K Callaway ◽  
Lee Minuzzo

Moyamoya disease is a rare cerebrovascular occlusive disorder characterized by stenosis in the circle of Willis with the development of a compensatory circulation. It has been associated with significant morbidity in pregnancy including intracranial haemorrhage, ischaemic stroke and epilepsy. We present the case of a 26-year-old woman with a previous diagnosis of moyamoya vasculopathy with bilateral superficial temporal to middle cerebral artery bypass grafting. During the second trimester, she developed significant neurological symptoms related to postural hypotension in the presence of a stenosis of the right-sided graft. The hypotension was treated with fludrocortisone therapy with improvement in blood pressure and symptoms. Moyamoya vasculopathy poses unique challenges to obstetric care. This is the first report of use of fludrocortisone for maintenance of blood pressure during pregnancy in this condition.

1996 ◽  
Vol 15 (2) ◽  
pp. 219-228
Author(s):  
Herbert Valensise ◽  
Raffaele Conforti ◽  
Dario Cipriani ◽  
Donatella Dell'anna ◽  
Alessandra Petruio ◽  
...  

1990 ◽  
Vol 78 (1) ◽  
pp. 95-100 ◽  
Author(s):  
Ph. Loquet ◽  
F. Broughton Pipkin ◽  
E. M. Symonds ◽  
P. C. Rubin

1. The effect of doubling doses of angiotensin II on maternal systemic blood pressure and arcuate and fetal umbilical artery Doppler velocity profiles has been investigated in 10 women in first- and 10 in second-trimester pregnancy. Ten non-pregnant women were also studied. 2. A progressive decrease in the pressor response to angiotensin II in early pregnancy as previously described was confirmed. 3. Angiotensin II induced a significant dose-dependent increase in the pulsatility index (a measure of downstream resistance) in the umbilical artery in both first- and second-trimester patients. There was an apparent increase in the threshold response of the pulsatility index to angiotensin II in the umbilical artery as pregnancy progressed. There was also a significant correlation between changes in maternal systolic or diastolic pressure and change in umbilical artery pulsatility index, but this did not differ between the two trimesters. This suggests that the increase in pulsatility index is related to blood pressure rather than angiotensin II. This is consistent with reports that angiotensin II does not cross the haemo-monochorial placenta. 4. Basal pulsatility index in the arcuate artery fell with increasing gestation. There was a significant inverse association between the evoked change in maternal systemic blood pressure and the change in arcuate artery pulsatility index, suggesting local vasodilatation. 5. We conclude that acutely increasing maternal blood pressure leads to increased vascular resistance on the fetal side of the circulation.


2020 ◽  
Vol 33 (5) ◽  
pp. 686-697 ◽  
Author(s):  
A. U. Courtney ◽  
E. C. O’Brien ◽  
R. K. Crowley ◽  
A. A. Geraghty ◽  
M. B. Brady ◽  
...  

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200159 ◽  
Author(s):  
Ka Ying Bonnie Ng ◽  
Nigel A. B. Simpson ◽  
Janet E. Cade ◽  
Darren C. Greenwood ◽  
Harry J. Mcardle ◽  
...  

2015 ◽  
Vol 43 (6) ◽  
Author(s):  
Tamika Royal-Thomas ◽  
Daniel McGee ◽  
Debajyoti Sinha ◽  
Clive Osmond ◽  
Terrence Forrester

AbstractThis article looks at the association of maternal blood pressure with the blood pressure of the offspring from birth to childhood. The Barker hypothesis states that maternal and “


BMJ ◽  
2004 ◽  
Vol 329 (7478) ◽  
pp. 1312 ◽  
Author(s):  
Philip J Steer ◽  
Mark P Little ◽  
Tina Kold-Jensen ◽  
Jean Chapple ◽  
Paul Elliott

Hypertension ◽  
2016 ◽  
Vol 68 (6) ◽  
pp. 1459-1466 ◽  
Author(s):  
Clive J. Petry ◽  
Nuria Sanz Marcos ◽  
Gracielle Pimentel ◽  
M. Geoffrey Hayes ◽  
Michael Nodzenski ◽  
...  

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