Early results of real-time qualitative sonoelastography in the evaluation of parotid gland masses: A study with histopathological correlation

2013 ◽  
Vol 54 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Irfan Celebi ◽  
Abdullah S Mahmutoglu
Keyword(s):  
Parotid Gland ◽  
Cell Carcinoma ◽  
Real Time ◽  
Malignant Tumors ◽  
Characteristic Curve ◽  
Kappa Statistic ◽  
Benign Tumors ◽  
Low Grade ◽  
Primary Role ◽  
Early Results

Background Sonoelastography has been used to differentiate malignant from benign lesions in numerous types of tissues including breast, prostate, liver, blood vessels, thyroid, musculoskeletal structures, and salivary glands. Purpose To evaluate the efficacy and application of real-time qualitative sonoelastography in the differentiation of benign and malignant focal parotid gland lesions. Material and Methods A total of 75 patients (36 boys/men, 39 girls/women; age range, 10–83 years) with 81 lesions were evaluated prospectively by sonoelastography performed and interpreted by two expert radiologists. The results of these experts classification and scoring of lesions according to relative stiffness of the mass were compared with each other and with histopathological findings. The interpretation of sonoelastography scores of 1–4 were as follows: 1, soft; 2, mostly soft; 3, mostly stiff; and 4, stiff. Results The kappa statistic of 0.508 (P <, 0.001) indicated moderate agreement between the two radiologists. The sonoelastography scores correctly diagnosed 30 of 49 benign tumors (sensitivity, 61.2%) and 19 of 32 malignant tumors (specificity, 59.4%). The area under the receiver-operating characteristic curve was 0.603. The diagnostic value of sonoelastography for evaluating pleomorphic adenomas, Warthin tumors, adenoid cystic carcinoma, and high-grade tumors was low, whereas the diagnostic rates for low-grade tumors such as mucoepidermoid carcinoma, acinic cell carcinoma, and metastases of basal cell carcinoma were better with sonoelastography. Conclusion Although sonoelastography seems to be promising in the differentiating of low-grade malignancies, the primary role of radiology is currently limited to determination of localization, size, and morphology of parotid tumors.

Malignant Epithelial Tumors of the Parotid Gland

2021 ◽  
pp. 213-232
Keyword(s):  
Parotid Gland ◽  
Cell Carcinoma ◽  
De Novo ◽  
Malignant Tumors ◽  
Large Cell Carcinoma ◽  
Low Grade ◽  
Parotid Tumors ◽  
Characteristic Features ◽  
Epithelial Myoepithelial Carcinoma ◽  
The Individual

Cancer of the parotid gland represents about 20% of all parotid tumors. It either occurs “de-novo” or “on top of pleomorphic adenoma.” There is no sex predilection, and the age of developing this cancer is usually above 50 years. Malignant tumors are as varied as their benign counterparts. Certain tumors are “low-grade” (polymorphous low-grade adenocarcinoma, acinic cell carcinoma, epithelial-myoepithelial carcinoma), while others are “high-grade” (salivary duct carcinoma, large cell carcinoma, and small cell carcinoma). The first echelon lymph node (LN) of metastases is the intra- and peri-glandular nodes. The next echelon is level II LNs. Hematogenous spread occurs very late and is mainly to the lungs and bones. However, adenoid cystic carcinoma tends to grow through peri-neural lymphatics with increased risk of nerve involvement, intra-cranial extension, and increased rate of recurrence. In this chapter, characteristic features and management of the individual types of malignant parotid tumors will be discussed.

scholarly journals Dedifferentiated Acinic Cell Carcinoma of the Parotid Gland With Myoepithelial Features

2002 ◽  
Vol 126 (9) ◽  
pp. 1104-1105 ◽  
Author(s):  
Simonetta Piana ◽  
Alberto Cavazza ◽  
Corrado Pedroni ◽  
Rosa Scotti ◽  
Luigi Serra ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Clinical Course ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Epithelial Proliferation ◽  
Acinic Cell

Abstract Dedifferentiated acinic cell carcinoma of the salivary gland is an uncommon variant of acinic cell carcinoma, characterized by the coexistence of both an usual low-grade acinic cell carcinoma and a high-grade dedifferentiated component, as well as by an accelerated clinical course. We describe a case of acinic cell carcinoma of the parotid gland in a 67-year-old woman, which recurred 4 times after surgery and radiotherapy. The recurrences consisted of residual foci of acinic cell carcinoma intermingled with a high-grade epithelial proliferation; the latter was focally constituted by cells with morphologic and immunohistochemical features of myoepithelium.

Dendritic Interstitial and Myofibroblastic Cells at the Border of Salivary Gland Tumors

2001 ◽  
Vol 125 (2) ◽  
pp. 232-236
Author(s):  
Lori Soma ◽  
Virginia A. LiVolsi ◽  
Zubair W. Baloch
Keyword(s):  
Smooth Muscle ◽  
Salivary Gland ◽  
Malignant Tumors ◽  
Smooth Muscle Actin ◽  
Staining Intensity ◽  
Interstitial Cells ◽  
Salivary Gland Tumors ◽  
Benign Tumors ◽  
Low Grade ◽  
Muscle Actin

Abstract Objective.—CD34-positive dendritic interstitial cells may be associated with the regulation of tumor growth. This association has been studied in various human neoplasms, especially skin tumors. In this study, we evaluated the distribution of dendritic interstitial cells and myofibroblastic cells at the tumor periphery of various benign and malignant salivary gland neoplasms. Methods.—Forty-nine cases of salivary gland tumors were selected: 16 pleomorphic adenomas, 12 Warthin tumors, 8 polymorphous low-grade tumors, 5 adenoid cystic carcinomas, 6 acinic cell carcinomas, and 2 mucoepidermoid carcinomas. Immunohistochemical analysis was performed by using antibodies for CD34 (dendritic cells) and α-smooth muscle actin (myofibroblast) on formalin-fixed, paraffin-embedded archival tissue. Staining intensity was graded as marked (3+), moderate (2+), weak (1+), and absent (0). Results.—Staining intensity for CD34 was 3+ in 24 (86%) of 28 benign tumors (pleomorphic adenomas and Warthin tumors) and 6 (29%) of 21 malignant tumors (polymorphous low-grade tumors, acinic cell carcinomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas) and 2+ in 4 (19%) of 21 malignant tumors. None of the benign tumors displayed 2+ staining with CD34. Three (11%) of 28 benign and 11 (52%) of 21 of malignant tumors failed to stain with CD34. α-Smooth muscle actin staining was 3+ in 10 (36%) of 28 benign tumors and 6 (29%) of 21 malignant tumors, and 2+ in 11 (39%) of 28 benign and 2 (9%) of 21 malignant tumors. Five (18%) of 28 benign and 11 (52%) of 21 malignant tumors failed to stain with α-smooth muscle actin. Conclusion.—We conclude that the dendritic interstitial cells and myofibroblastic cells may be associated with the regulation of tumor growth in salivary gland tumors.

HISTOPATHOLOGICAL SPECTRUM OF SKIN LESIONS: A TWO YEAR RETROSPECTIVE STUDY.

2021 ◽  
pp. 26-29
Author(s):  
Shruti Shemawat ◽  
Sakshi Apurva ◽  
D.P Soni ◽  
Saurabh Soni
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Relative Frequency ◽  
Malignant Tumors ◽  
Skin Lesions ◽  
Benign Tumors ◽  
Histopathological Diagnosis ◽  
Neoplastic Lesions ◽  
Skin Biopsies ◽  
Age And Sex

INTRODUCTION: The skin being largest organ of the body has vast spectrum of disorders which can be difcult to diagnose correctly solely on the basis of clinical features. Hence histopathological examination is necessary to categorise skin lesions. The aim was to study relative frequency of various skin lesions and distribution of these lesions according to age and sex. METHODS: This is a retrospective descriptive hospital based study. The skin biopsies samples which came in the duration of two years from January 2019 to December 2020 at the Department of Pathology, Sardar Patel Medical college and associated group of hospitals, Bikaner, Rajasthan were taken in this study. All skin biopsies that showed denite histopathological diagnosis were included. After proper xing and staining procedures these lesions were examined under light microscopy and categorized as non-neoplastic and neoplastic. Relative frequency of various lesions, distribution of lesions according to age and sex was analyzed. The data collected was tabulated, interpreted and compared with other similar studies. RESULTS: Out of 346 patients, incidence of neoplastic lesions 259 (74.9%) were higher than non-neoplastic lesions 87(25.1%). Males were affected more compared to females with male to female ratio 1.45:1. Non-neoplastic lesions were mostly caused because of infectious etiologies among which leprosy was the most common infection. Keratinocytic tumors 99(52.2%) constituted most common type of neoplastic lesion. Benign tumors 191(73.7%) outnumbered malignant tumors 68(26.3%). The cases of benign tumors were seen more in younger population while that of malignant tumors were seen in older age groups. Among the keratinocytic type of malignant skin tumors squamous cell carcinoma (63.5%) was the most common variant which was followed by basal cell carcinoma 19(36.5%). Male predominance was observed in both squamous cell carcinoma and basal cell carcinoma. CONCLUSION: A wide heterogenesity of skin lesions was observed in the present study . These skin lesions were mostly affecting age group of 10-30 years. Inspite of extensive programmes and research, leprosy and tuberculosis remains a rampant cause of infectious non-neoplastic skin lesions. Sometimes ignorance by patient for a very small appearing skin lesions becomes life threatening. Hence early clinician consultation with proper examination and accurate histopathological diagnosis becomes the mainstay in early treatment and recovery.

Incidence of benign versus malignant renal tumors in selected studies.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 357-357 ◽  
Author(s):  
Paul Russo ◽  
Robert G. Uzzo ◽  
William Thomas Lowrance ◽  
Aviva Asnis-Alibozek ◽  
Norman David LaFrance ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Malignant Tumors ◽  
Early Stage ◽  
Renal Tumors ◽  
Benign Tumors ◽  
Stage Migration ◽  
Renal Masses ◽  
Definitive Method

357 Background: Use of cross-sectional imaging has increased the detection rate for small renal tumors; more patients now present with early-stage renal cell carcinoma (RCC) or benign or indolent renal masses. Histopathology after surgical resection is the definitive method for characterizing renal tumors. Stage migration of renal masses creates uncertainty about the percentage of resected masses that will be benign vs malignant. We sought to better define these proportions through a targeted review of the literature. Methods: PubMed/select congresses were searched to identify the histologic classification of renal masses in a representative sample from the contemporary literature: [search] incidence AND (renal cell carcinoma AND benign); incidence AND (renal tumor AND benign); percentage AND (renal cell carcinoma AND benign); limit: 2003–2011. Results: Most representative studies included procedures conducted in the mid-1990s to the mid-to-late 2000s. Studies origin was US (n=8), Korea (n=3), China, Japan, Germany, Austria, Australia, and multisite (Israel/France/US; all n=1). Only 8 studies had n≥500 (range, 70–10,404). The proportion of benign masses are shown (see Table); half of the studies reported values between 16% and 17%. The majority found that benign tumors were more likely to be smaller in size (<4 or <7 cm) than malignant tumors. 11 studies reported the RCC subtype (% clear cell range, 46%–83%). Conclusions: Benign renal tumors occur ~15% of the time and are more prevalent among small masses. Nearly 25% of resected lesions are benign or indolent and may not require surgery. Preoperative discrimination of more aggressive renal masses would be an important clinical advance that could improve clinicians’ diagnostic confidence and guide patient management. Funding: Wilex AG/IBA Molecular. [Table: see text]

scholarly journals HISTOPATHOLOGICAL SPECTRUM OF NEOPLASTIC LESIONS OF KIDNEY- A THREE YEARS STUDY

2021 ◽  
Vol 5 (6) ◽  
Author(s):  
Saket Sarswat ◽  
Vimlesh . ◽  
D.P. Soni
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Wilms Tumor ◽  
Malignant Tumors ◽  
Pathological Process ◽  
Benign Tumors ◽  
Older Individuals ◽  
Neoplastic Lesions ◽  
Paediatric Age

Background: Kidney can be involved in various pathological process. Both benign & malignant tumors can occur in the kidney. They arise from different components of renal parenchyma, notably tubular epithelium.1 99 percent of renal neoplasms are malignant, with renal cell carcinoma and wilm’s tumor being the most common2. Men have higher incidence than women (approximately 1.6:1) and vast majority are diagnosed after 65 years of age. Material and methods: Prospective and retrospective study from January 2017 to December 2019 in the Department of Pathology. Results: The study comprised of 67 cases of neoplastic conditions, out of which 63 cases are malignant and only 4 cases were recorded as benign. Conclusion: Malignant tumors far more common than benign lesions. In adults and older individuals, renal cell carcinoma was most common while among paediatric age group, wilms tumor was most common. Benign tumors were uncommon. Keywords: Kidney, renal cell carcinoma, wilms tumor

scholarly journals Spontaneous Rupture of Renal Cell Carcinoma: A Rare Case Report

2020 ◽  
pp. 1-3
Author(s):  
Richa Chauhan ◽  
Richa Chauhan ◽  
Gyanendra Singh ◽  
Upendra Prasad Singh
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Tumor ◽  
Renal Cell ◽  
Spontaneous Rupture ◽  
Renal Mass ◽  
Malignant Tumors ◽  
Imaging Modality ◽  
Benign Tumors ◽  
Contrast Enhanced Ct

Renal cell carcinoma (RCC) is an uncommon malignant tumor of the kidney, particularly in the Asian population. It is more commonly seen in an elderly male patient with typical complains of haematuria, flank pain and lump. Recently incidental diagnosis of small RCCs has been rising due to increased used of abdominal imaging for other reasons. Spontaneous rupture of a renal mass leading to large perinephric collection and presenting as an acute pain abdomen in an adult male is a rare finding but should be considered as a differential diagnosis. The most common cause of spontaneously ruptured renal mass includes benign tumor as angiomyolipoma followed by malignant tumor like RCC, vascular causes, coagulation defects and infection in other cases. Contrast enhanced CT scan is the most common imaging modality used for diagnosis. Initial resuscitation depending up on the patient’s general condition followed by nephrectomy for malignant tumors and embolization for benign tumors is the treatment of choice.

scholarly journals Radiomics Models for the Preoperative Prediction of Pelvic and Sacral Tumor Types: A Single-Center Retrospective Study of 795 Cases

2021 ◽  
Vol 11 ◽  
Author(s):  
Ping Yin ◽  
Xin Zhi ◽  
Chao Sun ◽  
Sicong Wang ◽  
Xia Liu ◽  
...  
Keyword(s):  
Clinical Decision Making ◽  
Malignant Tumors ◽  
Characteristic Curve ◽  
Benign Tumors ◽  
Giant Cell Tumors ◽  
Neurogenic Tumors ◽  
Sacral Tumor ◽  
Sacral Tumors ◽  
Tumor Types ◽  
Class Models

PurposeTo assess the performance of random forest (RF)-based radiomics approaches based on 3D computed tomography (CT) and clinical features to predict the types of pelvic and sacral tumors.Materials and MethodsA total of 795 patients with pathologically confirmed pelvic and sacral tumors were analyzed, including metastatic tumors (n = 181), chordomas (n = 85), giant cell tumors (n =120), chondrosarcoma (n = 127), osteosarcoma (n = 106), neurogenic tumors (n = 95), and Ewing’s sarcoma (n = 81). After semi-automatic segmentation, 1316 hand-crafted radiomics features of each patient were extracted. Four radiomics models (RMs) and four clinical-RMs were built to identify these seven types of tumors. The area under the receiver operating characteristic curve (AUC) and accuracy (ACC) were used to evaluate different models.ResultsIn total, 795 patients (432 males, 363 females; mean age of 42.1 ± 17.8 years) were consisted of 215 benign tumors and 580 malignant tumors. The sex, age, history of malignancy and tumor location had significant differences between benign and malignant tumors (P &lt; 0.05). For the two-class models, clinical-RM2 (AUC = 0.928, ACC = 0.877) performed better than clinical-RM1 (AUC = 0.899, ACC = 0.854). For the three-class models, the proposed clinical-RM3 achieved AUCs between 0.923 (for chordoma) and 0.964 (for sarcoma), while the AUCs of the clinical-RM4 ranged from 0.799 (for osteosarcoma) to 0.869 (for chondrosarcoma) in the validation set.ConclusionsThe RF-based clinical-radiomics models provided high discriminatory performance in predicting pelvic and sacral tumor types, which could be used for clinical decision-making.

scholarly journals Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland

2019 ◽  
Vol 8 (9) ◽  
pp. 1315 ◽  
Author(s):  
Stefan Grasl ◽  
Stefan Janik ◽  
Matthaeus C. Grasl ◽  
Johannes Pammer ◽  
Michael Formanek ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Cell Carcinoma ◽  
Disease Free Survival ◽  
Retrospective Chart Review ◽  
Acinic Cell Carcinoma ◽  
Elective Neck Dissection ◽  
Low Grade ◽  
Acinic Cell ◽  
Neck Metastases ◽  
High Grade Carcinoma

The objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland. Clinical parameters were retrieved and statistically analyzed regarding disease-free survival (DFS) and disease-specific survival (DSS). An END was done in 27 (40.9%) patients, and occult metastases were detected in 4 (14.8%) patients of whom three were low-grade carcinoma. Positive neck nodes were associated with significantly worse DSS (p = 0.05). Intermediate and high-grade carcinoma (HR 8.62; 95% confidence interval (CI): 1.69–44.01; p = 0.010), perineural invasion (HR 19.6; 95%CI: 0.01–0.37; p = 0.003) and lymphovascular invasion (HR 10.2; 95%CI: 0.02–0.59; p = 0.011) were worse prognostic factors for DFS. An END should be considered in patients with acinic cell carcinoma of the parotid gland due to (i) a notable rate of occult neck metastases in low-grade tumors and (ii) the worse DSS of patients with positive neck nodes.

scholarly journals Pattern of ocular tumors in the eastern region of Nepal

1970 ◽  
Vol 1 (1) ◽  
pp. 9-12 ◽  
Author(s):  
P Lavaju ◽  
SK Arya ◽  
A Sinha ◽  
S Pandey ◽  
S Adhikari ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Malignant Tumors ◽  
Benign Tumors ◽  
Eastern Region ◽  
Cystic Lesions ◽  
Age Group ◽  
Pediatric Age Group ◽  
Adults And Children

Background: Ocular tumors are commonly encountered in ophthalmic practice. Objective: To study the clinical pattern of ocular tumors in the eastern region of Nepal. Materials and methods: The hospital records of patients with ocular tumors treated at B P Koirala Institute of Health Sciences in the eastern region of Nepal over a period of 5 years (April 2003 - March 2008) were studied retrospectively. Results: Of 115 consecutive patients with ocular tumors, 40 (34.75%) were below the age of 21 years, 41 (35.65%) were in the age group of 21-50 years and 34 (29.56%) of age above 50 years. There were 48 (41.73%) and 67 (58.26%) patients with benign and malignant tumors respectively. The common benign tumors were conjunctival papilloma, dermoid cysts, nevus, cystic lesions and hemangioma. Among the malignant tumors, basal cell carcinoma was the commonest (22.38%). Retinoblastoma was the most common ocular malignant tumor in the pediatric age group (88.8%). Basal cell carcinoma was the commonest eyelid malignancy 53.57%. Conclusion: Conjunctival papilloma, dermoid cysts, nevus, cystic lesions and hemangioma are common benign ocular tumors, whereas basal cell carcinoma and retinoblastoma are the commonest ocular malignancies in adults and children respectively. Key words: ocular malignancy; retinoblastoma; basal cell carcinoma DOI: 10.3126/nepjoph.v1i1.3667 Nep J Oph 2009;1(1):9-12

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