Spleen and liver weight changes in NZB mice with haemolytic anaemia

1975 ◽  
Vol 9 (4) ◽  
pp. 261-273 ◽  
Author(s):  
L. O. Simpson
Keyword(s):  
Multivariate Analysis ◽  
Liver Weight ◽  
Spleen Weight ◽  
Red Cell ◽  
Weight Changes ◽  
Haemolytic Disease ◽  
3 Dimensional ◽  
Dominant Feature ◽  
Relationship Of ◽  
The Relationship

Spleen and liver weights from 998 NZB mice were subjected to computerised multivariate analysis. 3-dimensional graphs relating predicted spleen and liver weights to age and body weight were prepared and the relationship of the fitted surface to the histology and pathological autoantibody is discussed. On the basis of spleen weight increase, red-cell destruction throughout the greater part of life seems to be mainly intrasplenic, while intrahepatic destruction does not become important until later, when it is probably a dominant feature in the terminal period of the disease. Only limited organ weight increases occur in breeding females, and it is suggested that pregnancy lessens the effect of the haemolytic disease, the 'protective' effect extending long after the cessation of breeding.

scholarly journals Plasma and Red Cell Reference Intervals of 5-Methyltetrahydrofolate of Healthy Adults in Whom Biochemical Functional Deficiencies of Folate and Vitamin B12Had Been Excluded

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Agata Sobczyńska-Malefora ◽  
Dominic J. Harrington ◽  
Kieran Voong ◽  
Martin J. Shearer
Keyword(s):  
Methylmalonic Acid ◽  
Reference Intervals ◽  
Healthy Adults ◽  
Molecular Forms ◽  
Vitamin B ◽  
Red Cell ◽  
Relationship Of ◽  
The Relationship ◽  
Plasma Measurements ◽  
Functional Deficiency

5-Methyltetrahydrofolate (5-MTHF) is the predominant form of folate and a strong determinant of homocysteine concentrations. There is evidence that suboptimal 5-MTHF availability is a risk factor for cardiovascular disease independent of homocysteine. The analysis of folates remains challenging and is almost exclusively limited to the reporting of “total” folate rather than individual molecular forms. The purpose of this study was to establish the reference intervals of 5-MTHF in plasma and red cells of healthy adults who had been prescreened to exclude biochemical evidence of functional deficiency of folate and/or vitamin B12. Functional folate and vitamin B12status was assessed by respective plasma measurements of homocysteine and methylmalonic acid in 144 healthy volunteers, aged 19–64 years. After the exclusion of 10 individuals, values for 134 subjects were used to establish the upper reference limits for homocysteine (13 μmol/L females and 15 μmol/L males) and methylmalonic acid (430 nmol/L). Subjects with values below these cutoffs were designated as folate and vitamin B12replete and their plasma and red cell 5-MTHF reference intervals determined,N=126: 6.6–39.9 nmol/L and 223–1041 nmol/L, respectively. The application of these intervals will assist in the evaluation of folate status and facilitate studies to evaluate the relationship of 5-MTHF to disease.

scholarly journals Pola Asuh Orang Tua Terhadap Anak Berdasarkan Golongan Darah

2019 ◽  
Vol 4 (2) ◽  
pp. 114-129
Author(s):  
Hamam Burhanuddin
Keyword(s):  
Social Interaction ◽  
The Body ◽  
Blood Type ◽  
Relationship With God ◽  
3 Dimensional ◽  
Islamic Studies ◽  
Stage Of Development ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain

The study in this paper are explain about the studies of medical (medicine) blood type have the same relationship to human character because the blood producing antibodies and antigens. It could determine a person helpless hold strong or weak body, has an allergy to something or not, in the blood also contains various nutrients (like protein) and also the oxygen being supplied to the brain and nerves and body affect performance someone will then be emanated from the attitude of the person and social interaction. As has been explained, but keep in mind, there is blood in the genes, the nature of which is carried in the body/genotif rightly so it is, but we can not ignore the fenotif/nature arising or visible, this trait appear due to interaction between genes and the environment, so even if the person is smart in the intelligentsia and emotional, but grew up in a bad environment is going to be a bad trait. The theory of personality based on blood type can be used as a reference in parenting children through an understanding of the fundamental principles of the application of personality accompanied by parenting. Furthermore, the taking of steps in the care tailored to the stage of development of the child, in the Qur'an explicitly did not mentioned paragraph that discusses about blood type, but in the Qur'an there are blood (ad-Dam), Islamic studies in the study of Children is seen as a mandate from God, forming 3-dimensional relationships, with parents as the central figure. First, her parents relationship with God that is backed by the presence of children. Second, the relationship of the child (which still need a lot of guidance) with God through his parents. Third, the relationship of the child with both parents under the tutelage and guidance of God.

PSI-B-26 Association of leptin gene polymorphisms (C73T and C528T) on the development of internal organs in Aberdeen-angus cattle

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 224-225
Author(s):  
Alexandra Lapshina ◽  
Nikolay Gerasimov ◽  
Kinispay Dzhulamanov ◽  
Vladimir Kolpakov ◽  
Erzhan Dzhulamanov
Keyword(s):  
Financial Support ◽  
Gene Polymorphisms ◽  
Energy Exchange ◽  
Spleen Weight ◽  
Metabolic Processes ◽  
Internal Organs ◽  
Plant Foods ◽  
Angus Cattle ◽  
Relationship Of ◽  
The Relationship

Abstract Numerous studies have established the relationship of SNPs in the leptin gene with fat and energy exchange, nutritional behavior in cattle. In turn, the intensity of metabolic processes in body is determined by the development of internal organs. The purpose of research was to study the relationship between the complex of polymorphisms C73T and C528T in leptin gene for the formation of internal organs in Aberdeen-Angus cows and heifers. Cows (n = 30) and heifers (n = 49) were genotyped and identified respectively 7 and 8 various combinations of genotypes of C73T (GenBank AF120500) and C528T (GenBank AB070368). There were no homozygous CC/CC and TT/TT combinations in cows, and no TT/TT combination in heifers. Cows were slaughtered at the age of 3 years, and heifers - at 20 months. Cows with haplotype CT/CC had the highest liver, heart, lung, kidney and spleen weight with superiority relative to peers of 6.5–16.0% (P > 0.05). The minimum development of stomachs was established at cows with a combination of genotypes of CC/TT which conceded to analogs for 7.6–13.8% (P > 0.05). Haplotypes CT/CT and TT/CT in heifers were associated with greater internal organ massiveness. Carriers of complex CT/CT genotype outperformed peers in terms of liver, heart, lung, kidney and spleen weight by 1.75–6.59% (P < 0.05, P > 0.05), and individuals with a combination of TT/CT by 3.50–8.84% (P < 0.05, P > 0.05). Less developed stomachs were established in bodies with haplotype TT/CC, which were inferior to other genotypes by 1.20–7.49% (P < 0.05, P > 0.05). This indirectly indicates a relatively weak ability to use coarse plant foods. Thus, the complex genotype inleptin gene is associated with the variability in the development of internal organs, which determines the intensity of metabolic processes. This research was performed with financial support from the project of RAS0526-2021-0001.

scholarly journals Hemoglobin L Ferrara in a Jewish Family Associated with a Hemolytic State in the Propositus

Blood ◽  
1969 ◽  
Vol 34 (2) ◽  
pp. 157-165 ◽  
Author(s):  
RONALD L. NAGEL ◽  
HELEN M. RANNEY ◽  
THOMAS B. BRADLEY ◽  
ALAN JACOBS ◽  
LINDA UDEM
Keyword(s):  
Family Study ◽  
Simultaneous Occurrence ◽  
Red Cell ◽  
Jewish Family ◽  
Sh Groups ◽  
Red Cell Enzymes ◽  
Abnormal Hemoglobin ◽  
Relationship Of ◽  
The Relationship ◽  
Cell Defect

Abstract A Jewish family in which Hb L Ferrara (α247 Asp → Gly β2) occurred is reported. Studies of some of the properties of this hemoglobin demonstrated that its oxygen equilibria, number of readily reactive-SH groups, and spectro-photometric tyrosine titration were indistinguishable from Hb A. Nevertheless, Hb LF was more unstable than Hb A at 55 C. The propositus had accelerated blood destruction although six other heterozygotes for Hb LF did not. A second defect in red cell enzymes or red cell lipids of the propositus was not demonstrable with the technics used but the possibility that the simultaneous occurrence of Hb LF and an otherwise "silent" red cell defect may lead to a hemolytic state remains an attractive explanation. The data provided by this family study did not permit a definite conclusion about the relationship of clinically evident hemolysis in the propositus to the presence of the abnormal hemoglobin.

scholarly journals The Relationship of Bartonella Bacilliformis to the Red Blood Cell as Revealed by Electron Microscopy

Blood ◽  
1969 ◽  
Vol 33 (5) ◽  
pp. 708-716 ◽  
Author(s):  
MANUEL CUADRA ◽  
JUAN TAKANO
Keyword(s):  
Electron Microscopy ◽  
Blood Cell ◽  
Red Cells ◽  
Red Cell ◽  
Bartonella Bacilliformis ◽  
Coccoid Form ◽  
Blood Smears ◽  
Ultrathin Sections ◽  
Relationship Of ◽  
The Relationship

Abstract Ultrathin sections of erythrocytosis parasitized by B. bacilliformis have been examined by electron microscopy. The study concerns three Oroya Fever patients whose blood smears showed B. bacilliformis predominantly in its coccoid form as parastizing over 70 per cent of the red cells. B. bacilliformis is termed as a bacterium in its structure and appears to lie not only on the host red cells but predominantly within them. Therefore, this organism might have the capacity to penetrate into the red cell. This finding does not change the basic concept regarding the mechanism of the anemia of Oroya Fever.

scholarly journals 2315. The Relationship of Pre-Hospital Functional Status and Clinical Outcomes in Patients with Laboratory-Confirmed RSV Infection: Active Population-Based Surveillance, 2017–2019

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S794-S794
Author(s):  
Angela Branche ◽  
Lisa Saiman ◽  
Edward E Walsh ◽  
Ann R Falsey ◽  
William Sieling ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Functional Status ◽  
Clinical Outcomes ◽  
Demographic Data ◽  
Patient Characteristics ◽  
Population Based ◽  
Active Population ◽  
Rsv Infection ◽  
Relationship Of ◽  
The Relationship

Abstract Background Respiratory syncytial virus (RSV) infection is a common cause of acute respiratory infection (ARI) in adults. Prospective surveillance enables collection of representative data on demographic and clinical characteristics. Few data of this kind are available for adults hospitalized with RSV infection. We used active population-based surveillance to identify patients with laboratory-confirmed RSV infection and evaluated demographic characteristics and clinical outcomes. Methods Hospitalized adults ≥ 18 years old residing in a predefined catchment area with ≥ 2 ARI symptoms or exacerbation of underlying cardiopulmonary disease were screened for eligibility during October 2017–April 2018 and October 2018–April 2019 in 3 hospitals in Rochester, NY and New York City. Respiratory specimens were tested for RSV using PCR assays. Clinical and demographic data were abstracted from the medical record. Multivariate analysis was used to evaluate the relationship of patient characteristics with clinical outcomes. Results 8,217 hospitalized adults were screened and 9.4% positive for RSV infection. Preliminary clinical and demographic data were available for 348 patients including 14% 18–49 years, 28% 50–64 years and 58% > 65 years. Mean age was 68 years and 60% were female (Figure 1). Patients had a mean of 3 co-morbidities, with diabetes (40%), chronic obstructive pulmonary disease (30%), chronic kidney disease (28%), congestive heart failure (28%), coronary artery disease (25%) and asthma (24%) the most common co-morbidities (Figure 2). Median hospital length of stay was 6 days (IQR 4–10), 13% of patients were admitted to the ICU, 5% were mechanically ventilated and 5% died during admission and 12% within 6 months. In multivariate analysis having > 3 comorbidities, cardiac disease or a lower baseline functional status measured by activities of daily living scores was significantly associated with 6-month mortality. Conclusion The majority of hospitalized patients with RSV infection were older adults with ≥ 3 chronic comorbid conditions. Baseline functional status may be predictive of worse clinical outcomes in patients with RSV infection. These insights into patient characteristics and clinical outcomes will provide information for prevention programs. Disclosures All authors: No reported disclosures.

A Multivariate Analysis of Personality and Product Use

1971 ◽  
Vol 8 (1) ◽  
pp. 67-70 ◽  
Author(s):  
David L. Sparks ◽  
W. T. Tucker
Keyword(s):  
Multivariate Analysis ◽  
Personality Traits ◽  
Canonical Analysis ◽  
Use Patterns ◽  
Product Use ◽  
Relationship Of ◽  
The Relationship

A canonical analysis of the relationship of personality traits to product use patterns suggests that the association is significant and complex, involving probable interactions among traits.

The relationship of ornithine decarboxylase and thymidine kinase to mirex-induced liver growth

1986 ◽  
Vol 251 (6) ◽  
pp. G859-G865
Author(s):  
J. D. Yarbrough ◽  
J. M. Grimley ◽  
P. I. Karl
Keyword(s):  
Thymidine Kinase ◽  
Ornithine Decarboxylase ◽  
Thymidine Incorporation ◽  
Liver Weight ◽  
Biphasic Response ◽  
Liver Growth ◽  
Sequence Of Events ◽  
Relationship Of ◽  
The Relationship ◽  
Intact Rats

To investigate the sequence of events that occur in the liver during mirex-induced adaptive liver growth, [3H]thymidine incorporation into DNA, thymidine kinase (TK), and ornithine decarboxylase (ODC) were studied in intact and adrenalectomized (ADX) mirex-dosed rats, and the responses were compared with experimental groups receiving corticosterone. In intact mirex-dosed rats (a response that is both hyperplastic and hypertrophic) there was a 36-h peak in ODC activity, and a 48-h peak in both [3H]thymidine incorporation into DNA and TK activity. This was accompanied by a 72% increase in relative liver weight (RLW). In contrast, in ADX mirex-dosed rats (a predominately hyperplastic response), there was a biphasic ODC response (18- and 36-h peaks), a 36-h TK peak, and a 48-h peak in [3H]thymidine incorporation into DNA. Both TK activity and [3H]thymidine incorporation into DNA were significantly elevated for the remainder of the 96-h study period. There was a 38% increase in RLW. Corticosterone supplements to mirex-dosed intact rats resulted in a biphasic peak of TK activity (30- and 48-h peaks), a reduced ODC peak at 36 h, and a 48-h peak in [3H]thymidine incorporation into DNA. RLW response was similar to the response in intact mirex-dosed rats. Corticosterone supplements to mirex-dosed ADX rats eliminated the 48-h peak of [3H]thymidine incorporation into DNA, reduced TK activity and shifted the peak to 30 h, and eliminated the ODC biphasic response. The RLW increase was similar to the response in intact mirex-dosed rats with a maximum 80% increase at 72 h postmirex dose.

Environmental Cognition in a Coastal Fishing Village Area and its Internal Structure

2020 ◽  
Vol 103 ◽  
pp. 19-25
Author(s):  
Tetsumasa Sunada ◽  
Hirotomo Ohuchi ◽  
Shichun Zong ◽  
Toshihiro Kimura
Keyword(s):  
Physical Environment ◽  
Visual Recognition ◽  
Visible Region ◽  
3 Dimensional ◽  
Fishing Villages ◽  
Environmental Cognition ◽  
Implicate Order ◽  
Local Residents ◽  
Relationship Of ◽  
The Relationship

This study considered the relationship between the extent of the Environmental cognition by residents in the coastal fishing area and the physical environment, as ascertained from a questionnaire survey of local residents. The Object is 59 coastal fishing villages (Izu and Bousou peninsula in Japan) in which the sea, a town, and a mountain are realized in one, and has a complicated geographical feature. We have been researched the complexity and metamorphosis patterns of common areas in coastal fishing regions using area drawing method. As a result, villages were classified into five typology of villages based on the relationship between physical environment and landscape recognition. Further, this study analysis Explicate Order and Implicate Order formed from the mutual relationship of the cognitive area and visibility/Invisibility and the clarify characteristic between cognitive area and visibility. We analysis visibility with visible region image using the 3-dimensional shade picture which applied the inverse-square damping which is an approximation to man's visual recognition and which is obtained from a spread of light. From the above analysis, correlativity of cognitive area and visibility by landscape cognition of residents was shown and its Composition was revealed.

Multivariate analysis of the relationship of six variables to blood pressure: Findings from Chicago Community Surveys, 1965–1971

1975 ◽  
Vol 28 (10) ◽  
pp. 499-525 ◽  
Author(s):  
Jeremiah Stamler ◽  
Rose Stamler ◽  
Peter Rhomberg ◽  
Alan Dyer ◽  
David M. Berkson ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Multivariate Analysis ◽  
Community Surveys ◽  
Relationship Of ◽  
The Relationship
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