scholarly journals C-reactive protein and procalcitonin concentrations in bronchoalveolar lavage fluid as a predictor of ventilator-associated pneumonia

2008 ◽  
Vol 45 (3) ◽  
pp. 293-298 ◽  
Author(s):  
C. F M Linssen ◽  
O. Bekers ◽  
M. Drent ◽  
J. A Jacobs
Keyword(s):  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Ventilator Associated Pneumonia ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Biochemistry in Assessing the Inflammatory Response of the Respiratory System Due to Experimental Exposure to Glass Fibres

2019 ◽  
Vol 56 (1) ◽  
pp. 285-290
Author(s):  
Bianca Domokos-Hancu ◽  
Milena Adina Man ◽  
Antigona Carmen Trofor ◽  
Carmen Monica Pop ◽  
Cristina Maria Gavrilescu ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Bronchoalveolar Lavage ◽  
Glass Fiber ◽  
Respiratory System ◽  
Bronchoalveolar Lavage Fluid ◽  
Glass Fibers ◽  
Lavage Fluid ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Weight Variation

Given the structural resemblances between glass fiber and asbestos, it is important to understand the mechanisms through which exposure to glass fibers may affect the respiratory system. To study the effect of glass fiber on rat lung through intratracheal exposure, considering the subject�s weight variation, together with haematological parameters, C-reactive protein (CRP), total number of lymphocytes, and IL8 concentration in bronchoalveolar lavage. We performed an intratracheal instillation study on four groups of 8 randomly selected Wistar rats, by administering 3 different doses of glass fiber. The hematocrit value was an indirect indicator of chronic hypoxemia; leukocytes and the C-reactive protein assessed systemic inflammation, and total number of lymphocytes and IL8 concentration in bronchoalveolar lavage fluid determined the lung�s inflammatory response. Weight variation evaluated in all 8 measurements revealed no statistically significant changes (p=0.768). The decrease in mean blood leukocytes was interpreted in relation with the glass fiber dose, with a statistically significant difference between the study groups (p=0.003). Statistically significant differences were found in the CRP values, with dose correlations (p[0.001). The bronchoalveolar lavage fluid showed increased levels of IL-8 (p[0.05), and decrease of lymphocytes (p[0.001) in correlation with the administered glass fiber dose. The inflammatory response following exposure to glass fibers in rats is correlated with administrated glass fiber dose. The alterations described as a result of intratracheal glass fiber instillation could predict the effects which occupational exposure to glass fiber may produce in humans.

C-Reactive Protein in Bronchoalveolar Lavage Fluid is Associated With Markers of Airway Inflammation After Lung Transplantation

2009 ◽  
Vol 41 (8) ◽  
pp. 3409-3413 ◽  
Author(s):  
R. Vos ◽  
B.M. Vanaudenaerde ◽  
S.I. De Vleeschauwer ◽  
A. Willems-Widyastuti ◽  
L.J. Dupont ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Lung Transplantation ◽  
Airway Inflammation ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Azithromycin Attenuates Lung Inflammation in a Mouse Model of Ventilator-Associated Pneumonia by Multidrug-Resistant Acinetobacter baumannii

2013 ◽  
Vol 57 (8) ◽  
pp. 3883-3888 ◽  
Author(s):  
Koichi Yamada ◽  
Katsunori Yanagihara ◽  
Norihito Kaku ◽  
Yosuke Harada ◽  
Yohei Migiyama ◽  
...  
Keyword(s):  
Mouse Model ◽  
Bronchoalveolar Lavage ◽  
Acinetobacter Baumannii ◽  
Lung Inflammation ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Multidrug Resistant ◽  
Control Group ◽  
Ventilator Associated Pneumonia ◽  
Content Type

ABSTRACTAcinetobacter baumanniiis one of the main pathogens that cause ventilator-associated pneumonia (VAP) and is associated with a high rate of mortality. Little is known about the efficacy of macrolides againstA. baumannii. In order to confirm the efficacy of azithromycin (AZM) against VAP caused by multidrug-resistantA. baumannii(MDRAB), we used a mouse model that mimics VAP by placement of a plastic tube in the bronchus. AZM (10 and 100 mg/kg of body weight) was administered subcutaneously every 24 h beginning at 3 h after inoculation. Phosphate-buffered saline was administered as the control. Survival was evaluated over 7 days. At 48 h postinfection, mice were sacrificed and the numbers of viable bacteria in lungs and bronchoalveolar lavage fluid were compared. Histopathological analysis of lung specimens was also performed. The treatment groups displayed significantly longer survival than the control group (P< 0.05). AZM did not have an antimicrobial effect. Histopathological examination of lung specimens indicated that the progression of lung inflammation was prevented in the AZM-treated groups. Furthermore, total cell and neutrophil counts, as well as cytokine levels, in bronchoalveolar lavage fluid were significantly decreased (P< 0.05) in the AZM-treated groups. AZM may have a role for the treatment of VAP with MDRAB because of its anti-inflammatory effects.

scholarly journals C-Reactive Protein Kinetics in Prognosis of Ventilator Associated Pneumonia

2020 ◽  
Author(s):  
Chandan Kumar Shit ◽  
Sudarsan Pothal ◽  
Aurobindo Behera ◽  
Rekha Manjhi ◽  
Pravati Dutta ◽  
...  
Keyword(s):  
Low Cost ◽  
Tracheal Aspirate ◽  
Lavage Fluid ◽  
Ventilator Associated Pneumonia ◽  
C Reactive Protein ◽  
Site Assessment ◽  
Reactive Protein ◽  
Observational Cohort ◽  
Chest X Ray ◽  
The Mean

Introduction: Prognosis of Ventilator Associated Pneumonia (VAP) is commonly predicted by on-site assessment of clinical, haematological and biochemical parameters. Sequential measurement of C-Reactive Protein (CRP) which is one of the low-cost biomarkers could be useful in the early identification of poor outcome of VAP. Aim: To assess the prognostic value of progressive CRP levels in patients with VAP and compare with non-VAP group of ventilated patients. Materials and Methods: This was a prospective observational cohort study at medico-surgical ICU between November 2017 and October 2018. The patients on mechanical ventilator for more than 48 hours were divided into VAP (n=27) and non-VAP group (n=38). VAP was considered based on modified Clinical Pulmonary Infection Score (CPIS) more than 6 along with microbiological evidence from Tracheal aspirate or Bronchoalveolar lavage fluid with consolidation in Chest X-ray. Study subjects were monitored for the development of VAP. CRP measurements were done daily for the first 7 days then on 14th day. The evolution of mean CRP concentration throughout the course of VAP and non-VAP were analysed and compared between survivors and non-survivors. Results: Mean CRP level of VAP patients on the day of diagnosis was almost similar to non-VAP cohort. The mean CRP of non-survivor groups of both VAP and non-VAP patients had shown a gradual increase after day 4. However, the mean CRP after day 4, in the survivor group of both VAP and non-VAP showed either decreasing or unchanged trends. Conclusion: It was evident that the dynamics of the CRP levels in patients with VAP can be used to assess the effects of the therapy for a better outcome.

Utility of procalcitonin for differentiating cryptogenic organising pneumonia from community-acquired pneumonia

2019 ◽  
Vol 57 (10) ◽  
pp. 1632-1637 ◽  
Author(s):  
Akihiro Ito ◽  
Tadashi Ishida ◽  
Hiromasa Tachibana ◽  
Machiko Arita ◽  
Akio Yamazaki ◽  
...  
Keyword(s):  
Operating Characteristic ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Community Acquired Pneumonia ◽  
C Reactive Protein ◽  
Roc Curve Analysis ◽  
Histopathological Findings ◽  
Reactive Protein ◽  
Auc Value ◽  
Wbc Count

Abstract Background This study aimed to investigate the usefulness of inflammatory biomarkers such as white blood cell (WBC) count, C-reactive protein (CRP) and procalcitonin (PCT) for differentiating cryptogenic organising pneumonia (COP) from community-acquired pneumonia (CAP). Methods COP patients hospitalised in Kurashiki Central Hospital between January 2010 and December 2017 whose WBC counts and CRP and PCT levels were measured were investigated retrospectively, and their results were compared with those of hospitalised CAP patients who were prospectively enrolled between October 2010 and November 2017. Definite COP was defined by specific histopathological findings, and possible COP was defined as a consolidation shadow on chest computed tomography and lymphocyte dominance in bronchoalveolar lavage fluid in the absence of specific histopathological findings or lung specimens. The discriminatory abilities of WBC counts, CRP and PCT were evaluated by receiver operating characteristic (ROC) curve analysis. Results There were 56 patients in the entire COP group, 35 (61.4%) with definite COP, and 914 CAP patients. All three biomarkers were significantly lower in COP than in CAP. The AUC value of PCT in all COP patients was 0.79, significantly higher than of both CRP (AUC 0.59, p < 0.001) and WBC (AUC 0.69, p = 0.048). In definite COP patients, the AUC value of PCT was 0.79, which was also significantly higher than of both WBC (AUC 0.64, p = 0.006) and CRP (AUC 0.64, p = 0.001). Conclusions PCT is a more useful biomarker for differentiating COP from CAP than WBC count or CRP. However, PCT should be used as an adjunct to clinical presentation and radiological findings.

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