scholarly journals The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia–reperfusion injury

2011 ◽  
Vol 45 (3) ◽  
pp. 160-166 ◽  
Author(s):  
Kirsten M Smeele ◽  
Leontien H ter Horst ◽  
Anneke Koeman ◽  
Sami Heikkinen ◽  
Markku Laakso ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Reperfusion Injury ◽  
Low Flow ◽  
Hexokinase Ii ◽  
Ischaemia Reperfusion Injury ◽  
Cardiac Ischaemia ◽  
Ischaemia Reperfusion

Timing of Administration of Dexamethasone or the Nitric Oxide Synthase Inhibitor, Nitro-l-Arginine Methyl Ester, is Critical for Effective Treatment of Ischaemia-Reperfusion Injury to Rat Skeletal Muscle

1997 ◽  
Vol 93 (2) ◽  
pp. 167-174 ◽  
Author(s):  
Baimeng Zhang ◽  
Kenneth R. Knight ◽  
Bruce Dowsing ◽  
Elizabeth Guida ◽  
Long H. Phan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Methyl Ester ◽  
Nitric Oxide Synthase ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Nos Inhibitors ◽  
Oxide Synthase ◽  
Inducible Nos

1. The effects of the nitric oxide synthase (NOS) inhibitors, NG-nitro-l-arginine-methyl ester (l-NAME), nitroiminoethyl-l-ornithine and S-methylisothiourea on skeletal muscle survival following 2 h of tourniquet ischaemia and 24 h of reperfusion were compared with those of the antiinflammatory steroid, dexamethasone. 2. Administration of each of the NOS inhibitors or dexamethasone 30 min before reperfusion reduced the degree of skeletal muscle necrosis 24 h after reperfusion. 3. The influence of timing of drug administration was investigated. l-NAME administered 30 min before reperfusion, at 3 h after reperfusion, but not thereafter, significantly improved muscle survival compared with saline-treated controls. Dexamethasone administered 30 min before, or at 3 or 8 h after reperfusion, but not at 16 h, significantly improved muscle survival, but neither agent had protective effects when administered before ischaemia. 4. After 8 h of reperfusion of ischaemic skeletal muscle, cell-free homogenates contained Ca2+-independent (inducible) NOS activity which was reduced in dexamethasone-treated (2.5 mg/kg) rats. Furthermore, inducible NOS mRNA levels, as detected by reverse transcriptase-PCR, were increased after 8 h of reperfusion in saline, but not in dexamethasone-treated rats. 5. These data suggest a significant deleterious effect of endogenous NO which may be restricted to the first 3 h of the reperfusion phase of ischaemia-reperfusion injury, and raise the possibility of effective treatment of incipient reperfusion injury, even after several hours of reperfusion.

scholarly journals The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0152681 ◽  
Author(s):  
Peng Zhang ◽  
James C. Weaver ◽  
Gang Chen ◽  
Julia Beretov ◽  
Tatsuya Atsumi ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Cardiac Ischaemia ◽  
Glycoprotein I ◽  
Ischaemia Reperfusion ◽  
Beta 2 ◽  
Natural Igm

alpha-Tocopherol Pretreatment Reduces Ischaemia/Reperfusion Injury in Rabbit Skeletal Muscle

2002 ◽  
Vol 34 (2) ◽  
pp. 90-94 ◽  
Author(s):  
C. Neumayer ◽  
J. Nanobashvili ◽  
A. Fugl ◽  
R. Blumer ◽  
A. Punz ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Reperfusion Injury ◽  
Rabbit Skeletal Muscle ◽  
Alpha Tocopherol ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

scholarly journals Danshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosis via activation of mTOR signalling

2016 ◽  
Vol 20 (10) ◽  
pp. 1908-1919 ◽  
Author(s):  
Guanwei Fan ◽  
Jiahui Yu ◽  
Patrick Fordjour Asare ◽  
Lingyan Wang ◽  
Han Zhang ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Cardiac Ischaemia ◽  
Ischaemia Reperfusion ◽  
Mtor Signalling

Activated protein C attenuates skeletal muscle ischaemia reperfusion injury.

2003 ◽  
Vol 114 (2) ◽  
pp. 248
Author(s):  
J.P. Dillon ◽  
A.J. Laing ◽  
R.C. Cahill ◽  
G.C. O’Brien ◽  
J.H. Wang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Reperfusion Injury ◽  
Protein C ◽  
Activated Protein C ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Muscle Ischaemia
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