Determination of Chemical Oxygen Demand in Domestic Wastewater by near Infrared Spectrometry of Seston and Partial Least Squares Calibration

NIR news ◽  
2008 ◽  
Vol 19 (1) ◽  
pp. 8-9 ◽  
Author(s):  
Antonio C. Sousa ◽  
Maria Monica L.M. Lucio ◽  
Ovídeo F. Bezerra Neto ◽  
Glauciene P.S. Marcone ◽  
Alessandra F.C. Pereira ◽  
...  
Keyword(s):  
Chemical Oxygen Demand ◽  
Least Squares ◽  
Partial Least Squares ◽  
Near Infrared ◽  
Oxygen Demand ◽  
Domestic Wastewater ◽  
Infrared Spectrometry ◽  
Near Infrared Spectrometry

scholarly journals Determination of Propranolol Hydrochloride in Pharmaceutical Preparations Using Near Infrared Spectrometry with Fiber Optic Probe and Multivariate Calibration Methods

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Jucelino Medeiros Marques Junior ◽  
Aline Lima Hermes Muller ◽  
Edson Luiz Foletto ◽  
Adilson Ben da Costa ◽  
Cezar Augusto Bizzi ◽  
...  
Keyword(s):  
Least Squares ◽  
Near Infrared ◽  
Fiber Optic ◽  
Pharmaceutical Preparations ◽  
Infrared Spectrometry ◽  
Propranolol Hydrochloride ◽  
Fiber Optic Probe ◽  
Near Infrared Spectrometry ◽  
Optic Probe

A method for determination of propranolol hydrochloride in pharmaceutical preparation using near infrared spectrometry with fiber optic probe (FTNIR/PROBE) and combined with chemometric methods was developed. Calibration models were developed using two variable selection models: interval partial least squares (iPLS) and synergy interval partial least squares (siPLS). The treatments based on the mean centered data and multiplicative scatter correction (MSC) were selected for models construction. A root mean square error of prediction (RMSEP) of 8.2 mg g−1was achieved using siPLS (s2i20PLS) algorithm with spectra divided into 20 intervals and combination of 2 intervals (8501 to 8801 and 5201 to 5501 cm−1). Results obtained by the proposed method were compared with those using the pharmacopoeia reference method and significant difference was not observed. Therefore, proposed method allowed a fast, precise, and accurate determination of propranolol hydrochloride in pharmaceutical preparations. Furthermore, it is possible to carry out on-line analysis of this active principle in pharmaceutical formulations with use of fiber optic probe.

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