Endoplasmic reticulum stress and C/EBP homologous protein-induced Bax translocation are involved in angiotensin II-induced apoptosis in cultured neonatal rat cardiomyocytes

2012 ◽  
Vol 237 (11) ◽  
pp. 1341-1349 ◽  
Author(s):  
Xiao-Jing Zou ◽  
Le Yang ◽  
Shang-Long Yao
Keyword(s):  
Endoplasmic Reticulum ◽  
Angiotensin Ii ◽  
Endoplasmic Reticulum Stress ◽  
Neonatal Rat ◽  
Rat Cardiomyocytes ◽  
Homologous Protein ◽  
Neonatal Rat Cardiomyocytes ◽  
Induced Apoptosis

scholarly journals e0140 Endoplasmic reticulum stress induced-apoptotic model by tunicamycin in cultured neonatal rat cardiomyocytes

Heart ◽  
2010 ◽  
Vol 96 (Suppl 3) ◽  
pp. A45-A45
Author(s):  
S. Ming-Zhi ◽  
Z. Y.-l. Zhao ◽  
Z. Meng ◽  
D. Ming-ge ◽  
W. Xiaoming
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Neonatal Rat ◽  
Rat Cardiomyocytes ◽  
Neonatal Rat Cardiomyocytes

Nitric oxide signaling in stretch‐induced apoptosis of neonatal rat cardiomyocytes

2006 ◽  
Vol 20 (11) ◽  
pp. 1883-1885 ◽  
Author(s):  
Xudong Liao ◽  
Jun‐Ming Liu ◽  
Lei Du ◽  
Aihui Tang ◽  
Yingli Shang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Neonatal Rat ◽  
Rat Cardiomyocytes ◽  
Nitric Oxide Signaling ◽  
Neonatal Rat Cardiomyocytes ◽  
Induced Apoptosis

Cysteinyl leukotriene-dependent [Ca2+]iresponses to angiotensin II in cardiomyocytes

2003 ◽  
Vol 284 (4) ◽  
pp. H1269-H1276 ◽  
Author(s):  
Pinggang Liu ◽  
Derek A. Misurski ◽  
Venkat Gopalakrishnan
Keyword(s):  
Angiotensin Ii ◽  
Single Cells ◽  
Receptor Activation ◽  
Neonatal Rat ◽  
Ang Ii ◽  
Rat Cardiomyocytes ◽  
Endothelin 1 ◽  
Neonatal Rat Cardiomyocytes ◽  
Cysteinyl Leukotriene

With the use of fura 2 measurements in multiple and single cells, we examined whether cysteinyl leukotrienes (CysLT) mediate angiotensin II (ANG II)-evoked increases in cytosolic free Ca2+ concentration ([Ca2+]i) in neonatal rat cardiomyocytes. ANG II-evoked CysLT release peaked at 1 min. The angiotensin type 1 (AT1) antagonist losartan, but not the AT2antagonist PD-123319, attenuated the elevations in [Ca2+]i and CysLT levels evoked by ANG II. Vasopressin and endothelin-1 increased [Ca2+]i but not CysLT levels. The 5-lipoxygenase (5-LO) inhibitor AA-861 and the CysLT1-selective antagonist MK-571 reduced the maximal [Ca2+]i responses to ANG II but not to vasopressin and endothelin-1. While MK-571 reduced the responses to leukotriene D4 (LTD4), the dual CysLT antagonist BAY-u9773 completely blocked the [Ca2+]i elevation to both LTD4and LTC4. These data confirm that ANG II-evoked increases, but not vasopressin- and endothelin-1-evoked increases, in [Ca2+]i involve generation of the 5-lipoxygenase metabolite CysLT. The inositol (1,4,5)-trisphosphate [Ins(1,4,5)P3] antagonist 2-aminoethoxydiphenyl borate attenuated the [Ca2+]i responses to ANG II and LTD4. Thus AT1 receptor activation by ANG II is linked to CysLT-mediated Ca2+ release from Ins(1,4,5)P3-sensitive intracellular stores to augment direct ANG II-evoked Ca2+ mobilization in rat cardiomyocytes.

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