The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver disease

2011 ◽  
Vol 236 (10) ◽  
pp. 1116-1121 ◽  
Author(s):  
Jinhan He ◽  
Jung Hoon Lee ◽  
Maria Febbraio ◽  
Wen Xie
Keyword(s):  
Fatty Acid ◽  
Liver Disease ◽  
Fatty Liver ◽  
Aryl Hydrocarbon Receptor ◽  
Fatty Liver Disease ◽  
Fatty Acid Translocase ◽  
Aryl Hydrocarbon

The Role of Aryl Hydrocarbon Receptor in PCB-Induced Fatty Liver Disease in Mice

2017 ◽  
Vol 152 (5) ◽  
pp. S1108-S1109
Author(s):  
Hongxue Shi ◽  
Heather Clair ◽  
Josiah Hardesty ◽  
Jian Jin ◽  
Cameron Falkner ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Aryl Hydrocarbon Receptor ◽  
Fatty Liver Disease ◽  
Aryl Hydrocarbon

scholarly journals Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice

mSystems ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Zunji Shi ◽  
Hehua Lei ◽  
Gui Chen ◽  
Peihong Yuan ◽  
Zheng Cao ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Aryl Hydrocarbon Receptor ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Content Type ◽  
Nonalcoholic Fatty Liver ◽  
Akkermansia Muciniphila ◽  
Aryl Hydrocarbon ◽  
High Level

ABSTRACT Noncaloric artificial sweeteners (NAS) are extensively introduced into commonly consumed drinks and foods worldwide. However, data on the health effects of NAS consumption remain elusive. Saccharin and sucralose have been shown to pass through the human gastrointestinal tract without undergoing absorption and metabolism and directly encounter the gut microbiota community. Here, we aimed to identify a novel mechanism linking intestinal Akkermansia muciniphila and the aryl hydrocarbon receptor (AHR) to saccharin/sucralose-induced nonalcoholic fatty liver disease (NAFLD) in mice. Saccharin/sucralose consumption altered the gut microbial community structure, with significant depletion of A. muciniphila abundance in the cecal contents of mice, resulting in disruption of intestinal permeability and a high level of serum lipopolysaccharide, which likely contributed to systemic inflammation and caused NAFLD in mice. Saccharin/sucralose also markedly decreased microbiota-derived AHR ligands and colonic AHR expression, which are closely associated with many metabolic syndromes. Metformin or fructo-oligosaccharide supplementation significantly restored A. muciniphila and AHR ligands in sucralose-consuming mice, consequently ameliorating NAFLD. IMPORTANCE Our findings indicate that the gut-liver signaling axis contributes to saccharin/sucralose consumption-induced NAFLD. Supplementation with metformin or fructo-oligosaccharide is a potential therapeutic strategy for NAFLD treatment. In addition, we also developed a new nutritional strategy by using a natural sweetener (neohesperidin dihydrochalcone [NHDC]) as a substitute for NAS and free sugars.

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