3 Background: Financial hardship from cancer is often attributed to high costs of care, but the relationship of out-of-pocket (OOP) medical burden to racial disparities seen in financially distressed cancer patients is underexplored. Using the Health and Retirement Study, a national longitudinal survey of U.S. households from 1992-2012, we examined the effect of a cancer diagnosis on financial hardship and OOP medical spending among black and white adults age-eligible for Medicare insurance. Methods: Analyses were restricted to adults 65 years or older to reduce heterogeneity in employment and insurance. Financial hardship was defined as new financial insolvency, > 50% decline in net worth, acquisition of debt, or high medical burden (OOP medical spending > 20% of income). The proportions of black and white cancer patients reporting financial hardship, as well as OOP medical spending, household debt, income, net worth, and insurance status by racial group were determined. Statistical comparisons using a t-test for proportions or Wilcoxon rank-sum testing were performed. Results: A total of 2158 white and 322 black cancer patients were identified. Black cancer patients were more likely than white cancer patients to report new financial insolvency (6.8% vs 1.6%; p < 0.0001), loss of > 50% of net worth (26.7% vs 15.3%; p < 0.0001), or new debt (27.6% vs 14.9%); p < 0.0001). OOP medical spending, median household income, and net worth were significantly lower in black vs white cancer patients. The rate of high medical burden was similar between black vs white patients (22.1% vs 21.6%, respectively). Dual Medicare/Medicaid enrollment was higher among black vs white cancer patients, at 23.1% and 7.4%. Conclusions: Significant racial disparities in the prevalence of financial hardship were seen among older adult cancer patients, despite lower OOP medical spending and increased dual Medicare/Medicaid enrollment by black vs white cancer patients. Interventions aimed at alleviating disparities in financial outcome among cancer patients should account for pre-existing differences in socioeconomic status in addition to direct medical costs.