Effects of aromatase inhibition on bone mineral density and bone turnover in older men with low testosterone levels

2010 ◽  
Vol 47 (3) ◽  
pp. 284-284
Author(s):  
Wycliffe Mbagaya
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Older Men ◽  
Mineral Density ◽  
Aromatase Inhibition ◽  
Testosterone Levels ◽  
Low Testosterone

scholarly journals Effects of Aromatase Inhibition on Bone Mineral Density and Bone Turnover in Older Men with Low Testosterone Levels

2009 ◽  
Vol 94 (12) ◽  
pp. 4785-4792 ◽  
Author(s):  
Sherri-Ann M. Burnett-Bowie ◽  
Elizabeth A. McKay ◽  
Hang Lee ◽  
Benjamin Z. Leder
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Older Men ◽  
Gonadal Steroid ◽  
Mineral Density ◽  
Aromatase Inhibition ◽  
Testosterone Levels ◽  
Low Testosterone ◽  
Turnover Markers ◽  
Estradiol Levels

Context: Aging is associated with declining gonadal steroid production, low bone mineral density (BMD), and fragility fractures. The efficacy and safety of testosterone replacement in older men remains uncertain. Objective: The objective of the study was to assess the effects of aromatase inhibition on BMD in older men with low testosterone levels. Design and Setting: This was a 1-yr, double-blind, randomized, placebo-controlled trial that was conducted at a tertiary care academic center in Boston, MA. Participants: Participants included 69 men aged 60+ yr with borderline or low testosterone levels and hypogonadal symptoms. Intervention: Intervention included 1 mg anastrozole daily or placebo. Main Outcome Measures: Changes in gonadal steroid hormone levels, BMD, and bone turnover markers were measured. Results: Mean serum testosterone increased from 319 ± 93 ng/dl at baseline to 524±139 ng/dl at month 3 (P < 0.0001) and declined slightly to 474 ± 145 ng/dl by 1 yr. Estradiol levels decreased from 15 ± 4 pg/ml at baseline to 12 ± 4 pg/ml at month 3 and then remained stable (P < 0.0001). Posterior-anterior (PA) spine BMD decreased in the anastrozole group as compared with placebo (P = 0.0014). In the anastrozole group, PA spine BMD decreased from 1.121 ± 0.141 g/cm2 to 1.102 ± 0.138 g/cm2, whereas in the placebo group, PA spine BMD increased from 1.180 ± 0.145 g/cm2 to 1.189 ± 0.146 g/cm2. Qualitatively similar, but not statistically significant, changes occurred at the other sites. Bone turnover markers were not affected by anastrozole therapy. Conclusions: In older men, aromatase inhibition increases testosterone levels, decreases estradiol levels, and appears to decrease BMD. Aromatase inhibition does not improve skeletal health in aging men with low or low normal testosterone levels.

scholarly journals Complex interplay among fat, lean tissue, bone mineral density and bone turnover markers in older men

Aging ◽  
2020 ◽  
Vol 12 (19) ◽  
pp. 19539-19545
Author(s):  
Aleksandra Rył ◽  
Iwona Rotter ◽  
Aleksandra Szylińska ◽  
Alina Jurewicz ◽  
Andrzej Bohatyrewicz ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Older Men ◽  
Mineral Density ◽  
Complex Interplay ◽  
Lean Tissue ◽  
Turnover Markers
Sign in / Sign up

Export Citation Format

Share Document