Structural basis and sequence co-evolution analysis of the hemagglutinin protein of pandemic influenza A/H1N1 (2009) virus

2011 ◽  
Vol 236 (8) ◽  
pp. 915-925 ◽  
Author(s):  
Herman Tse ◽  
Richard Y T Kao ◽  
Wai Lan Wu ◽  
Wilian W L Lim ◽  
Honglin Chen ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Structural Basis ◽  
Evolution Analysis ◽  
Influenza A H1n1 ◽  
Hemagglutinin Protein

D225G mutation in the hemagglutinin protein found in 3 severe cases of 2009 pandemic influenza A (H1N1) in Spain

2010 ◽  
Vol 67 (2) ◽  
pp. 207-208 ◽  
Author(s):  
Andrés Antón ◽  
María Ángeles Marcos ◽  
Miguel Julián Martínez ◽  
Susana Ramón ◽  
Anna Martínez ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Influenza A H1n1 ◽  
Hemagglutinin Protein

scholarly journals Naturally Occurring Human Monoclonal Antibodies Neutralize both 1918 and 2009 Pandemic Influenza A (H1N1) Viruses

2009 ◽  
Vol 84 (6) ◽  
pp. 3127-3130 ◽  
Author(s):  
Jens C. Krause ◽  
Terrence M. Tumpey ◽  
Chelsey J. Huffman ◽  
Patricia A. McGraw ◽  
Melissa B. Pearce ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Antigenic Site ◽  
Human Monoclonal Antibodies ◽  
Influenza A H1n1 ◽  
Protein Sequence Homology ◽  
Hemagglutinin Protein

ABSTRACT The 2009 pandemic influenza A (H1N1) virus exhibits hemagglutinin protein sequence homology with the 1918 pandemic influenza virus. We found that human monoclonal antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009 hemagglutinins, a site that is hypervariable due to immune selection. These antibodies exhibited high potency against the 2009 virus in vitro, and one exerted a marked therapeutic effect in vivo.

scholarly journals Expression of Surfactant protein D (SP-D) distinguishes severe pandemic influenza A(H1N1) from COVID-19

2021 ◽  
Author(s):  
José Alberto Choreño-Parra ◽  
Luis Armando Jiménez-Álvarez ◽  
Gustavo Ramírez-Martínez ◽  
Alfredo Cruz-Lagunas ◽  
Mahima Thapa ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Alveolar Epithelium ◽  
Surfactant Protein ◽  
High Serum ◽  
Surfactant Protein D ◽  
Diagnostic Challenge ◽  
Moderate Disease ◽  
Influenza A H1n1 ◽  
Novel Biomarkers

Abstract The differentiation of influenza and COVID-19 could constitute a diagnostic challenge during the ongoing winter due to their clinical similitude. Thus, novel biomarkers that enable distinguishing both diseases are required. Here, we evaluated whether the surfactant protein D (SP-D), a collectin produced at the alveolar epithelium with known immune properties, was useful to differentiate pandemic influenza A(H1N1) from COVID-19 in critically ill patients. Our results revealed high serum SP-D levels in severe pandemic influenza but not COVID-19 patients. This finding was validated in a separate cohort of mechanically ventilated COVID-19 patients who also showed low plasma SP-D levels. However, plasma SP-D levels did not distinguish seasonal influenza from COVID-19 in mild-to-moderate disease. Finally, we found that high serum SP-D levels were associated with mortality and renal failure among severe pandemic influenza cases. Thus, our studies have identified SP-D as a unique biomarker expressed during severe pandemic influenza but not COVID-19.

scholarly journals Ultrastructural and Histopathological Studies of 2009 Pandemic Influenza A (H1N1) Virus

2010 ◽  
Vol 16 (S2) ◽  
pp. 1122-1123
Author(s):  
CS Goldsmith ◽  
MG Metcalfe ◽  
W-J Shieh ◽  
DM Blau ◽  
DC Rollin ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
H1n1 Virus ◽  
Influenza A H1n1 ◽  
Histopathological Studies

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.

scholarly journals Effects of Vaccine Program against Pandemic Influenza A(H1N1) Virus, United States, 2009–2010

2013 ◽  
Vol 19 (3) ◽  
Author(s):  
Rebekah H. Borse ◽  
Sundar S. Shrestha ◽  
Anthony E. Fiore ◽  
Charisma Y. Atkins ◽  
James A. Singleton ◽  
...  
Keyword(s):  
United States ◽  
Pandemic Influenza ◽  
Influenza A ◽  
H1n1 Virus ◽  
Influenza A H1n1
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