A young patient of hereditary renal hypouricaemia presenting with exercise-induced rhabdomyolysis and acute kidney injury

2013 ◽  
Vol 50 (3) ◽  
pp. 271-273 ◽  
Author(s):  
Sutirtha Chakraborty ◽  
Saubhik Sural
Keyword(s):  
Acute Kidney Injury ◽  
Young Patient ◽  
Kidney Injury ◽  
Renal Hypouricaemia ◽  
Exercise Induced

Acute kidney injury in two children caused by renal hypouricaemia type 2

2012 ◽  
Vol 27 (8) ◽  
pp. 1411-1415 ◽  
Author(s):  
Blanka Stiburkova ◽  
Judy Taylor ◽  
Anthony M. Marinaki ◽  
Ivan Sebesta
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Renal Hypouricaemia

scholarly journals Renal hypouricemia with exercise induced acute kidney injury-A case report

2020 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Srikanth Gundlapalli ◽  
Yogesh Gaur ◽  
MVenkateswar Rao ◽  
SujeethReddy Bande ◽  
P Sandhya
Keyword(s):  
Acute Kidney Injury ◽  
Case Report ◽  
Kidney Injury ◽  
Renal Hypouricemia ◽  
Exercise Induced

scholarly journals A Case of Acute Kidney Injury in a Patient with Renal Hypouricemia without Intense Exercise

2020 ◽  
Vol 10 (1) ◽  
pp. 26-34
Author(s):  
Daiki Aomura ◽  
Kosuke Sonoda ◽  
Makoto Harada ◽  
Koji Hashimoto ◽  
Yuji Kamijo
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Risk Factor ◽  
Conservative Treatment ◽  
Kidney Injury ◽  
Intense Exercise ◽  
Kidney Dysfunction ◽  
Renal Hypouricemia ◽  
Orthostatic Dysregulation ◽  
Exercise Induced

Exercise-induced acute kidney injury (EIAKI) frequently develops in patients with renal hypouricemia (RHUC). However, several cases of RHUC with acute kidney injury (AKI) but without intense exercise have been reported. We encountered a 15-year-old male with RHUC who experienced AKI. He reported no episodes of intense exercise and displayed no other representative risk factors of EIAKI, although a vasopressor had been administered for orthostatic dysregulation before AKI onset. His kidney dysfunction improved with discontinuation of the vasopressor and conservative treatment. Thus, AKI can develop in patients with RHUC in the absence of intense exercise, for which vasopressors may be a risk factor.

Exercise-Induced Acute Kidney Injury: A Case of Renal Hypouricemia

2015 ◽  
Vol 24 (2) ◽  
pp. 217-219
Author(s):  
Simge Bardak ◽  
Kenan Turgutalp ◽  
Ahmet Kiykim
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Renal Hypouricemia ◽  
Exercise Induced

scholarly journals Exercising in a hot environment with muscle damage: effects on acute kidney injury biomarkers and kidney function

2013 ◽  
Vol 305 (6) ◽  
pp. F813-F820 ◽  
Author(s):  
Naushad A. Junglee ◽  
Umberto Di Felice ◽  
Alberto Dolci ◽  
Matthew B. Fortes ◽  
Mahdi M. Jibani ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Muscle Damage ◽  
Kidney Function ◽  
Interleukin 6 ◽  
Heat Stroke ◽  
Kidney Injury ◽  
Random Order ◽  
Mean Difference ◽  
Exercise Induced ◽  
Hot Environments

Unaccustomed strenuous physical exertion in hot environments can result in heat stroke and acute kidney injury (AKI). Both exercise-induced muscle damage and AKI are associated with the release of interleukin-6, but whether muscle damage causes AKI in the heat is unknown. We hypothesized that muscle-damaging exercise, before exercise in the heat, would increase kidney stress. Ten healthy euhydrated men underwent a randomized, crossover trial involving both a 60-min downhill muscle-damaging run (exercise-induced muscle damage; EIMD), and an exercise intensity-matched non-muscle-damaging flat run (CON), in random order separated by 2 wk. Both treatments were followed by heat stress elicited by a 40-min run at 33°C. Urine and blood were sampled at baseline, after treatment, and after subjects ran in the heat. By design, EIMD induced higher plasma creatine kinase and interleukin-6 than CON. EIMD elevated kidney injury biomarkers (e.g., urinary neutrophil gelatinase-associated lipocalin (NGAL) after a run in the heat: EIMD-CON, mean difference [95% CI]: 12 [5, 19] ng/ml) and reduced kidney function (e.g., plasma creatinine after a run in the heat: EIMD-CON, mean difference [95% CI]: 0.2 [0.1, 0.3] mg/dl), where CI is the confidence interval. Plasma interleukin-6 was positively correlated with plasma NGAL ( r = 0.9, P = 0.001). Moreover, following EIMD, 5 of 10 participants met AKIN criteria for AKI. Thus for the first time we demonstrate that muscle-damaging exercise before running in the heat results in a greater inflammatory state and kidney stress compared with non-muscle-damaging exercise. Muscle damage should therefore be considered a risk factor for AKI when performing exercise in hot environments.

scholarly journals Mutation in the SLC2A9 Gene: A New Family with Familial Renal Hypouricemia Type 2

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Christian Maalouli ◽  
Karin Dahan ◽  
Arnaud Devresse ◽  
Valentine Gillion
Keyword(s):  
Acute Kidney Injury ◽  
Genetic Disorder ◽  
Kidney Injury ◽  
Type Ii ◽  
Renal Hypouricemia ◽  
New Family ◽  
Exercise Induced ◽  
Renal Tubular ◽  
Work Up

Familial renal hypouricemia is a rare genetic disorder characterized by a defect in renal tubular urate reabsorption. Some patients present with exercise-induced acute kidney injury and nephrolithiasis. Type II is caused by mutations in the SLC2A9 gene. Here, we report the case of a young patient who developed acute kidney injury after exercise secondary to familial renal hypouricemia type II. The same mutation was found in other asymptomatic members of his family. We review the medical literature on this condition. This case highlights the importance of considering uric acid disorders in the work-up of acute kidney injury after exercise.

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